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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BG008529 is the fusion of parental proteins MDM4 (from a repository: Wed Nov 16 02:09:27 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins6 (31.58 %)
The number (and %) of the tumor suppressors9 (47.37 %)
Total number of binary PPIs (saturation %)71 (41.52 %)
The number (and %) of affected PPIs18 (25.35 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI6.211
Assortativity coefficient-0.4720
The network average Clustering coefficient0.688
The number (and %) of a zero Clustering coefficients2 (10.53 %)
The number (and %) of a zero Betweenness Centrality6 (31.58 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MDM4 All fusions
: BG008529;
Proteins found in more fusions HSP90AA1 (see 2 fusions); PPARD (see 1 fusions); EP300 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BG008529chimera180.268134.633SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
2 ABL1oncoprotein70.8671.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 C1orf111interactor100zf-C2H2_4 (PF13894): C2H2-type zinc finger
4 CDKN2Asuppressor50.9000.500Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
5 CHEK2suppressor60.8001.000FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
6 EP300oncoprotein110.48914.500Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
7 HSP90AA1oncoprotein80.5717.333HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
8 LRSAM1interactor31.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9 MDM2oncoprotein160.38145.633Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 NBNsuppressor41.0000FHA (PF00498, IPR000253, SM00240): FHA domain
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
11 PPARDoncoprotein50.8330.500zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
12 RAD50interactor50.8001.067DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
YscO (PF07321, IPR009929): Type III secretion protein YscO
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2703 (PF10865, IPR021219): Domain of unknown function (DUF2703)
DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015)
AAA_13 (PF13166, IPR026866): AAA domain
AAA_23 (PF13476): AAA domain
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
13 RB1suppressor70.8101.800RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
14 RFWD2suppressor41.0000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
15 RNF115interactor200Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zinc_ribbon_9 (PF14369): zinc-ribbon
16 SMARCA2suppressor31.0000DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
17 TP53suppressor120.52715.133DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
18 TP63suppressor60.9000.500Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
19 TP73suppressor70.9330.400P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 APPinteractorAPP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
2 BCL2oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
3 CAPN7interactorCalpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
4 CD160interactorIg_3 (PF13927): Immunoglobulin domain
5 CDKN1AsuppressorCDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
6 CHEK1suppressorPkinase (PF00069, IPR000719): Protein kinase domain
7 CSNK1A1suppressorPkinase (PF00069, IPR000719): Protein kinase domain
8 E2F1suppressorCellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
9 MAGEA1interactorMAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
10 MAGEB1interactorMAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
11 MDM4parental proteinzf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
12 MKRN3oncoproteinzf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-3CxxC_2 (PF17180): Zinc-binding domain
13 MNAT1oncoproteinMAT1 (PF06391, IPR015877): CDK-activating kinase assembly factor MAT1
Mu-like_Com (PF10122, IPR019294): Mu-like prophage protein Com
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
14 MRE11AoncoproteinAPG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
15 PPP1CAsuppressorMetallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
16 PPP1CBinteractorMetallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
17 PPP1CConcoproteinMetallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
18 PRKAA1suppressorPkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
19 PSMC5interactorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
20 PSMD2oncoproteinPC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
21 RAD54BinteractorSNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
HDA2-3 (PF11496, IPR021006): Class II histone deacetylase complex subunits 2 and 3
22 RCHY1suppressorC1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
23 RN5S1@interactorNA
24 RPL37interactorRibosomal_L37e (PF01907, IPR001569): Ribosomal protein L37e
25 RPS15interactorRibosomal_S19 (PF00203, IPR002222): Ribosomal protein S19
Prok_Ub (PF14454, IPR032866): Prokaryotic Ubiquitin
26 RPS20interactorRibosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
27 SFNsuppressor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
28 SMAD3oncoproteinMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
29 SMAD4suppressorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
30 TRIM46interactorFlgN (PF05130, IPR007809): FlgN protein
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
31 TRIM55interactorHerpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
32 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33 UBE2D1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
34 UBE2D2oncoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 UBE2D3interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
36 USP2interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
37 USP22interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUF2769 (PF10967, IPR020075): Protein of unknown function (DUF2769)
38 USP7oncoproteinMATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
39 YWHABinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
40 YWHAEoncoprotein14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
41 YWHAGinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
42 YWHAHinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
43 YWHAQinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
44 YWHAZinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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