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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BI491020 is the fusion of parental proteins MCL1 (from a repository: Sun Dec 18 06:23:53 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins15 (36.59 %)
The number (and %) of the tumor suppressors10 (24.39 %)
Total number of binary PPIs (saturation %)137 (16.71 %)
The number (and %) of affected PPIs40 (29.20 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI5.659
Assortativity coefficient-0.3079
The network average Clustering coefficient0.527
The number (and %) of a zero Clustering coefficients7 (17.07 %)
The number (and %) of a zero Betweenness Centrality15 (36.59 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MCL1 All fusions
: BI491020;
Proteins found in more fusions TRAF6 (see 1 fusions); HUWE1 (see 2 fusions); PCNA (see 1 fusions); BAG3 (see 4 fusions); BCL2L1 (see 1 fusions); PINK1 (see 3 fusions); LYN (see 2 fusions); MYC (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BI491020chimera400.0971156.533Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
2 AGO2interactor31.0000ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
3 BADoncoprotein21.0000Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
4 BAG3oncoprotein90.46411.167BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 BAG4interactor40.8330.500BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
6 BBC3suppressor21.0000PUMA (PF15826, IPR031661): Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
7 BCL2L1oncoprotein120.23637.400Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
8 BCL2L11suppressor50.5002.733Bclx_interact (PF08945, IPR015040): Bcl-x interacting, BH3 domain
Bim_N (PF06773, IPR014771): Bim protein N-terminus
9 BECN1suppressor70.4675.567APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
10 BIDoncoprotein60.6002.833BID (PF06393, IPR010479): BH3 interacting domain (BID)
11 BTRConcoprotein80.38110.167WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
12 CASP3interactor60.5003.500Peptidase_C14 (PF00656, IPR011600): Caspase domain
13 DAD1interactor100DAD (PF02109, IPR003038): DAD family
14 ECM1oncoprotein100ECM1 (PF05782, IPR008605): Extracellular matrix protein 1 (ECM1)
15 FBXW7suppressor60.5004.000Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
16 FLGinteractor100Filaggrin (PF03516, IPR003303): Filaggrin
S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
Hid1 (PF12722): High-temperature-induced dauer-formation protein
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266)
DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1
17 HSPA1Ainteractor80.4649.733HSP70 (PF00012, IPR013126): Hsp70 protein
18 HSPA4interactor130.29546.167Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
19 HSPA8oncoprotein70.6194.500HSP70 (PF00012, IPR013126): Hsp70 protein
20 HUWE1oncoprotein90.42913.833BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
21 LYNoncoprotein41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
22 MAPK10suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
23 MYConcoprotein80.5247.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
24 NXF1interactor80.4299.167NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
25 PARK2suppressor100.41714.700IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
26 PCNAoncoprotein60.6002.333PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
27 PIN1suppressor40.8330.667Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
28 PINK1protein found in more fusions70.6002.967Pkinase (PF00069, IPR000719): Protein kinase domain
29 PMAIP1interactor30.6670.667PMAIP1 (PF15150, IPR024140): Phorbol-12-myristate-13-acetate-induced
30 PRKAA1suppressor40.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
31 PRKAB1oncoprotein31.0000AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
32 PRKAB2interactor41.0000AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
33 SERPINB7interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
34 STARD9interactor100START (PF01852, IPR002913, SM00234): START domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
35 TNKSinteractor200Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
36 TP53suppressor150.27556.300DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
37 TRAF6protein found in more fusions50.6671.067SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
38 TRIM11interactor200ATP-synt_B (PF00430, IPR002146): ATP synthase B/B' CF(0)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
39 UHRF2suppressor60.7001.833PHD (PF00628, IPR019787, SM00249): PHD-finger
SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
40 UNKinteractor40.8330.667MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
41 USP9Xinteractor31.0000DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ASPRV1interactorgag-asp_proteas (PF13975): gag-polyprotein putative aspartyl protease
2 ATG12interactorAPG12 (PF04110, IPR007242): Ubiquitin-like autophagy protein Apg12
3 BAK1oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
4 BAXsuppressorBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
5 BIKsuppressorbcl-2I13 (PF12201, IPR024579): Bcl2-interacting killer, BH3-domain containing
6 BMFsuppressorBMF (PF15185, IPR028192): Bcl-2-modifying factor, apoptosis
7 BOKoncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
8 CAV1suppressorCaveolin (PF01146, IPR001612): Caveolin
9 CPT2interactorCarn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
10 EDNRAinteractor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
11 HRKinteractorHarakiri (PF15196, IPR017249): Activator of apoptosis harakiri
12 MCL1parental proteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
13 PRKAG1interactorCBS (PF00571, IPR000644, SM00116): CBS domain
14 TPT1interactorTCTP (PF00838, IPR018105): Translationally controlled tumour protein
15 VDAC1interactorPorin_3 (PF01459, IPR027246): Eukaryotic porin

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