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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BG981391 is the fusion of parental proteins PIGR, DNAJC5 (from a repository: Wed Mar 8 02:34:12 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins4 (26.67 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)16 (15.24 %)
The number (and %) of affected PPIs14 (87.50 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI1.867
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients15 (100.00 %)
The number (and %) of a zero Betweenness Centrality14 (93.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: DNAJC5,PIGR All fusions
: BG981391;
Proteins found in more fusions CDK6 (see 1 fusions); SGK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BG981391chimera140182.000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
2 CDK6suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
3 FN3KRPinteractor100Fructosamin_kin (PF03881, IPR016477): Fructosamine kinase
4 GTF2Binteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
5 HVCN1interactor100Ion_trans (PF00520, IPR005821): Ion transport protein
SlyX (PF04102, IPR007236): SlyX
VGPC1_C (PF16799, IPR031844): C-terminal membrane-localisation domain of ion-channel, VCN1
6 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
7 MAPK15interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
8 MIS12interactor100DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
9 RAB3Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)
10 RAD21oncoprotein100Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
11 SGK1oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
12 SMAD6interactor100MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
13 SSFA2interactor100KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain
SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
14 TMEM237interactor100TMEM237 (PF15383, IPR029409): Transmembrane protein 237
15 UCP2interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ATP6V1B1interactorATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
2 CFTRsuppressorABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
3 DNAJC5parental proteinDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Baculo_F (PF12259, IPR022048): Baculovirus F protein
4 ECE1interactorPeptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
5 HSPA4interactorHerpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
6 PIGRparental proteinV-set (PF07686, IPR013106): Immunoglobulin V-set domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
7 PTGFRinteractor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF3784 (PF12650, IPR017259): Domain of unknown function (DUF3784)
8 STUB1suppressorU-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
9 VCLoncoproteinVinculin (PF01044, IPR006077): Vinculin family

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