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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BG978110 is the fusion of parental proteins GSTP1, PSMB1 (from a repository: Sat Dec 17 13:25:42 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)121
The number (and %) of the onco-proteins35 (28.93 %)
The number (and %) of the tumor suppressors14 (11.57 %)
Total number of binary PPIs (saturation %)1454 (20.03 %)
The number (and %) of affected PPIs120 (8.25 %)
The number of possible different fusions23
PPI diameter2
PPI radius1
The average degree of PPI23.157
Assortativity coefficient-0.1663
The network average Clustering coefficient0.651
The number (and %) of a zero Clustering coefficients4 (3.31 %)
The number (and %) of a zero Betweenness Centrality19 (15.70 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: Unknown,PSMB1 All fusions
: BG978110;
Proteins found in more fusions PSMC2 (see 1 fusions); UBE2O (see 1 fusions); MAPK1 (see 1 fusions); NTRK1/RPL7A (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); PSMB3 (see 1 fusions); MAP3K1 (see 1 fusions); VHL (see 1 fusions); MYC (see 1 fusions); PSME3 (see 2 fusions); FUS/PSMB7 (see 1 fusions); PSMB7 (see 2 fusions); PSMA7 (see 2 fusions); COPS5 (see 1 fusions); FANCG (see 1 fusions); SRSF2 (see 1 fusions); BAG3 (see 4 fusions); FKBP8 (see 1 fusions); MCM2 (see 1 fusions); EPAS1 (see 1 fusions); PSMC5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BG978110chimera1200.1796532.980Proteasome (PF00227, IPR001353): Proteasome subunit
2 ADRM1interactor360.9631.739Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor
GET2 (PF08690, IPR028143): GET complex subunit GET2
RPN13_C (PF16550, IPR032368): UCH-binding domain
3 AMFRoncoprotein240.77917.521CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 AP3M1interactor80.9290.129Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5 APPBP2interactor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
6 BAG3oncoprotein240.65240.021BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
7 BCL3oncoprotein21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
8 CASP4interactor21.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
9 CCT5interactor150.41923.161Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CDK2suppressor220.43354.909Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
11 CDKN1Bsuppressor50.7001.583CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
12 CFTRsuppressor100.8610.490ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
13 CLIC4oncoprotein100.7112.967GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
14 COPS5protein found in more fusions220.34378.070JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15 CUL2suppressor150.39038.526Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
16 CUL3protein found in more fusions280.325122.370Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
17 CUL7protein found in more fusions150.33018.902ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
18 DCP2interactor100DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
19 DSTYKinteractor21.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
20 EPAS1suppressor60.6002.233Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
21 FANCGsuppressor200BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
22 FBXL12interactor21.0000F-box-like (PF12937, IPR001810): F-box-like
23 FBXO28interactor60.4006.182Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
F-box (PF00646, IPR001810, SM00256): F-box domain
FAM76 (PF16046, IPR032017): FAM76 protein
24 FKBP8protein found in more fusions330.85122.662FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
25 FN1oncoprotein240.43557.867fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
26 FOXD4interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
27 FUSsuppressor190.32741.081Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
28 HAUS2interactor30.6671.000DpnII (PF04556, IPR007637): DpnII restriction endonuclease
HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
29 HECW2interactor60.7001.750C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
30 HNRNPA2B1oncoprotein230.38356.342RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
31 IQCB1interactor160.8503.984DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
32 ISG15suppressor60.5332.485ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33 ITGA4interactor200.55620.471FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
34 KIFC3oncoprotein70.3337.833Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
35 KRT13interactor50.7001.233Filament (PF00038, IPR001664): Intermediate filament protein
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
Keratin_2_head (PF16208, IPR032444): Keratin type II head
36 KRT15interactor40.6671.500Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
37 KRT31interactor60.4674.045Filament (PF00038, IPR001664): Intermediate filament protein
38 LIG4interactor40.8330.182APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
39 MAP3K1oncoprotein90.5715.530zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
40 MAPK1oncoprotein80.4763.462Pkinase (PF00069, IPR000719): Protein kinase domain
41 MAPRE3interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
42 MCM2oncoprotein290.354114.790AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
43 MED4interactor90.27821.754Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
44 MID1oncoprotein141.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
45 MYConcoprotein300.500110.899HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
46 NOTCH2suppressor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
47 NOTCH2NLinteractor31.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
48 NTRK1oncoprotein520.367371.742I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
49 PARK2suppressor450.625184.964IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
50 PASKinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
PAS_8 (PF13188, IPR000014): PAS domain
PAS_9 (PF13426, IPR000014): PAS domain
51 PEX19interactor41.0000Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
52 PGK1interactor150.48617.015PGK (PF00162, IPR001576): Phosphoglycerate kinase
53 PLK1suppressor190.67818.256Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
54 PNO1interactor21.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
55 POMPinteractor210.9531.249UMP1 (PF05348, IPR008012): Proteasome maturation factor UMP1
56 PPP4R3Ainteractor50.6002.389Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
57 PSEN1oncoprotein60.5005.000Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
58 PSMA1interactor650.472462.481Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
59 PSMA2interactor570.602154.497Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
60 PSMA3interactor590.578140.262Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
61 PSMA4interactor520.66179.404Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
62 PSMA5oncoprotein620.509261.887Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
63 PSMA6interactor630.494317.703Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
64 PSMA7protein found in more fusions610.534217.074Proteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
65 PSMA8interactor310.9274.665Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
Myb_DNA-bind_5 (PF13873, IPR028002): Myb/SANT-like DNA-binding domain
66 PSMB10interactor160.8258.504Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
67 PSMB2interactor510.644119.643Proteasome (PF00227, IPR001353): Proteasome subunit
68 PSMB3protein found in more fusions620.512283.391Proteasome (PF00227, IPR001353): Proteasome subunit
69 PSMB4interactor540.604125.834Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
70 PSMB5interactor530.615102.368Proteasome (PF00227, IPR001353): Proteasome subunit
71 PSMB6interactor500.66967.800DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Proteasome (PF00227, IPR001353): Proteasome subunit
72 PSMB7protein found in more fusions500.68383.914Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
73 PSMB8interactor400.86215.654Proteasome (PF00227, IPR001353): Proteasome subunit
74 PSMB9interactor410.82417.860Proteasome (PF00227, IPR001353): Proteasome subunit
75 PSMC1interactor440.80528.061AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
76 PSMC2protein found in more fusions480.76731.576AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
77 PSMC3interactor450.76786.578AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
78 PSMC4interactor440.79364.884AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
79 PSMC5protein found in more fusions490.71776.282AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
80 PSMC6interactor420.83719.241AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
81 PSMD1interactor450.77854.737PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
82 PSMD11interactor450.72272.759DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
83 PSMD12interactor410.87118.316Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
84 PSMD13interactor410.84424.984Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase
PCI (PF01399, IPR000717, SM00088): PCI domain
85 PSMD14interactor440.82718.096JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
86 PSMD2oncoprotein530.623123.368PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
87 PSMD3interactor480.70264.197Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
88 PSMD4interactor410.82446.882UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
89 PSMD6interactor450.77451.413RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
90 PSMD7interactor430.80444.046JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
91 PSME1interactor290.8527.796PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
92 PSME2interactor310.80014.484PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
93 PSME3protein found in more fusions290.72030.346PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
94 PSME4interactor190.8256.275Filament (PF00038, IPR001664): Intermediate filament protein
HEAT (PF02985, IPR000357): HEAT repeat
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
BLM10_mid (PF16507, IPR032430): Proteasome-substrate-size regulator, mid region
95 PSMG3interactor111.0000PAC3 (PF10178, IPR018788): Proteasome assembly chaperone 3
96 PTNoncoprotein50.6670.287PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
97 PYCRLinteractor100.6942.165F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
P5CR_dimer (PF14748, IPR029036): Pyrroline-5-carboxylate reductase dimerisation
98 RAD23Aoncoprotein390.74195.583UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
99 RBM8Ainteractor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
100 RIOK3interactor21.0000RIO1 (PF01163, IPR018934): RIO1 family
101 RPL10Ainteractor140.57110.169Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
102 RPL24interactor120.51516.803MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
103 RPL5suppressor160.51424.937Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
104 RPL7Aprotein found in more fusions130.53810.641Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
105 RPP30interactor40.5000.405RNase_P_p30 (PF01876, IPR002738): RNase P subunit p30
106 RPP38interactor81.0000Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
107 SEC13interactor70.4674.617WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
108 SF3A1interactor120.6069.179TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Surp (PF01805, IPR000061, SM00648): Surp module
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
109 SLX1Binteractor150.9430.762GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
110 SRSF2oncoprotein160.41929.380RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
111 SUGT1interactor80.6072.021CheC (PF04509, IPR007597): CheC-like family
CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
112 SYVN1interactor170.9750.295Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
113 TRAF1oncoprotein60.6002.233HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
114 TRAF2interactor110.31125.150MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
115 TRIM27oncoprotein90.42910.686IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
116 UBE2Oprotein found in more fusions80.3818.233BUD22 (PF09073, IPR015158): BUD22
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
117 UBE4Bsuppressor40.6670.074DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
118 UCHL5oncoprotein380.88130.983Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
119 UNKinteractor40.5002.286MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
120 VCAM1interactor210.52930.608C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
121 VHLsuppressor170.39231.970Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACTA2interactorActin (PF00022, IPR004000, SM00268): Actin
2 ACY1suppressorPeptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
3 ASNA1interactorArsA_ATPase (PF02374, IPR025723): Anion-transporting ATPase
4 ATF2oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
5 DDB2suppressorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
6 EXOSC6interactorRNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
7 FANCConcoproteinFanconi_C (PF02106, IPR000686): Fanconi anaemia group C protein
8 GABPB1oncoproteinAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_4 (PF13637): Ankyrin repeats (many copies)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
9 GSTP1parental proteinGST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
10 GSTT2interactorGST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
11 GSTT2BinteractorGST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
12 HNRNPA1interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
13 HSD17B10interactoradh_short (PF00106, IPR002198): short chain dehydrogenase
14 INSIG2interactorINSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
15 KRTAP10-3interactorKeratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
16 KRTAP10-7interactorKeratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
17 KRTAP10-9interactorKeratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
18 MAPK8oncoproteinDUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
19 MLH1suppressorDNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
20 MRPS9interactorRibosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
21 PCK1interactorPEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
22 PSMB1parental proteinProteasome (PF00227, IPR001353): Proteasome subunit
23 PSMD5interactorProteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
24 PSMD8interactorCSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
25 RBMXsuppressorRBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 RPS15AinteractorRibosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
27 RPS23interactorRibosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
28 SCAF1oncoproteinCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
Med8 (PF10232, IPR019364): Mediator of RNA polymerase II transcription complex subunit 8
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FAM220 (PF15487, IPR029155): FAM220 family
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
DUF4778 (PF16008, IPR031958): Domain of unknown function (DUF4778)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
29 SERPINB2interactorSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
30 SERPINE1interactorSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
31 SHFM1interactorCLLAC (PF15675, IPR031379): CLLAC-motif containing domain
32 SIRT7interactorDUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
33 SNX3interactorPX (PF00787, IPR001683, SM00312): PX domain
34 TGM2interactorTransglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
35 TXNL4AinteractorDIM1 (PF02966, IPR004123): Mitosis protein DIM1
36 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
37 UBE2AinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
38 UBE2V1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
39 UFM1interactorUfm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
40 ZNF518AinteractorCBP4 (PF07960, IPR012420): CBP4
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Fer4_9 (PF13187, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain

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