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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BI860302 is the fusion of parental proteins NFKBIB, EEF1D (from a repository: Tue Dec 13 17:16:19 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)121
The number (and %) of the onco-proteins45 (37.19 %)
The number (and %) of the tumor suppressors18 (14.88 %)
Total number of binary PPIs (saturation %)908 (12.51 %)
The number (and %) of affected PPIs120 (13.22 %)
The number of possible different fusions30
PPI diameter2
PPI radius1
The average degree of PPI14.083
Assortativity coefficient-0.2158
The network average Clustering coefficient0.495
The number (and %) of a zero Clustering coefficients3 (2.48 %)
The number (and %) of a zero Betweenness Centrality14 (11.57 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: NFKBIB,EEF1D All fusions
: BI860302;
Proteins found in more fusions APP (see 4 fusions); LMNA (see 3 fusions); EEF1G (see 1 fusions); STAU1 (see 2 fusions); ELF3 (see 2 fusions); EEF1A1 (see 1 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); PPME1 (see 1 fusions); HUWE1 (see 2 fusions); CUL1 (see 3 fusions); AHNAK (see 2 fusions); SQSTM1 (see 5 fusions); GRB2 (see 1 fusions); SIAH1 (see 4 fusions); NFKB1 (see 2 fusions); BAG3 (see 4 fusions); MCM2 (see 1 fusions); APC (see 1 fusions); HSPB1 (see 4 fusions); FOS (see 4 fusions); RXRA (see 2 fusions); CSNK2A1 (see 1 fusions); SIAH2 (see 1 fusions); IKBKB (see 2 fusions); HCFC1 (see 2 fusions); NTRK1/TPR (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BI860302chimera1200.1038008.640EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
2 ABTB1interactor21.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
3 ACLYinteractor130.47411.074ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain
CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding
4 ADRB2interactor110.5567.6677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 AHNAKsuppressor150.45121.666DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945)
ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein
DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993)
DUF4097 (PF13349, IPR025164): Putative adhesin
Ntox37 (PF15535, IPR029108): Bacterial toxin 37
6 AKAP8interactor80.4647.065AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95)
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
7 ANLNoncoprotein50.7002.067Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
8 APCsuppressor100.33317.233APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
9 APPprotein found in more fusions280.208174.738APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10 ARHGAP21interactor60.6673.500PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
MAJIN (PF15077, IPR027816): Membrane-anchored junction protein
PH_9 (PF15410): Pleckstrin homology domain
11 ASCC2interactor31.0000CUE (PF02845, IPR003892, SM00546): CUE domain
BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
12 ATG7interactor50.6001.034ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
13 BAG3oncoprotein160.24852.600BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
14 BAG6interactor70.4003.581DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
15 BTRConcoprotein220.27696.734WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
16 CAMSAP2interactor31.0000Bundlin (PF05307, IPR007971): Bundlin
IncA (PF04156, IPR007285): IncA protein
Presenilin (PF01080, IPR001108): Presenilin
CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
FAM60A (PF15396, IPR026065): Protein Family FAM60A
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
17 CCT2interactor190.43925.776Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 CCT6Ainteractor170.39724.207Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19 CD48interactor21.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
20 CD81interactor110.6673.979Tetraspannin (PF00335, IPR018499): Tetraspanin family
21 CDC25Aoncoprotein80.5003.752M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
22 CDK2suppressor300.261140.736Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
23 CRMP1interactor60.8001.333Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
24 CSNK2A1oncoprotein230.35180.853Pkinase (PF00069, IPR000719): Protein kinase domain
25 CUL1suppressor290.357110.957Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
26 CUL2suppressor170.50021.149Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 CUL5suppressor180.48434.489Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
28 CUL7protein found in more fusions320.256123.711ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
29 DDX46interactor70.6673.036CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
CdAMP_rec (PF06153, IPR010375): Cyclic-di-AMP receptor
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FAM176 (PF14851): FAM176 family
30 DNAJA3suppressor80.3939.553DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
31 ECH1interactor60.6002.187ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
32 EEDsuppressor210.31149.265WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
33 EEF1A1suppressor330.387135.260GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
34 EEF1A2oncoprotein130.43619.571GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
35 EEF1B2interactor300.35795.488EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
36 EEF1Gprotein found in more fusions290.307137.923EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
37 ELF3oncoprotein51.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
38 EPRSinteractor180.30142.294GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
39 ERP27interactor100Thioredoxin_6 (PF13848): Thioredoxin-like domain
40 FBXO6interactor190.38627.203FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
41 FBXW11interactor220.210110.747WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
42 FLNCinteractor110.45513.603CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
43 FN1oncoprotein320.280118.171fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
44 FOSoncoprotein100.5009.350bZIP_1 (PF00170, IPR004827): bZIP transcription factor
45 FOSL2oncoprotein50.5003.619bZIP_1 (PF00170, IPR004827): bZIP transcription factor
46 FOXB1interactor40.6670.800Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
47 FOXG1oncoprotein50.6002.667SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
48 FOXI2interactor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
49 FOXK1interactor60.6673.000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
50 FOXL1oncoprotein21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
51 FRA10AC1interactor21.0000SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
Fra10Ac1 (PF09725, IPR019129): Folate-sensitive fragile site protein Fra10Ac1
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
52 GARSinteractor80.5362.586HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
53 GLI1suppressor40.6670.667zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
54 GRB2oncoprotein170.45029.673SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
55 GTF2F1interactor80.5714.827TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
56 HCFC1protein found in more fusions90.4647.998fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
57 HECW2interactor60.6003.067C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
58 HEXDCinteractor100Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
59 HNRNPKoncoprotein330.333117.542ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
60 HSPB1oncoprotein250.35983.370HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
61 HUWE1oncoprotein280.302121.766BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
62 IGSF8oncoprotein120.5159.197V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
63 IKBKBprotein found in more fusions110.44414.188FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
64 ITGA4interactor260.42747.629FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
65 JUNoncoprotein110.46716.050bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
66 KTN1oncoprotein60.6672.952ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
67 LIMA1suppressor100.40016.810LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
68 LMNAprotein found in more fusions210.31175.183Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
69 MAP1Binteractor80.3216.285DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
Striatin (PF08232, IPR013258): Striatin family
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
70 MATR3interactor160.48616.490DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
71 MAXsuppressor60.6001.700ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
72 MCCsuppressor30.6670.333ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
FAM76 (PF16046, IPR032017): FAM76 protein
73 MCCC1interactor50.7001.095Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
74 MCM2oncoprotein380.351182.149AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
75 NCOR2oncoprotein90.5838.833CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
76 NFKB1suppressor160.41039.588Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
77 NFKB2oncoprotein90.8930.700Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Death (PF00531, IPR000488, SM00005): Death domain
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
78 NFKBIAoncoprotein130.53817.484Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
79 NPM1suppressor400.344206.897Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
80 NTRK1oncoprotein580.186785.857I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
81 OARD1interactor30.6670.6673HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Macro (PF01661, IPR002589, SM00506): Macro domain
82 PCBP1oncoprotein240.42853.189Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
83 PKMoncoprotein280.38199.879PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
84 PKN2interactor90.3939.272C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
85 POT1interactor80.4766.752POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
86 PPME1protein found in more fusions60.6001.767Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
87 PSMD10interactor70.3819.686Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
88 RAD21oncoprotein90.5287.968Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
89 RAD52oncoprotein41.0000Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
90 RELoncoprotein100.53312.983RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
91 RELAoncoprotein240.292115.717DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
92 RNF2interactor220.21496.989zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
93 RPL15interactor150.6387.286Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
94 RPL18interactor210.48122.016Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
95 RTN4suppressor90.46411.036CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
96 RXRAoncoprotein51.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
97 SF3A3interactor150.32435.002DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449)
SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
98 SIAH1suppressor70.4674.371Sina (PF03145, IPR018121): Seven in absentia protein family
99 SIAH2oncoprotein50.6671.500Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
100 SLC33A1interactor30.6670.500Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
101 SMURF1interactor130.36411.828C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
102 SQSTM1oncoprotein150.38532.550PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
103 SRRM2interactor160.45817.224cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
104 SRRTinteractor120.50012.322ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546)
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
105 STAU1protein found in more fusions240.44734.903dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
106 STMN1interactor100.42210.018Stathmin (PF00836, IPR000956): Stathmin family
107 SUPT5Hinteractor100.4896.237KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
108 SYNPOinteractor70.5247.500Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
109 TERF1interactor140.33327.943TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
110 TINF2interactor80.4767.419TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
111 TPRoncoprotein140.52715.161Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373)
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
112 TPT1interactor50.5001.256TCTP (PF00838, IPR018105): Translationally controlled tumour protein
113 TSPAN1oncoprotein100Tetraspannin (PF00335, IPR018499): Tetraspanin family
114 U2AF2protein found in more fusions250.46043.489RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
115 VARSinteractor220.260118.545Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
116 VCAM1interactor220.38537.766C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
117 VIMsuppressor230.34259.393Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
118 VPS52interactor41.0000Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
119 XPO1interactor340.230283.898CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
120 ZBTB7Ainteractor60.7002.000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
GAGA (PF09237, IPR015318): GAGA factor
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
121 ZW10interactor70.4296.771Zw10 (PF06248, IPR009361): Centromere/kinetochore Zw10
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BAK1oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
2 BIRC7interactorBIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
3 BRAPinteractorBRAP2 (PF07576, IPR011422): BRCA1-associated protein 2
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
4 CHUKsuppressorPkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
5 EEF1Dparental proteinEF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
6 ESR2suppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
7 FHL3interactorLIM (PF00412, IPR001781, SM00132): LIM domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
8 GIT2interactorArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Sen15 (PF09631, IPR018593): Sen15 protein
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
9 HIF1ANinteractorCupin_8 (PF13621): Cupin-like domain
10 IKBKGinteractorCENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
11 NFKBIBparental proteinAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
12 NKIRAS1interactorRas (PF00071, IPR001806, SM00173): Ras family
13 POLR1EinteractorRNA_pol_I_A49 (PF06870, IPR009668): A49-like RNA polymerase I associated factor
14 PPARGsuppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
15 TBPinteractorTBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
16 TRE17interactorNA

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