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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BG756114 is the fusion of parental proteins VGLL4, UBE2E3 (from a repository: Thu Feb 23 04:54:35 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)86
The number (and %) of the onco-proteins30 (34.88 %)
The number (and %) of the tumor suppressors14 (16.28 %)
Total number of binary PPIs (saturation %)295 (8.07 %)
The number (and %) of affected PPIs85 (28.81 %)
The number of possible different fusions23
PPI diameter2
PPI radius1
The average degree of PPI5.512
Assortativity coefficient-0.3400
The network average Clustering coefficient0.604
The number (and %) of a zero Clustering coefficients12 (13.95 %)
The number (and %) of a zero Betweenness Centrality35 (40.70 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: VGLL4,UBE2E3 All fusions
: BG756114;
Proteins found in more fusions ZNRF1 (see 1 fusions); NEDD4L (see 3 fusions); RNF111 (see 1 fusions); ARIH2 (see 2 fusions); RNF11 (see 1 fusions); CUL4A (see 4 fusions); STUB1 (see 1 fusions); TRIM27/MDM2 (see 1 fusions); RNF114 (see 1 fusions); HTT (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); ATXN1 (see 3 fusions); UBC (see 1 fusions); SIAH1 (see 4 fusions); DDB1 (see 2 fusions); TBL1X (see 2 fusions); RING1 (see 1 fusions); CDK6 (see 1 fusions); RANGAP1 (see 2 fusions); DTX3L (see 2 fusions); UBA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BG756114chimera850.0435706.433CDC45 (PF02724, IPR003874): CDC45-like protein
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
2 ARID3Ainteractor30.6670.200ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
Nop14 (PF04147, IPR007276): Nop14-like family
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
3 ARIH2protein found in more fusions51.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
4 ATXN1protein found in more fusions80.28613.667AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
5 BARD1suppressor50.5002.167BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
6 BRCA1suppressor90.32115.067BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
7 CADPS2oncoprotein100DUF1041 (PF06292, IPR010439, SM01145): Domain of Unknown Function (DUF1041)
PH (PF00169, IPR001849, SM00233): PH domain
8 CCDC121interactor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
DUF4515 (PF14988, IPR032777): Domain of unknown function (DUF4515)
9 CDK6suppressor40.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
10 CHFRsuppressor31.0000FHA (PF00498, IPR000253, SM00240): FHA domain
Glyco_hydro_92 (PF07971, IPR012939): Glycosyl hydrolase family 92
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
LAX (PF15681, IPR031393): Lymphocyte activation family X
11 CNOT4interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
12 CUL1suppressor120.49119.267Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
13 CUL3protein found in more fusions170.29270.500Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
14 CUL4Aprotein found in more fusions90.7862.400Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
15 DDB1protein found in more fusions110.60010.633CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
16 DTLinteractor50.9000.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
17 DTX3oncoprotein30.6671.000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
18 DTX3Lprotein found in more fusions50.6671.667KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
19 DZIP3interactor31.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
20 ELAVL1oncoprotein270.105273.067RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 ETV5oncoprotein30.6670.500Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
22 FBXO25suppressor31.0000Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
23 FSD1interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
DUF4945 (PF16303, IPR032544): Domain of unknown function (DUF4945)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
24 HERC4interactor31.0000RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
25 HTTprotein found in more fusions50.5002.500HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
26 IPO11interactor21.0000DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
27 ITCHinteractor100.41715.433C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
28 KLHL42interactor21.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
29 MARCH5interactor200DUF2517 (PF10725, IPR019663): Protein of unknown function (DUF2517)
RINGv (PF12906, IPR011016, SM00744): RING-variant domain
30 MDM2oncoprotein150.30850.867Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
31 MID1oncoprotein60.4003.600Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
32 MID2interactor70.4007.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
33 MKRN3oncoprotein40.6671.000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-3CxxC_2 (PF17180): Zinc-binding domain
34 MUL1interactor31.0000DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
GIDE (PF12483, IPR022170): E3 Ubiquitin ligase
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
35 NEDD4Lsuppressor50.6670.867WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
36 NFE2L2oncoprotein50.7001.400bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
37 NKD2interactor21.0000PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
38 OTUB1interactor50.7002.000Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
39 RANGAP1protein found in more fusions40.6671.000RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
40 RBX1oncoprotein100.52810.900zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
41 RC3H2interactor40.6670.200Xin (PF08043, IPR012510): Xin repeat
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
42 RCBTB1interactor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
43 RCBTB2interactor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
44 RDH12interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
45 RFWD3interactor30.6670.400OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
46 RING1protein found in more fusions31.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
47 RMND5Boncoprotein100Sec15 (PF04091, IPR007225): Exocyst complex subunit Sec15-like
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
48 RNF10interactor30.6670.667GCS2 (PF04107, IPR006336): Glutamate-cysteine ligase family 2(GCS2)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
RNA_pol_Rpb2_5 (PF04567, IPR007647): RNA polymerase Rpb2, domain 5
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
49 RNF11protein found in more fusions60.7001.833zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
50 RNF111suppressor40.6670.667zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
51 RNF114protein found in more fusions50.6672.000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
52 RNF115interactor40.6670.200Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zinc_ribbon_9 (PF14369): zinc-ribbon
53 RNF13interactor100DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
54 RNF130interactor21.0000PA (PF02225, IPR003137): PA domain
PspB (PF06667, IPR009554): Phage shock protein B
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
55 RNF14interactor200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
RWD (PF05773, IPR006575, SM00591): RWD domain
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
56 RNF150interactor21.0000PA (PF02225, IPR003137): PA domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PspB (PF06667, IPR009554): Phage shock protein B
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
57 RNF165interactor21.0000zf-P11 (PF03854, IPR003224): P-11 zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
58 RNF166interactor30.6671.000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
59 RNF167interactor200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Glucos_trans_II (PF14264, IPR025686): Glucosyl transferase GtrII
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
60 RNF185interactor41.0000zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
61 RNF2interactor130.30339.600zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
62 RNF25interactor50.6672.000RWD (PF05773, IPR006575, SM00591): RWD domain
Sin_N (PF04801, IPR006886): Sin-like protein conserved region
XK-related (PF09815, IPR018629): XK-related protein
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
63 RNF4interactor60.5003.333Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
64 RNF43oncoprotein200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
65 RNF5interactor41.0000zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
66 RNF8suppressor50.6671.667FHA (PF00498, IPR000253, SM00240): FHA domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
67 SIAH1suppressor60.5004.500Sina (PF03145, IPR018121): Seven in absentia protein family
68 SPOPsuppressor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
MATH (PF00917, IPR002083, SM00061): MATH domain
69 SPRY2suppressor40.6670.667KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
70 STUB1suppressor50.6671.500U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
71 TARDBPinteractor90.35713.067RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
72 TBL1Xprotein found in more fusions50.6671.333K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
73 TBL1XR1oncoprotein40.8330.500LisH (PF08513, IPR013720, SM00667): LisH
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
74 TRIM2interactor21.0000Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Caskin-tail (PF16632, IPR032117): C-terminal region of Caskin
DUF5128 (PF17170): 6-bladed beta-propeller
75 TRIM27oncoprotein110.40020.900IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
76 TRIM32suppressor70.5335.400NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
77 TRIM37oncoprotein31.0000MATH (PF00917, IPR002083, SM00061): MATH domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
DUF5071 (PF16804, IPR031837): Domain of unknown function (DUF5071)
78 TRIM38interactor40.6670.667DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
79 TRIM39interactor40.6671.000Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
80 TRIM45interactor31.0000ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
81 TRIM50interactor100Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
SPRY (PF00622, IPR003877, SM00449): SPRY domain
Trm112p (PF03966, IPR005651): Trm112p-like protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
82 UBA1protein found in more fusions60.9000.400ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
83 UBCprotein found in more fusions370.111517.700ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
84 WWP2interactor50.8330.667WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
85 ZNRF1protein found in more fusions31.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
RNF220 (PF15926, IPR031824): E3 ubiquitin-protein ligase RNF220
86 ZNRF4interactor100PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 DDA1interactorDDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
2 DET1interactorDet1 (PF09737, IPR019138): De-etiolated protein 1 Det1
3 IRF2BP1interactorzf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
4 IRF2BP2oncoproteinzf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Bd3614_N (PF14442, IPR025854): Bd3614-like deaminase N-terminal
5 IRF2BPLinteractorCalpain_inhib (PF00748, IPR001259): Calpain inhibitor
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
6 MEF2AoncoproteinTFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
7 RNF181interactorAhpC-TSA (PF00578, IPR000866): AhpC/TSA family
8 TEAD1interactorTEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
9 TEAD3interactorTEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
10 TEAD4interactorTEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
11 TERF2IPinteractorBRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
12 UBE2E3parental proteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
13 UFM1interactorUfm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
14 USP11interactorRibosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
15 VGLL4parental proteinVg_Tdu (PF07545, IPR011520): Vestigial/Tondu family
VGLL4 (PF15245, IPR028184): Transcription cofactor vestigial-like protein 4

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