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Powered by Cytoscape Web for: BM048392 is the fusion of parental proteins NPTN, KRT19 (from a repository: Thu Dec 8 08:33:11 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins17 (31.48 %)
The number (and %) of the tumor suppressors7 (12.96 %)
Total number of binary PPIs (saturation %)194 (13.56 %)
The number (and %) of affected PPIs53 (27.32 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI6.259
Assortativity coefficient-0.3632
The network average Clustering coefficient0.580
The number (and %) of a zero Clustering coefficients4 (7.41 %)
The number (and %) of a zero Betweenness Centrality15 (27.78 %)


List of the fusions

PPI for parental proteins: NPTN,KRT19 All fusions
: BM048392;
Proteins found in more fusions KDM1A (see 2 fusions); AMOTL2 (see 1 fusions); FANCG (see 1 fusions); LGALS3 (see 2 fusions); GRB2 (see 1 fusions); BAG3 (see 4 fusions); CEP57L1 (see 1 fusions); APC (see 1 fusions); PLEKHA5 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BM048392chimera530.0842102.324C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
Filament (PF00038, IPR001664): Intermediate filament protein
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
2 ABI2suppressor60.7001.300Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3 AMOTL2protein found in more fusions50.6671.333HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
4 APCsuppressor41.0000APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
5 BAG3oncoprotein60.7001.619BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 C10orf10interactor31.0000DEPP (PF15343, IPR020133): Decidual protein induced by progesterone family
7 C1orf109interactor40.5002.167CK2S (PF15011, IPR029159): Casein Kinase 2 substrate
8 CARD9interactor70.4008.333CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
9 CCDC146interactor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
10 CEP57L1protein found in more fusions80.4767.867Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
XhlA (PF10779, IPR019715): Haemolysin XhlA
YqzE (PF14038, IPR025622): YqzE-like protein
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
11 CRKoncoprotein60.6004.167SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12 DGCR6Linteractor21.0000DGCR6 (PF07324, IPR010849): DiGeorge syndrome critical region 6 (DGCR6) protein
13 EEDsuppressor80.4768.686WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
14 EIF4A3interactor130.33334.486DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15 EIF4E2interactor50.5004.333IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
16 EIF4ENIF1interactor21.0000EIF4E-T (PF10477, IPR018862): Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
17 ESR1suppressor60.6003.067Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
18 EXOC8interactor70.5715.567K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Vps51 (PF08700): Vps51/Vps67
Syntaxin_2 (PF14523): Syntaxin-like protein
Exo84_C (PF16528, IPR032403): Exocyst component 84 C-terminal
19 FAM107Ainteractor31.0000DUF1151 (PF06625, IPR009533): Protein of unknown function (DUF1151)
20 FAM124Binteractor30.6670.667FAM124 (PF15067, IPR029380): FAM124 family
21 FANCGsuppressor31.0000BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
22 FBXO6interactor40.8330.286FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
23 FN1oncoprotein90.52811.857fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
24 GRB2oncoprotein120.38226.352SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
25 HAUS1interactor100.38916.800THP2 (PF09432, IPR018557): Tho complex subunit THP2
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
26 HGSinteractor90.41715.333FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
27 IKZF3suppressor70.3338.167C1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
28 ITGA4interactor90.6793.538FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
29 KDM1Aprotein found in more fusions90.39313.900Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
30 KIFC3oncoprotein90.46410.900Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
31 KRT15interactor180.222106.100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
32 KRT2interactor100.37821.805Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
33 KRT6Binteractor70.4768.233Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
34 LGALS3oncoprotein41.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
35 MCM5oncoprotein80.5366.519MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
36 PAN2interactor30.6671.000RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
37 PCM1oncoprotein70.5247.233FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
AAA_23 (PF13476): AAA domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
38 PLEKHA5protein found in more fusions200PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
39 PNNsuppressor21.0000Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
40 POLR1Cinteractor30.6670.667RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
41 POU5F1oncoprotein31.0000Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
42 PPP1R18interactor30.6670.667Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
43 SFI1interactor200HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
IncA (PF04156, IPR007285): IncA protein
44 SLC25A5interactor110.45520.805Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
45 SURF2interactor100SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
46 TBC1D7interactor100RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
47 TFPToncoprotein40.6670.667GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
48 UBE2Iinteractor70.4008.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
49 UBXN1interactor40.6671.000Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
50 UCHL5oncoprotein50.6671.667Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
51 USHBP1interactor130.25843.900DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
52 USP32oncoprotein21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
53 VCAM1interactor60.7331.190C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
54 ZNF638interactor30.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-met (PF12874): Zinc-finger of C2H2 type
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 KRT19parental proteinFilament (PF00038, IPR001664): Intermediate filament protein
2 MAGOHinteractorMago_nashi (PF02792, IPR004023): Mago nashi protein
3 NDUFV2interactor2Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
4 NIT2suppressorCN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
5 NPTNparental proteinC2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
6 VMA21interactorVMA21 (PF09446, IPR019013): VMA21-like domain

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