1 |
BG178591 | chimera | 34 | 0.176 | 645.337 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain RGS12_us1 (PF16613): Unstructured region of RGS12 |
2 |
ABL1 | oncoprotein | 21 | 0.358 | 83.115 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
3 |
BAG5 | interactor | 1 | 0 | 0 | BAG (PF02179, IPR003103, SM00264): BAG domain PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region RRF (PF01765, IPR023584): Ribosome recycling factor |
4 |
C15orf48 | interactor | 1 | 0 | 0 | B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit |
5 |
CAT | suppressor | 4 | 1.000 | 0 | Catalase (PF00199, IPR011614, SM01060): Catalase Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive |
6 |
CDC37 | protein found in more fusions | 6 | 0.800 | 0.619 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
7 |
CRK | oncoprotein | 10 | 0.711 | 6.599 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
8 |
DOK1 | suppressor | 10 | 0.722 | 3.229 | IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
9 |
EGFR | oncoprotein | 21 | 0.416 | 58.581 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
10 |
EPHB2 | suppressor | 4 | 1.000 | 0 | EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
11 |
ERBB2 | oncoprotein | 15 | 0.527 | 19.752 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
12 |
ERBB3 | oncoprotein | 15 | 0.505 | 21.635 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
13 |
ERBB4 | suppressor | 10 | 0.694 | 4.028 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
14 |
FBXO38 | interactor | 1 | 0 | 0 | Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain F-box (PF00646, IPR001810, SM00256): F-box domain |
15 |
GPX1 | oncoprotein | 2 | 1.000 | 0 | GSHPx (PF00255, IPR000889): Glutathione peroxidase |
16 |
GRB2 | oncoprotein | 14 | 0.590 | 16.290 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
17 |
HCK | oncoprotein | 9 | 0.528 | 9.380 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
18 |
HRAS | oncoprotein | 2 | 1.000 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family |
19 |
JAK1 | oncoprotein | 9 | 0.714 | 3.041 | FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
20 |
MAP3K10 | interactor | 2 | 0 | 0 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552) SH3_9 (PF14604, IPR001452): Variant SH3 domain |
21 |
MDM2 | oncoprotein | 10 | 0.500 | 7.789 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
22 |
MED28 | interactor | 5 | 0.500 | 1.452 | cwf21 (PF08312, IPR013170, SM01115): cwf21 domain Med28 (PF11594, IPR021640): Mediator complex subunit 28 |
23 |
NCK1 | oncoprotein | 9 | 0.722 | 3.118 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
24 |
NCK2 | interactor | 8 | 0.714 | 2.344 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
25 |
NEDD4 | suppressor | 8 | 0.762 | 1.578 | Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
26 |
NEDD4L | suppressor | 5 | 0.667 | 1.167 | WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
27 |
NTRK1 | oncoprotein | 12 | 0.455 | 18.167 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
28 |
OIP5 | interactor | 1 | 0 | 0 | Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly |
29 |
PIK3R3 | interactor | 9 | 0.722 | 3.610 | SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
30 |
PSMA7 | protein found in more fusions | 6 | 0.800 | 0.622 | Proteasome (PF00227, IPR001353): Proteasome subunit Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
31 |
RIN1 | interactor | 5 | 0.700 | 3.000 | RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain |
32 |
SORBS2 | oncoprotein | 6 | 0.700 | 1.175 | Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
33 |
STAT3 | suppressor | 9 | 0.571 | 8.371 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
34 |
TPD52L1 | interactor | 2 | 0 | 0 | TPD52 (PF04201, IPR007327): Tumour protein D52 family |
35 |
TRIP10 | interactor | 3 | 1.000 | 0 | Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1 |