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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF948432 is the fusion of parental proteins SYN1 (from a repository: Sun Nov 13 19:34:25 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins10 (29.41 %)
The number (and %) of the tumor suppressors6 (17.65 %)
Total number of binary PPIs (saturation %)80 (14.26 %)
The number (and %) of affected PPIs33 (41.25 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.882
Assortativity coefficient-0.4660
The network average Clustering coefficient0.471
The number (and %) of a zero Clustering coefficients10 (29.41 %)
The number (and %) of a zero Betweenness Centrality18 (52.94 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SYN1 All fusions
: BF948432;
Proteins found in more fusions ITSN2 (see 1 fusions); KAT5 (see 3 fusions); PIK3R1 (see 1 fusions); GRB2 (see 1 fusions); DDX5 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF948432chimera330.062926.167Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain
2 AMPHoncoprotein60.4007.833BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
3 ANTXR1interactor100Ant_C (PF05586, IPR008399): Anthrax receptor C-terminus region
Anth_Ig (PF05587, IPR008400): Anthrax receptor extracellular domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
4 ARMC1interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HMA (PF00403, IPR006121): Heavy-metal-associated domain
5 ATG4Ainteractor100Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
6 BIN1suppressor41.0000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
7 BLMsuppressor200BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
8 CRKoncoprotein50.7003.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9 DDX5oncoprotein60.4006.000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
10 DGCR8interactor21.0000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
WW (PF00397, IPR001202, SM00456): WW domain
11 DNAAF2interactor40.5001.667Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
12 ERGoncoprotein21.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
13 ERGIC1interactor100COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
14 ERI1interactor100RNase_T (PF00929, IPR013520): Exonuclease
SAP (PF02037, IPR003034, SM00513): SAP domain
15 GRB2oncoprotein60.7003.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
16 GTF3C2interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
17 HAX1interactor40.5001.667Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
18 ITSN2protein found in more fusions40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
19 KAT5suppressor200MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
20 LUC7L3interactor31.0000LUC7 (PF03194, IPR004882): LUC7 N_terminus
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
21 NCF1interactor200p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
22 NOS1interactor21.0000FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
23 NOS1APinteractor40.5002.500Phage_GPO (PF05929, IPR009228): Phage capsid scaffolding protein (GPO) serine peptidase
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
24 NUFIP1interactor40.6671.500NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
25 PARK2suppressor60.4005.667IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
26 PIK3R1oncoprotein51.0000RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
27 PSMD2oncoprotein21.0000PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
28 RB1CC1suppressor100Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
29 SNCAinteractor90.25018.833Synuclein (PF01387, IPR001058): Synuclein
30 SRConcoprotein60.7003.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31 SRRTinteractor30.6670.667ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546)
DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
32 SYN2interactor60.4004.833LpxD (PF04613, IPR020573): UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD
SPX (PF03105, IPR004331): SPX domain
Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain
Synapsin_N (PF10581, IPR019736): Synapsin N-terminal
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain
33 VIMsuppressor50.5002.667Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
34 VPS54interactor100Vps54 (PF07928, IPR012501): Vps54-like protein
Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
SBP_bac_6 (PF13343): Bacterial extracellular solute-binding protein
YqzH (PF14164, IPR025546): YqzH-like protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 DGUOKinteractordNK (PF01712, IPR002624): Deoxynucleoside kinase
2 SAP130interactorSAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
3 SYN1parental proteinSynapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain
Synapsin_N (PF10581, IPR019736): Synapsin N-terminal
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain

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