Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BG928901 is the fusion of parental proteins TCEAL2, CHP1 (from a repository: Sat Nov 4 05:03:33 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins6 (60.00 %)
The number (and %) of the tumor suppressors1 (10.00 %)
Total number of binary PPIs (saturation %)23 (51.11 %)
The number (and %) of affected PPIs9 (39.13 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI3.400
Assortativity coefficient-0.2936
The network average Clustering coefficient0.522
The number (and %) of a zero Clustering coefficients2 (20.00 %)
The number (and %) of a zero Betweenness Centrality3 (30.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CHP1,TCEAL2 All fusions
: BG928901;
Proteins found in more fusions NEDD4L (see 3 fusions); APP (see 4 fusions); USP11 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BG928901chimera90.22247.000BEX (PF04538, IPR021156): Brain expressed X-linked like family
2 APPprotein found in more fusions40.6671.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 AURKAoncoprotein40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
4 CUL4Boncoprotein40.6672.000Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
5 ERBB2oncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
6 NEDD4Lsuppressor200WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
7 NXF1interactor50.6672.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
8 SLC9A1interactor100DUF1427 (PF07235, IPR009872): Protein of unknown function (DUF1427)
LHC (PF00556, IPR000066): Antenna complex alpha/beta subunit
Na_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
9 TCEAL4interactor30.6671.000BEX (PF04538, IPR021156): Brain expressed X-linked like family
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
10 USP11protein found in more fusions50.6672.000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CHP1parental proteinEF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
3 FBXO25suppressorElongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
4 MOV10interactorAAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
5 PRSS23interactorTrypsin (PF00089, IPR001254, SM00020): Trypsin
6 SHMT2interactorSHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
7 SLC9A2oncoproteinNa_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
8 SLC9A3interactorNa_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
9 SLC9A4interactorNa_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
10 SLC9A5interactorNa_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
11 TCEAL1interactorBEX (PF04538, IPR021156): Brain expressed X-linked like family
12 TCEAL2parental proteinBEX (PF04538, IPR021156): Brain expressed X-linked like family
13 TMEM216interactorTransmemb_17 (PF09799, IPR019184): Predicted membrane protein
14 XPO1interactorCRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑