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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BG827779 is the fusion of parental proteins NELFB (from a repository: Mon Dec 5 06:16:07 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins15 (34.09 %)
The number (and %) of the tumor suppressors3 (6.82 %)
Total number of binary PPIs (saturation %)270 (28.54 %)
The number (and %) of affected PPIs43 (15.93 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI11.682
Assortativity coefficient-0.0857
The network average Clustering coefficient0.694
The number (and %) of a zero Clustering coefficients2 (4.55 %)
The number (and %) of a zero Betweenness Centrality8 (18.18 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: NELFB All fusions
: BG827779;
Proteins found in more fusions PTBP1 (see 1 fusions); FOS (see 4 fusions); POLR2A (see 2 fusions); MSH2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BG827779chimera430.237822.458COBRA1 (PF06209, IPR010405): Cofactor of BRCA1 (COBRA1)
2 ABCF1interactor170.8245.199ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
ABC_tran_Xtn (PF12848, IPR032781): ABC transporter
AAA_18 (PF13238): AAA domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
3 ATP1A1interactor60.7332.667Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
4 BRCA1suppressor130.43920.569BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
5 CCT8interactor41.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
6 CEBPEinteractor41.0000Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
7 DDX1oncoprotein170.7877.368DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8 DENRoncoprotein100SUI1 (PF01253, IPR001950): Translation initiation factor SUI1
9 DHX9oncoprotein180.62727.394DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
10 DIMT1interactor150.7338.281RrnaAD (PF00398, IPR001737, SM00650): Ribosomal RNA adenine dimethylase
11 EDC4interactor120.9390.630DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
12 EIF2B2interactor170.7946.336IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
13 EIF2B3interactor160.8009.308NTP_transferase (PF00483, IPR005835): Nucleotidyl transferase
NAGPA (PF09992, IPR018711): Phosphodiester glycosidase
DUF4954 (PF16314, IPR032533): Domain of unknown function (DUF4954)
14 EIF3Concoprotein40.8330.154eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
15 ELP6interactor100ELP6 (PF09807, IPR018627): Elongation complex protein 6
16 ESR1suppressor180.33161.167Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
17 FKBP3interactor150.8195.317FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
18 FOSoncoprotein50.8330.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
19 HNRNPUinteractor220.56744.404CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
20 IGF2BP3interactor180.7589.968RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
21 ILF2interactor220.61533.731DZF (PF07528, IPR006561, SM00572): DZF domain
22 JUNoncoprotein70.6674.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
23 KHDRBS3interactor31.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
24 MRE11Aoncoprotein160.77111.514APG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
25 MSH2suppressor80.6193.802MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
26 NCBP1interactor51.0000MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
27 NELFAinteractor100.57811.300CathepsinC_exc (PF08773, IPR014882): Cathepsin C exclusion domain
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
28 NELFCDoncoprotein70.7622.500TH1 (PF04858, IPR006942): TH1 protein
29 NELFEinteractor70.8101.733DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
FLO_LFY (PF01698, IPR002910): Floricaula / Leafy protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
30 NMT1oncoprotein190.73711.750NMT (PF01233, IPR022676): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
NMT_C (PF02799, IPR022677): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
31 NTRK1oncoprotein290.312193.168I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32 PA2G4interactor90.7222.420Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
33 POLR2Aprotein found in more fusions110.5789.617RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
34 POLR2Cinteractor90.6436.133RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
35 PTBP1oncoprotein100.8331.141RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
36 RAD51interactor51.0000Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
37 RFC4interactor170.7949.022AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
38 RPL23Ainteractor100.7563.142Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
39 RPN1oncoprotein70.6195.067Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
40 SUPT5Hinteractor80.6075.002KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
41 SYNCRIPinteractor100.62211.100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
42 YBX1oncoprotein150.60015.152CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
43 YBX3interactor140.8244.817CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
44 YWHABinteractor31.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALDH3A2interactorAldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
2 HSPA9oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
3 MAPK6oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
4 MGST1interactorMAPEG (PF01124, IPR001129): MAPEG family
5 NELFBparental proteinCOBRA1 (PF06209, IPR010405): Cofactor of BRCA1 (COBRA1)

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