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Fusion ID: Protein names:	BG178591
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Visualization interactions

Cytoscape Web for: BG178591 is the fusion of parental proteins ABL2 (from a repository: Tue Dec 27 23:15:13 2016)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	35
The number (and %) of the onco-proteins	17 (48.57 %)
The number (and %) of the tumor suppressors	7 (20.00 %)
Total number of binary PPIs (saturation %)	156 (26.22 %)
The number (and %) of affected PPIs	34 (21.79 %)
The number of possible different fusions	12
PPI diameter	2
PPI radius	1
The average degree of PPI	7.600
Assortativity coefficient	-0.2408
The network average Clustering coefficient	0.559
The number (and %) of a zero Clustering coefficients	6 (17.14 %)
The number (and %) of a zero Betweenness Centrality	11 (31.43 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: ABL2	All fusions : BG178591;
Proteins found in more fusions	ERBB3 (see 2 fusions); STAT3 (see 2 fusions); JAK1 (see 1 fusions); NEDD4L (see 3 fusions); GRB2 (see 1 fusions); CDC37 (see 2 fusions); EGFR (see 2 fusions); NEDD4 (see 1 fusions); SORBS2 (see 4 fusions); PSMA7 (see 2 fusions); EPHB2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	BG178591	chimera	34	0.176	645.337	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain RGS12_us1 (PF16613): Unstructured region of RGS12
2	ABL1	oncoprotein	21	0.358	83.115	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	BAG5	interactor	1	0	0	BAG (PF02179, IPR003103, SM00264): BAG domain PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region RRF (PF01765, IPR023584): Ribosome recycling factor
4	C15orf48	interactor	1	0	0	B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
5	CAT	suppressor	4	1.000	0	Catalase (PF00199, IPR011614, SM01060): Catalase Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
6	CDC37	protein found in more fusions	6	0.800	0.619	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
7	CRK	oncoprotein	10	0.711	6.599	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
8	DOK1	suppressor	10	0.722	3.229	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
9	EGFR	oncoprotein	21	0.416	58.581	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
10	EPHB2	suppressor	4	1.000	0	EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
11	ERBB2	oncoprotein	15	0.527	19.752	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
12	ERBB3	oncoprotein	15	0.505	21.635	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
13	ERBB4	suppressor	10	0.694	4.028	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14	FBXO38	interactor	1	0	0	Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain F-box (PF00646, IPR001810, SM00256): F-box domain
15	GPX1	oncoprotein	2	1.000	0	GSHPx (PF00255, IPR000889): Glutathione peroxidase
16	GRB2	oncoprotein	14	0.590	16.290	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
17	HCK	oncoprotein	9	0.528	9.380	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
18	HRAS	oncoprotein	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
19	JAK1	oncoprotein	9	0.714	3.041	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
20	MAP3K10	interactor	2	0	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552) SH3_9 (PF14604, IPR001452): Variant SH3 domain
21	MDM2	oncoprotein	10	0.500	7.789	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
22	MED28	interactor	5	0.500	1.452	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain Med28 (PF11594, IPR021640): Mediator complex subunit 28
23	NCK1	oncoprotein	9	0.722	3.118	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
24	NCK2	interactor	8	0.714	2.344	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
25	NEDD4	suppressor	8	0.762	1.578	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
26	NEDD4L	suppressor	5	0.667	1.167	WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
27	NTRK1	oncoprotein	12	0.455	18.167	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
28	OIP5	interactor	1	0	0	Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
29	PIK3R3	interactor	9	0.722	3.610	SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
30	PSMA7	protein found in more fusions	6	0.800	0.622	Proteasome (PF00227, IPR001353): Proteasome subunit Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
31	RIN1	interactor	5	0.700	3.000	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
32	SORBS2	oncoprotein	6	0.700	1.175	Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
33	STAT3	suppressor	9	0.571	8.371	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
34	TPD52L1	interactor	2	0	0	TPD52 (PF04201, IPR007327): Tumour protein D52 family
35	TRIP10	interactor	3	1.000	0	Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1

B a c k t o T o p ⇑

List of missing interactors