Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BI012638 is the fusion of parental proteins OS9 (from a repository: Sat Nov 12 09:31:44 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)47
The number (and %) of the onco-proteins14 (29.79 %)
The number (and %) of the tumor suppressors6 (12.77 %)
Total number of binary PPIs (saturation %)133 (12.30 %)
The number (and %) of affected PPIs46 (34.59 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI5.064
Assortativity coefficient-0.4866
The network average Clustering coefficient0.588
The number (and %) of a zero Clustering coefficients12 (25.53 %)
The number (and %) of a zero Betweenness Centrality30 (63.83 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: OS9 All fusions
: BI012638;
Proteins found in more fusions PLOD2 (see 1 fusions); VCP (see 4 fusions); EGLN1 (see 1 fusions); EGFR (see 2 fusions); SREBF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BI012638chimera460.0711719.205DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
2 ACVR1Boncoprotein21.0000Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3 AMFRoncoprotein100.6396.719CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 ASGR2interactor21.0000UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
5 AUP1interactor50.9000.286CUE (PF02845, IPR003892, SM00546): CUE domain
6 BSGinteractor30.6670.286Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
7 CALR3interactor100Calreticulin (PF00262, IPR001580): Calreticulin family
8 CERCAMinteractor21.0000Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
9 COLGALT1interactor31.0000Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
10 CREB3interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
11 DCSTAMPinteractor100DC_STAMP (PF07782, IPR012858): DC-STAMP-like protein
PrgI (PF12666, IPR024414): PrgI family protein
12 DNAJB11interactor60.7331.686DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
13 EGFRoncoprotein110.46718.633Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 EGLN1suppressor41.0000zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
15 EGLN3suppressor41.00002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
16 ERLEC1interactor60.6674.200PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
17 FAF2interactor110.57811.452DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
18 FBXO15interactor100F-box-like (PF12937, IPR001810): F-box-like
F-box_4 (PF15966, IPR001810): F-box
19 FOXM1oncoprotein100EspF (PF04806, IPR006891): EspF protein repeat
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
20 FUT9interactor100Glyco_transf_10 (PF00852, IPR001503): Glycosyltransferase family 10 (fucosyltransferase) C-term
Glyco_tran_10_N (PF17039, IPR031481): Fucosyltransferase, N-terminal
21 GABRA1interactor31.0000Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
22 GGHoncoprotein31.0000Peptidase_C26 (PF07722, IPR011697): Peptidase C26
23 HIF1Asuppressor60.4678.000Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
24 HSP90B1suppressor110.58212.871CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
25 HSPA5oncoprotein150.40736.319HSP70 (PF00012, IPR013126): Hsp70 protein
26 HYOU1interactor60.8000.986HSP70 (PF00012, IPR013126): Hsp70 protein
AbiEi_3_N (PF17194): Transcriptional regulator, AbiEi antitoxin N-terminal domain
27 LONP2interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
Phage_CP76 (PF06892, IPR009679): Phage regulatory protein CII (CP76)
Sld5 (PF05916, IPR021151): GINS complex protein
TIP49 (PF06068, IPR010339): TIP49 C-terminus
28 MYH9suppressor40.8330.200IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
29 NAAAinteractor100CBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family
NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
30 NUP210interactor21.0000Big_2 (PF02368, IPR003343, SM00635): Bacterial Ig-like domain (group 2)
31 PLOD2protein found in more fusions41.00002OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily
Anp1 (PF03452, IPR005109): Anp1
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
32 PPIBinteractor41.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
33 RBX1oncoprotein31.0000zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
34 RPN1oncoprotein80.6794.005Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
35 SARAFinteractor41.0000SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
36 SEL1Loncoprotein130.38532.186fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
37 SMAD2suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
38 SMPD1interactor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
39 SNRPD2interactor21.0000LSM (PF01423, IPR001163): LSM domain
40 SREBF2protein found in more fusions31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
41 TCTN1interactor130.34644.033DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
42 TRPV1oncoprotein31.0000Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
43 TRPV4interactor100Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
44 UGGT2interactor21.0000Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
45 UGT1A10interactor100UDPGT (PF00201, IPR002213): UDP-glucoronosyl and UDP-glucosyl transferase
46 VCPprotein found in more fusions120.41822.933AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
47 ZNF512Binteractor100YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CLN5interactorCLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
2 DERL2interactorDER1 (PF04511, IPR007599): Der1-like family
3 DPEP2interactorPeptidase_M19 (PF01244, IPR008257): Membrane dipeptidase (Peptidase family M19)
4 FAM8A1interactorRDD (PF06271, IPR010432): RDD family
5 FBXO6interactorFBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
6 FOXRED2interactorPyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
7 KLK5oncoproteinTrypsin (PF00089, IPR001254, SM00020): Trypsin
8 OS9parental proteinDNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
9 SERPINA1oncoproteinSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
10 SERPINC1interactorSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
11 SERPINH1interactorSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
12 SERPINI1interactorSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
13 SYVN1interactorAlpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
14 UBE2J1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
15 ZPBP2interactorSp38 (PF07354, IPR010857): Zona-pellucida-binding protein (Sp38)

B a c k    t o    T o p ⇑