Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BG566103 is the fusion of parental proteins SERPINA1, LAP3 (from a repository: Sat Feb 25 21:34:23 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins19 (32.76 %)
The number (and %) of the tumor suppressors6 (10.34 %)
Total number of binary PPIs (saturation %)193 (11.68 %)
The number (and %) of affected PPIs57 (29.53 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI5.966
Assortativity coefficient-0.2761
The network average Clustering coefficient0.572
The number (and %) of a zero Clustering coefficients10 (17.24 %)
The number (and %) of a zero Betweenness Centrality22 (37.93 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SERPINA1,LAP3 All fusions
: BG566103;
Proteins found in more fusions APP (see 4 fusions); ECHS1 (see 1 fusions); OS9 (see 2 fusions); SMAD4 (see 2 fusions); PRDX1 (see 1 fusions); VCP (see 4 fusions); SDC2 (see 2 fusions); TKT (see 5 fusions); TP53 (see 3 fusions); U2AF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BG566103chimera570.0732519.533Peptidase_M17_N (PF02789, IPR008283): Cytosol aminopeptidase family, N-terminal domain
Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
2 AARSD1interactor60.9330.400tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3 AGFG1interactor70.5249.333ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
4 ALADoncoprotein31.0000ALAD (PF00490, IPR001731, SM01004): Delta-aminolevulinic acid dehydratase
5 ALDH2oncoprotein40.5002.000Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
6 APPprotein found in more fusions140.19260.500APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ARPC2interactor90.61110.700P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
8 ATP5C1interactor60.4675.083ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
9 CANXinteractor50.9000.333Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
10 DDA1interactor21.0000DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
11 DDX19Binteractor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
12 DERL1interactor50.6671.667DER1 (PF04511, IPR007599): Der1-like family
13 DERL2interactor50.7002.167DER1 (PF04511, IPR007599): Der1-like family
14 ECHS1protein found in more fusions50.5002.500ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
15 ELANEinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
16 ERLEC1interactor40.8330.500PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
17 FBXO2interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
18 FN1oncoprotein150.21969.267fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
19 FUBP1oncoprotein90.50014.167DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
20 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
21 GSDMBinteractor21.0000Gasdermin (PF04598, IPR007677): Gasdermin family
22 HSPA5oncoprotein130.36433.900HSP70 (PF00012, IPR013126): Hsp70 protein
23 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
24 KLK3interactor31.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
25 LAMTOR5interactor31.0000LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
26 LIG4interactor100APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
27 MIFoncoprotein50.6671.167MIF (PF01187, IPR001398): Macrophage migration inhibitory factor (MIF)
28 MIS12interactor100DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
29 NDUFS5interactor100Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
30 NIF3L1interactor90.7503.967NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
31 NTRK1oncoprotein170.25072.833I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32 OGTinteractor50.5005.000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
33 OS9protein found in more fusions60.8001.000DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
34 PLK2suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
35 PRDX1oncoprotein70.7331.500AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
36 PRDX2interactor60.6003.817AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
37 PRTN3interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
38 RAB7Asuppressor50.9000.250Ras (PF00071, IPR001806, SM00173): Ras family
39 RAP2Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
40 RAPGEF2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
41 RBM39oncoprotein60.6002.900RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
42 RCHY1suppressor41.0000C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
43 RNF2interactor100.47213.467zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
44 SDC2protein found in more fusions31.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
45 SH3GL1oncoprotein80.8571.300BAR (PF03114, IPR004148, SM00721): BAR domain
PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
46 SH3GLB1suppressor90.6796.400BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
47 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
48 SSR1interactor40.8330.500TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
49 TAB1interactor30.6671.000PP2C (PF00481, IPR001932): Protein phosphatase 2C
50 TKTprotein found in more fusions80.6674.067Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
51 TP53suppressor90.42912.567DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
52 TPRKBinteractor60.8671.000CGI-121 (PF08617, IPR013926): Kinase binding protein CGI-121
53 U2AF2protein found in more fusions130.43922.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
54 UBA5interactor50.5002.000Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
55 VARSinteractor30.6670.250Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
56 VCPprotein found in more fusions170.29270.633AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
57 ZCCHC17interactor21.0000S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
58 ZNF558interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CA8interactorCarb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
2 ISG15suppressorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
3 LAP3parental proteinPeptidase_M17 (PF00883, IPR000819): Cytosol aminopeptidase family, catalytic domain
Peptidase_M17_N (PF02789, IPR008283): Cytosol aminopeptidase family, N-terminal domain
PAW (PF04721, IPR006588, SM00613): PNGase C-terminal domain, mannose-binding module PAW
4 SERPINA1parental proteinSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
5 VKORC1interactorVKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

B a c k    t o    T o p ⇑