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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BG566103 is the fusion of parental proteins SERPINA1, LAP3 (from a repository: Sat Feb 25 21:34:23 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins19 (32.76 %)
The number (and %) of the tumor suppressors6 (10.34 %)
Total number of binary PPIs (saturation %)193 (11.68 %)
The number (and %) of affected PPIs57 (29.53 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI5.966
Assortativity coefficient-0.2761
The network average Clustering coefficient0.572
The number (and %) of a zero Clustering coefficients10 (17.24 %)
The number (and %) of a zero Betweenness Centrality22 (37.93 %)


List of the fusions

PPI for parental proteins: SERPINA1,LAP3 All fusions
: BG566103;
Proteins found in more fusions APP (see 4 fusions); ECHS1 (see 1 fusions); OS9 (see 2 fusions); SMAD4 (see 2 fusions); PRDX1 (see 1 fusions); VCP (see 4 fusions); SDC2 (see 2 fusions); TKT (see 5 fusions); TP53 (see 3 fusions); U2AF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BG566103chimera570.0732519.533Peptidase_M17_N (PF02789, IPR008283): Cytosol aminopeptidase family, N-terminal domain
Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
2 AARSD1interactor60.9330.400tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3 AGFG1interactor70.5249.333ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
4 ALADoncoprotein31.0000ALAD (PF00490, IPR001731, SM01004): Delta-aminolevulinic acid dehydratase
5 ALDH2oncoprotein40.5002.000Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
6 APPprotein found in more fusions140.19260.500APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ARPC2interactor90.61110.700P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
8 ATP5C1interactor60.4675.083ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
9 CANXinteractor50.9000.333Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
10 DDA1interactor21.0000DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
11 DDX19Binteractor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
12 DERL1interactor50.6671.667DER1 (PF04511, IPR007599): Der1-like family
13 DERL2interactor50.7002.167DER1 (PF04511, IPR007599): Der1-like family
14 ECHS1protein found in more fusions50.5002.500ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
15 ELANEinteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
16 ERLEC1interactor40.8330.500PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
17 FBXO2interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
18 FN1oncoprotein150.21969.267fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
19 FUBP1oncoprotein90.50014.167DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
20 GDPD1interactor100GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
21 GSDMBinteractor21.0000Gasdermin (PF04598, IPR007677): Gasdermin family
22 HSPA5oncoprotein130.36433.900HSP70 (PF00012, IPR013126): Hsp70 protein
23 ICE2interactor100NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
24 KLK3interactor31.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
25 LAMTOR5interactor31.0000LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
26 LIG4interactor100APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
27 MIFoncoprotein50.6671.167MIF (PF01187, IPR001398): Macrophage migration inhibitory factor (MIF)
28 MIS12interactor100DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
29 NDUFS5interactor100Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
30 NIF3L1interactor90.7503.967NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
31 NTRK1oncoprotein170.25072.833I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
32 OGTinteractor50.5005.000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
33 OS9protein found in more fusions60.8001.000DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
34 PLK2suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
35 PRDX1oncoprotein70.7331.500AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
36 PRDX2interactor60.6003.817AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
37 PRTN3interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
38 RAB7Asuppressor50.9000.250Ras (PF00071, IPR001806, SM00173): Ras family
39 RAP2Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
40 RAPGEF2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
41 RBM39oncoprotein60.6002.900RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
42 RCHY1suppressor41.0000C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
43 RNF2interactor100.47213.467zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
44 SDC2protein found in more fusions31.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
45 SH3GL1oncoprotein80.8571.300BAR (PF03114, IPR004148, SM00721): BAR domain
PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
46 SH3GLB1suppressor90.6796.400BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
47 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
48 SSR1interactor40.8330.500TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
49 TAB1interactor30.6671.000PP2C (PF00481, IPR001932): Protein phosphatase 2C
50 TKTprotein found in more fusions80.6674.067Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
51 TP53suppressor90.42912.567DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
52 TPRKBinteractor60.8671.000CGI-121 (PF08617, IPR013926): Kinase binding protein CGI-121
53 U2AF2protein found in more fusions130.43922.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
54 UBA5interactor50.5002.000Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
55 VARSinteractor30.6670.250Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
56 VCPprotein found in more fusions170.29270.633AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
57 ZCCHC17interactor21.0000S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
58 ZNF558interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CA8interactorCarb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
2 ISG15suppressorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
3 LAP3parental proteinPeptidase_M17 (PF00883, IPR000819): Cytosol aminopeptidase family, catalytic domain
Peptidase_M17_N (PF02789, IPR008283): Cytosol aminopeptidase family, N-terminal domain
PAW (PF04721, IPR006588, SM00613): PNGase C-terminal domain, mannose-binding module PAW
4 SERPINA1parental proteinSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
5 VKORC1interactorVKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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