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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BI022207 is the fusion of parental proteins ZNRF1 (from a repository: Tue Jan 10 04:28:45 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins7 (50.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)37 (40.66 %)
The number (and %) of affected PPIs13 (35.14 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.714
Assortativity coefficient-0.2484
The network average Clustering coefficient0.583
The number (and %) of a zero Clustering coefficients4 (28.57 %)
The number (and %) of a zero Betweenness Centrality10 (71.43 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ZNRF1 All fusions
: BI022207;
Proteins found in more fusions UBE2E1 (see 2 fusions); UBE2D2 (see 2 fusions); UBC (see 1 fusions); UBE2E2 (see 1 fusions); UBE2N (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BI022207chimera130.167106.000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
2 CDC34oncoprotein31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
3 UBCprotein found in more fusions100.36122.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
4 UBE2D1interactor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
5 UBE2D2oncoprotein50.8330.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
6 UBE2D3interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
7 UBE2D4interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
8 UBE2E1protein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
9 UBE2E2protein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
10 UBE2E3interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
11 UBE2Nprotein found in more fusions51.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
12 UBE2V1interactor50.8001.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
13 UBE2V2interactor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
14 UBE2Winteractor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AARS2oncoproteintRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
2 ATP1A1interactorCation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
3 ATP1A2interactorCation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Sigma70_r4 (PF04545, IPR007630): Sigma-70, region 4
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
4 BHMTinteractorS-methyl_trans (PF02574, IPR003726): Homocysteine S-methyltransferase
5 FBXW5interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
6 GLULinteractorGln-synt_C (PF00120, IPR008146): Glutamine synthetase, catalytic domain
Gln-synt_N (PF03951, IPR008147): Glutamine synthetase, beta-Grasp domain
7 NCEH1interactorAbhydrolase_3 (PF07859, IPR013094): alpha/beta hydrolase fold
8 NMT1oncoproteinNMT (PF01233, IPR022676): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
NMT_C (PF02799, IPR022677): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
9 NMT2interactorNMT (PF01233, IPR022676): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
NMT_C (PF02799, IPR022677): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
10 TSEN2interactortRNA_int_endo (PF01974, IPR006677): tRNA intron endonuclease, catalytic C-terminal domain
tRNA_int_endo_N (PF02778, IPR006678): tRNA intron endonuclease, N-terminal domain
SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
11 TSEN54interactortRNA_int_endo_N (PF02778, IPR006678): tRNA intron endonuclease, N-terminal domain
tRNA_int_end_N2 (PF12928, IPR024336): tRNA-splicing endonuclease subunit sen54 N-term
12 YWHAQinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
13 ZNRF1parental proteinzf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
RNF220 (PF15926, IPR031824): E3 ubiquitin-protein ligase RNF220
14 ZNRF2interactorzf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
RNF220 (PF15926, IPR031824): E3 ubiquitin-protein ligase RNF220

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