Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	96
The number (and %) of the onco-proteins	27 (28.12 %)
The number (and %) of the tumor suppressors	23 (23.96 %)
Total number of binary PPIs (saturation %)	421 (9.23 %)
The number (and %) of affected PPIs	95 (22.57 %)
The number of possible different fusions	20
PPI diameter	2
PPI radius	1
The average degree of PPI	7.917
Assortativity coefficient	-0.2809
The network average Clustering coefficient	0.519
The number (and %) of a zero Clustering coefficients	17 (17.71 %)
The number (and %) of a zero Betweenness Centrality	34 (35.42 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ACTA1,GAS7	All fusions : BG998390;
Proteins found in more fusions	ERBB3 (see 2 fusions); TPM2 (see 1 fusions); LGALS3 (see 2 fusions); ETV6 (see 1 fusions); USP25 (see 1 fusions); ACTG1 (see 4 fusions); TPM2/MYH9 (see 1 fusions); CBL (see 1 fusions); MCM2 (see 1 fusions); KAT5 (see 3 fusions); CUL7 (see 2 fusions); SHC1 (see 1 fusions); CUL1 (see 3 fusions); EP300 (see 1 fusions); HDAC4 (see 1 fusions); GC (see 1 fusions); PRKCE (see 3 fusions); ERRFI1 (see 1 fusions); CTNNBL1 (see 1 fusions);

List of the fusions

PPI for parental proteins: ACTA1,GAS7

All fusions

: BG998390;

Proteins found in more fusions

ERBB3 (see 2 fusions); TPM2 (see 1 fusions); LGALS3 (see 2 fusions); ETV6 (see 1 fusions); USP25 (see 1 fusions); ACTG1 (see 4 fusions); TPM2/MYH9 (see 1 fusions); CBL (see 1 fusions); MCM2 (see 1 fusions); KAT5 (see 3 fusions); CUL7 (see 2 fusions); SHC1 (see 1 fusions); CUL1 (see 3 fusions); EP300 (see 1 fusions); HDAC4 (see 1 fusions); GC (see 1 fusions); PRKCE (see 3 fusions); ERRFI1 (see 1 fusions); CTNNBL1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	BG998390	chimera	95	0.064	6955.144	Actin (PF00022, IPR004000, SM00268): Actin
2	ABL1	oncoprotein	9	0.571	7.733	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	ABLIM2	interactor	2	1.000	0	LIM (PF00412, IPR001781, SM00132): LIM domain VHP (PF02209, IPR003128, SM00153): Villin headpiece domain Med27 (PF11571, IPR021627): Mediator complex subunit 27 AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
4	ABLIM3	interactor	2	1.000	0	LIM (PF00412, IPR001781, SM00132): LIM domain VHP (PF02209, IPR003128, SM00153): Villin headpiece domain zf-HYPF (PF07503, IPR011125): HypF finger Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2 TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
5	ABRA	interactor	3	0.667	1.000	Costars (PF14705, IPR027817): Costars
6	ACTBL2	interactor	12	0.364	29.458	Actin (PF00022, IPR004000, SM00268): Actin
7	ACTG1	protein found in more fusions	28	0.234	220.382	Actin (PF00022, IPR004000, SM00268): Actin
8	AKT1	oncoprotein	12	0.255	32.319	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
9	AMOT	oncoprotein	2	0	0	FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162) Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
10	APC2	oncoprotein	1	0	0	APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
11	ARRB1	interactor	9	0.444	13.189	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
12	BIN1	suppressor	2	0	0	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
13	BRK1	interactor	5	0.900	0.500	DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
14	BTK	suppressor	6	0.400	4.000	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
15	CAPZA2	interactor	16	0.475	33.895	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
16	CBL	suppressor	11	0.578	10.789	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
17	CCT2	interactor	13	0.462	19.491	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18	CCT4	interactor	11	0.545	9.534	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19	CCT5	interactor	10	0.622	5.683	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
20	CDH2	interactor	2	1.000	0	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain Cadherin_3 (PF16184): Cadherin-like
21	CDK2	suppressor	23	0.390	79.544	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
22	CDKN2A	suppressor	12	0.394	25.424	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
23	CEP57	interactor	3	0.667	0.400	Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57 Tup_N (PF08581, IPR013890): Tup N-terminal CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 TRIQK (PF15168, IPR024842): Triple QxxK/R motif-containing protein family
24	CNN1	suppressor	2	1.000	0	Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
25	CTNNBL1	protein found in more fusions	2	0	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DASH_Dad4 (PF08650, IPR013959): DASH complex subunit Dad4 CTNNBL (PF08216, IPR013180, SM01156): Catenin-beta-like, Arm-motif containing nuclear Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
26	CUL1	suppressor	12	0.564	8.739	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27	CUL7	protein found in more fusions	12	0.418	17.979	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
28	DHX9	oncoprotein	12	0.379	23.806	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
29	DMAP1	interactor	7	0.905	0.733	DMAP1 (PF05499, IPR008468): DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like (PF16282, IPR032563): SANT/Myb-like domain of DAMP1
30	DMC1	interactor	2	0	0	Rad51 (PF08423, IPR013632): Rad51 HHH_5 (PF14520): Helix-hairpin-helix domain
31	DMD	suppressor	4	0.500	1.667	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EF-hand_2 (PF09068, IPR015153): EF hand EF-hand_3 (PF09069, IPR015154): EF-hand FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus IncA (PF04156, IPR007285): IncA protein Spectrin (PF00435, IPR002017): Spectrin repeat WW (PF00397, IPR001202, SM00456): WW domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DinB_2 (PF12867, IPR024775): DinB superfamily CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
32	DNASE1	interactor	1	0	0	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
33	DNMBP	interactor	3	0.667	1.000	BAR (PF03114, IPR004148, SM00721): BAR domain HR1 (PF02185, IPR011072, SM00742): Hr1 repeat IncA (PF04156, IPR007285): IncA protein RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
34	EP300	oncoprotein	12	0.327	25.907	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
35	ERBB3	oncoprotein	8	0.476	8.400	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
36	ERRFI1	suppressor	6	0.700	1.233	GTPase_binding (PF09027, IPR015116): GTPase binding Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
37	ETV6	suppressor	3	1.000	0	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
38	FSCN1	oncoprotein	4	1.000	0	Fascin (PF06268, IPR022768): Fascin domain
39	GC	protein found in more fusions	2	0	0	VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
40	HDAC1	suppressor	15	0.308	45.490	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
41	HDAC4	oncoprotein	4	0.667	1.000	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
42	HDAC8	interactor	1	0	0	DNase-RNase (PF02577, IPR003729): Bifunctional nuclease Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
43	HSPB2	interactor	4	1.000	0	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
44	HTRA2	suppressor	3	1.000	0	Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32 PDZ_2 (PF13180, IPR001478): PDZ domain Trypsin_2 (PF13365): Trypsin-like peptidase domain
45	ISG15	suppressor	7	0.333	8.079	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
46	KAT5	suppressor	13	0.470	26.967	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
47	KLHL20	interactor	2	0	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
48	LGALS3	oncoprotein	3	1.000	0	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
49	LIMA1	suppressor	17	0.529	30.383	LIM (PF00412, IPR001781, SM00132): LIM domain ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
50	LRCH3	interactor	5	0.600	2.222	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
51	MARK4	oncoprotein	3	1.000	0	KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
52	MCM2	oncoprotein	19	0.333	58.548	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
53	MIB2	oncoprotein	1	0	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat KOW (PF00467, IPR005824, SM00739): KOW motif MIB_HERC2 (PF06701, IPR010606): Mib_herc2 TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
54	MLPH	interactor	1	0	0	Dpy-30 (PF05186, IPR007858): Dpy-30 motif Rab_eff_C (PF04698, IPR006788): Rab effector MyRIP/melanophilin C-terminus FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3
55	MORF4L1	interactor	9	0.786	2.733	MRG (PF05712, IPR026541): MRG Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
56	MORF4L2	interactor	7	0.905	0.733	MRG (PF05712, IPR026541): MRG
57	MRGBP	interactor	6	1.000	0	Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7
58	MYH9	suppressor	25	0.327	135.998	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
59	MYO18A	interactor	13	0.679	11.818	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_tail_1 (PF01576, IPR002928): Myosin tail PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
60	MYO1C	interactor	18	0.471	45.964	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
61	NCKAP1	interactor	6	0.533	5.533	Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
62	NCOA3	oncoprotein	6	0.467	5.500	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
63	NRAP	interactor	2	1.000	0	LIM (PF00412, IPR001781, SM00132): LIM domain Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat
64	NTRK1	oncoprotein	28	0.265	183.249	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
65	OBSL1	interactor	11	0.556	7.162	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
66	PCYT1B	interactor	1	0	0	ApoC-I (PF04691, IPR006781): Apolipoprotein C-I (ApoC-1) CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like FTO_CTD (PF12934, IPR024366): FTO C-terminal domain
67	PHACTR1	interactor	2	1.000	0	BAF1_ABF1 (PF04684, IPR006774): BAF1 / ABF1 chromatin reorganising factor FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) RPEL (PF02755, IPR004018, SM00707): RPEL repeat
68	POLR1B	interactor	4	0.833	0.500	RNA_pol_Rpa2_4 (PF06883, IPR009674): RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
69	POU5F1	oncoprotein	4	1.000	0	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
70	PPP1CA	suppressor	16	0.442	39.702	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
71	PPP1CB	interactor	17	0.544	27.702	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
72	PPP1R9B	interactor	8	0.679	3.224	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Stm1_N (PF09598, IPR019084): Stm1 TSC22 (PF01166, IPR000580): TSC-22/dip/bun family DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) PRIMA1 (PF16101): Proline-rich membrane anchor 1 NuDC (PF16273, IPR032572): Nuclear distribution C domain
73	PRKCE	suppressor	5	0.500	1.667	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
74	RELA	oncoprotein	9	0.500	9.117	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
75	RPS6KB1	interactor	5	0.667	1.333	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
76	RPS6KB2	interactor	10	0.289	19.955	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
77	RRN3	interactor	4	0.833	0.500	RRN3 (PF05327, IPR007991): RNA polymerase I specific transcription initiation factor RRN3
78	SFN	suppressor	11	0.333	20.900	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
79	SHC1	oncoprotein	13	0.470	20.555	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
80	SMARCD1	interactor	3	0.667	0.250	ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit DivIC (PF04977, IPR007060): Septum formation initiator SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
81	SPTAN1	oncoprotein	19	0.421	61.624	EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
82	TAGLN	suppressor	2	1.000	0	Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
83	TES	suppressor	6	1.000	0	LIM (PF00412, IPR001781, SM00132): LIM domain PET (PF06297, IPR010442): PET Domain PSCyt3 (PF07627, IPR013039): Protein of unknown function (DUF1588) Ig_Tie2_1 (PF10430, IPR018941): Tie-2 Ig-like domain 1
84	TNNI3K	interactor	1	0	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
85	TPM2	protein found in more fusions	8	0.762	1.915	DASH_Spc19 (PF08287, IPR013251): Spc19 Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
86	TRAF3IP1	interactor	4	0.667	1.167	MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
87	TRIM55	interactor	4	0.667	1.000	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein NABP (PF07990, IPR012940): Nucleic acid binding protein NABP zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
88	TRIM63	interactor	4	0.667	1.000	DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) KIP1 (PF07765, IPR011684): KIP1-like protein RED_C (PF07807, IPR012492): RED-like protein C-terminal region zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
89	TRIP6	interactor	1	0	0	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region LIM (PF00412, IPR001781, SM00132): LIM domain
90	TSC1	suppressor	3	1.000	0	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein
91	UBAC2	interactor	1	0	0	Rhomboid (PF01694, IPR022764): Rhomboid family UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
92	UBE3A	oncoprotein	6	0.700	1.467	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
93	UBL4A	interactor	3	0.667	0.200	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
94	USP25	protein found in more fusions	2	0	0	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase UBA_4 (PF14555): UBA-like domain
95	VIM	suppressor	14	0.308	36.896	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
96	XPO6	interactor	1	0	0	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ABI1	oncoprotein	Abi_HHR (PF07815, IPR012849): Abl-interactor HHR Cytochrom_B558a (PF05038, IPR007732): Cytochrome Cytochrome b558 alpha-subunit SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124) PRIMA1 (PF16101): Proline-rich membrane anchor 1 ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
2	ACTA1	parental protein	Actin (PF00022, IPR004000, SM00268): Actin
3	ANXA8	interactor	Annexin (PF00191, IPR018502, SM00335): Annexin
4	APBB1IP	interactor	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain MLANA (PF14991, IPR029242): Protein melan-A SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
5	ATXN1L	interactor	AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
6	CFL1	interactor	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
7	COTL1	oncoprotein	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
8	CREB3L2	oncoprotein	bZIP_1 (PF00170, IPR004827): bZIP transcription factor bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
9	CSNK1A1	suppressor	Pkinase (PF00069, IPR000719): Protein kinase domain
10	CYFIP1	interactor	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
11	CYFIP2	interactor	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family zf-CW (PF07496, IPR011124): CW-type Zinc Finger
12	DIAPH1	interactor	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Drf_DAD (PF06345, IPR010465): DRF Autoregulatory Domain Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1 Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain Glucan_synthase (PF02364, IPR003440): 1,3-beta-glucan synthase component Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
13	DSTN	interactor	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
14	DVL1P1	interactor	NA
15	FMNL1	interactor	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain SlyX (PF04102, IPR007236): SlyX FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
16	FOXRED2	interactor	Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
17	GAPDH	oncoprotein	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
18	GAS7	parental protein	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain WW (PF00397, IPR001202, SM00456): WW domain YscO (PF07321, IPR009929): Type III secretion protein YscO SH3_9 (PF14604, IPR001452): Variant SH3 domain WW_FCH_linker (PF16623): Unstructured linker region between on GAS7 protein
19	GSN	suppressor	Gelsolin (PF00626, IPR007123): Gelsolin repeat
20	HNRNPU	interactor	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
21	KHDRBS1	interactor	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
22	MAPK14	oncoprotein	Pkinase (PF00069, IPR000719): Protein kinase domain
23	NCKAP1L	interactor	Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
24	PACSIN1	interactor	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605) DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446) SH3_9 (PF14604, IPR001452): Variant SH3 domain NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
25	PFDN1	interactor	Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
26	PPP1R1A	oncoprotein	DARPP-32 (PF05395, IPR008466): Protein phosphatase inhibitor 1/DARPP-32
27	PTPN22	interactor	Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
28	RPLP0	interactor	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
29	SCIN	interactor	Gelsolin (PF00626, IPR007123): Gelsolin repeat
30	SF1	interactor	UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
31	SF3A1	interactor	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
32	SFPQ	oncoprotein	GRP (PF07172, IPR010800): Glycine rich protein family Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
33	SMARCB1	suppressor	SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
34	SNCA	interactor	Synuclein (PF01387, IPR001058): Synuclein
35	TMSB4X	interactor	Thymosin (PF01290, IPR001152, SM00152): Thymosin beta-4 family
36	TMSB4Y	interactor	Thymosin (PF01290, IPR001152, SM00152): Thymosin beta-4 family
37	WAS	oncoprotein	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif PRIMA1 (PF16101): Proline-rich membrane anchor 1
38	WASF2	oncoprotein	RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase WH2 (PF02205, IPR003124, SM00246): WH2 motif WASH_WAHD (PF11945, IPR021854): WAHD domain of WASH complex
39	WDYHV1	interactor	Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase

B a c k t o T o p ⇑

Fusion ID: Protein names:	BG998390
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:	all	affected	independent (normal)	missing	nothing (blank)
Chimeric state:	ordinary fusion	big fusion

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