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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BG220754 is the fusion of parental proteins PHF14, CACNA2D1 (from a repository: Mon Nov 14 21:24:39 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins3 (13.04 %)
The number (and %) of the tumor suppressors2 (8.70 %)
Total number of binary PPIs (saturation %)28 (11.07 %)
The number (and %) of affected PPIs22 (78.57 %)
The number of possible different fusions1
PPI diameter2
PPI radius1
The average degree of PPI2.174
Assortativity coefficient-0.5481
The network average Clustering coefficient0.203
The number (and %) of a zero Clustering coefficients17 (73.91 %)
The number (and %) of a zero Betweenness Centrality21 (91.30 %)


List of the fusions

PPI for parental proteins: PHF14,CACNA2D1 All fusions
: BG220754;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BG220754chimera220.013455.000dCache_1 (PF02743, IPR004010): Cache domain
VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWA_N (PF08399, IPR013608): VWA N-terminal
2 ABCE1interactor31.0000ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 BTNL8interactor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Ig_3 (PF13927): Immunoglobulin domain
4 CCDC8interactor40.6671.000Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
5 CNOT2interactor100NOT2_3_5 (PF04153, IPR007282): NOT2 / NOT3 / NOT5 family
6 DNAAF2interactor100Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
7 ERLIN2interactor100Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
8 GLT8D2interactor100Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
9 HNRNPUinteractor21.0000CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
10 ISLRinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
11 ITM2Binteractor100BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SpoVG (PF04026, IPR007170): SpoVG
12 LMAN2interactor21.0000Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Tad (PF13400, IPR028087): Putative Flp pilus-assembly TadE/G-like
13 MYH7Binteractor100Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
14 NDUFS4interactor100ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
15 PON2interactor100Arylesterase (PF01731, IPR002640): Arylesterase
16 PTCH1suppressor100Patched (PF02460, IPR003392): Patched family
17 PTPRKsuppressor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
18 RAB11Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
19 STT3Binteractor100STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
20 SUSD4interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
21 TAZinteractor100Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
22 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
23 USP7oncoprotein31.0000MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CACNA2D1parental proteindCache_1 (PF02743, IPR004010): Cache domain
VGCC_alpha2 (PF08473, IPR013680): Neuronal voltage-dependent calcium channel alpha 2acd
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWA_N (PF08399, IPR013608): VWA N-terminal
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
2 CDK2AP1suppressorCDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
3 CEP170P1interactorNA
4 DAXXoncoproteinDaxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
5 H2AFYinteractorDUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Macro (PF01661, IPR002589, SM00506): Macro domain
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
6 HDAC1suppressorFSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
7 HIST1H2BAinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
8 HMG20AinteractorDUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
MlaC (PF05494, IPR008869): MlaC protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
9 IFI16suppressorHIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
10 KAT6AoncoproteinBUD22 (PF09073, IPR015158): BUD22
MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
PHD (PF00628, IPR019787, SM00249): PHD-finger
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
zf-met (PF12874): Zinc-finger of C2H2 type
11 MOV10interactorAAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
12 NLRP3oncoproteinNACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
FISNA (PF14484, IPR029495): Fish-specific NACHT associated domain
13 PCBD2interactorPterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
14 PHF14parental proteinAtrophin-1 (PF03154, IPR002951): Atrophin-1 family
BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
C1_2 (PF03107, IPR004146): C1 domain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
LicD (PF04991, IPR007074): LicD family
PHD (PF00628, IPR019787, SM00249): PHD-finger
Rrp15p (PF07890, IPR012459): Rrp15p
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
15 TCF20interactortRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
16 TM9SF4interactorEMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)

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