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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BM804118 is the fusion of parental proteins PDCD2L, CENPV (from a repository: Thu Dec 5 17:35:35 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins3 (21.43 %)
The number (and %) of the tumor suppressors5 (35.71 %)
Total number of binary PPIs (saturation %)39 (42.86 %)
The number (and %) of affected PPIs13 (33.33 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI5.000
Assortativity coefficient-0.3618
The network average Clustering coefficient0.670
The number (and %) of a zero Clustering coefficients2 (14.29 %)
The number (and %) of a zero Betweenness Centrality7 (50.00 %)


List of the fusions

PPI for parental proteins: PDCD2L,PIGL All fusions
: BM804118;
Proteins found in more fusions EZH2 (see 1 fusions); LYN (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BM804118chimera130.28283.300Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
GFA (PF04828, IPR006913): Glutathione-dependent formaldehyde-activating enzyme
2 EEDsuppressor70.7332.400WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
3 EZH2suppressor41.0000CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
4 HIST1H2BGoncoprotein100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
5 HNRNPUinteractor80.6436.300CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
6 IFI16suppressor31.0000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
7 ILF2interactor70.7143.800DZF (PF07528, IPR006561, SM00572): DZF domain
8 LYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9 NOP56interactor60.8001.567Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
10 NPM1suppressor51.0000Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
11 PHKG2interactor100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
12 RPL10suppressor80.53610.233Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
13 SORT1interactor21.0000Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3,
14 SYNCRIPinteractor60.6674.400RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CENPVparental proteinMito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
GFA (PF04828, IPR006913): Glutathione-dependent formaldehyde-activating enzyme
2 CEP120interactorC2 (PF00168, IPR000008, SM00239): C2 domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
DUF3668 (PF12416, IPR022136): Cep120 protein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
3 CNTROBinteractorDUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
4 COPS6interactorDUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
5 ITGB1BP2interactorCHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
6 NAP1L5interactorNAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
SspB (PF04386, IPR007481): Stringent starvation protein B
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
7 PCBP3interactorKH_1 (PF00013, IPR004088, SM00322): KH domain
8 PDCD2Lparental proteinPDCD2_C (PF04194, IPR007320): Programmed cell death protein 2, C-terminal putative domain
zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
9 PRMT3interactorPrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
10 RPS2interactorRibosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
11 SLX4IPinteractorUPF0492 (PF15744, IPR031479): Uncharacterized protein family UPF0492
12 SRP14interactorSRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
13 XPO1interactorCRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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