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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BI495640 is the fusion of parental proteins FOXO1 (from a repository: Fri Dec 23 00:38:52 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins20 (37.74 %)
The number (and %) of the tumor suppressors21 (39.62 %)
Total number of binary PPIs (saturation %)265 (19.23 %)
The number (and %) of affected PPIs52 (19.62 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI9.057
Assortativity coefficient-0.4058
The network average Clustering coefficient0.551
The number (and %) of a zero Clustering coefficients7 (13.21 %)
The number (and %) of a zero Betweenness Centrality15 (28.30 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: FOXO1 All fusions
: BI495640;
Proteins found in more fusions CREBBP (see 6 fusions); RARA/PML (see 21 fusions); SMAD4 (see 2 fusions); YWHAG (see 1 fusions); SETD7 (see 2 fusions); RARA (see 4 fusions); YWHAZ (see 1 fusions); STUB1 (see 1 fusions); GSK3B (see 1 fusions); NLK (see 4 fusions); PARP1 (see 1 fusions); EP300 (see 1 fusions); NCOA1 (see 2 fusions); PML (see 4 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BI495640chimera520.1421565.937K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
2 AKT1oncoprotein200.45045.721PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 ARoncoprotein200.45638.106Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
4 ATG7interactor31.0000ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
5 CCNB1oncoprotein70.6672.519Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
6 CDKN1Asuppressor140.50522.945CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
7 CEBPBoncoprotein110.6894.129RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
8 CREBBPsuppressor230.40376.611Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
9 CUX1suppressor40.5001.100Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein
CUT (PF02376, IPR003350, SM01109): CUT domain
DegS (PF05384, IPR008595): Sensor protein DegS
DivIC (PF04977, IPR007060): Septum formation initiator
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Swi5 (PF07061, IPR010760): Swi5
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
ApoO (PF09769, IPR019166): Apolipoprotein O
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
10 DLX5interactor200Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DLL_N (PF12413, IPR022135): Homeobox protein distal-less-like N terminal
11 DNAJC9oncoprotein100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
12 EP300oncoprotein240.37989.319Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
13 ESR1suppressor210.40548.834Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
14 FHL2oncoprotein90.8570.636LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
15 FOXO4suppressor110.54514.348Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
16 FOXO6suppressor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
17 FSHRinteractor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
GnHR_trans (PF12369, IPR024635): Gonadotropin hormone receptor transmembrane region
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
18 GSK3Bsuppressor90.6073.843Pkinase (PF00069, IPR000719): Protein kinase domain
19 HNF4Asuppressor100.6114.181zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
20 HOXA11oncoprotein100DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3528 (PF12045, IPR021918): Protein of unknown function (DUF3528)
21 HOXA5interactor100Chorion_2 (PF03964, IPR005649): Chorion family 2
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Terminase_5 (PF06056, IPR010332): Putative ATPase subunit of terminase (gpP-like)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
22 HOXD13oncoprotein21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
HoxA13_N (PF12284, IPR022067): Hox protein A13 N terminal
23 IRF3suppressor80.6671.994IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
24 LRPPRCinteractor30.6670.250DED (PF01335, IPR001875, SM00031): Death effector domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
PPR (PF01535, IPR002885): PPR repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
TPR_19 (PF14559): Tetratricopeptide repeat
PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
25 MDM2oncoprotein220.33381.804Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
26 MORF4L2interactor21.0000MRG (PF05712, IPR026541): MRG
27 MST1suppressor100Kringle (PF00051, IPR000001): Kringle domain
PAN_1 (PF00024, IPR003014): PAN domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
28 NCOA1oncoprotein110.6445.413DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
29 NLKprotein found in more fusions70.7331.082Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
30 PARP1suppressor80.8101.033BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
31 PIK3R3interactor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
32 PMLsuppressor100.5566.444zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
33 RARAoncoprotein100.6673.725zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
34 RB1suppressor150.35246.095RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
35 RECQLoncoprotein21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Lipoprotein_3 (PF00938, IPR001595): Lipoprotein
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
36 RFWD2suppressor40.6670.333Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
37 SATB1oncoprotein50.6001.917CUT (PF02376, IPR003350, SM01109): CUT domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB
CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
38 SATB2interactor100CUT (PF02376, IPR003350, SM01109): CUT domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB
CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
39 SETD7protein found in more fusions70.8000.648MORN (PF02493, IPR003409, SM00698): MORN repeat
MORN_2 (PF07661, IPR011652): MORN repeat variant
SET (PF00856, IPR001214, SM00317): SET domain
40 SIRT1suppressor190.28868.433DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
41 SIRT2suppressor40.6670.583SIR2 (PF02146, IPR003000): Sir2 family
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
42 SKP2suppressor110.6009.371LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
43 SMAD3oncoprotein190.48431.220MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
44 SMAD4suppressor170.50023.544MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
45 SMARCA4suppressor110.6556.500DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
46 SNX17interactor21.0000FERM_M (PF00373, IPR019748): FERM central domain
PX (PF00787, IPR001683, SM00312): PX domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
47 STUB1suppressor80.8570.550U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
48 TNS2interactor100PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
PRIMA1 (PF16101): Proline-rich membrane anchor 1
49 TSC2suppressor80.6074.425Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
Tuberin (PF03542, IPR018515): Tuberin
DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
50 XPO1interactor130.26936.772CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
51 YWHAGprotein found in more fusions60.7000.87214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
52 YWHAQinteractor100.40016.68914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
53 YWHAZprotein found in more fusions90.4648.07514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 FOXO1parental proteinK_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
2 FOXO3BinteractorNA

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