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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF918420 is the fusion of parental proteins ZNF276, DHCR24 (from a repository: Mon Sep 16 05:16:09 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins6 (50.00 %)
The number (and %) of the tumor suppressors1 (8.33 %)
Total number of binary PPIs (saturation %)22 (33.33 %)
The number (and %) of affected PPIs11 (50.00 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI2.500
Assortativity coefficient-0.7499
The network average Clustering coefficient0.373
The number (and %) of a zero Clustering coefficients6 (50.00 %)
The number (and %) of a zero Betweenness Centrality10 (83.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: FANCA,DHCR24 All fusions
: BF918420;
Proteins found in more fusions TP53 (see 3 fusions); IKBKB (see 2 fusions); EGFR (see 2 fusions); ATXN1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF918420chimera110.07396.000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-AD (PF07776, IPR012934, SM00868): Zinc-finger associated domain (zf-AD)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
RBR (PF17208): RNA binding Region
2 ATXN1protein found in more fusions200AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
3 EGFRoncoprotein31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
4 GCC1interactor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
GRIP (PF01465, IPR000237, SM00755): GRIP domain
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
FAM184 (PF15665): Family with sequence similarity 184, A and B
5 HRASoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
6 IKBKBprotein found in more fusions31.0000FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
7 LUZP1interactor100Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
TMA7 (PF09072, IPR015157): Translation machinery associated TMA7
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
8 NANOGinteractor200Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
9 POU5F1oncoprotein200Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
10 TP53suppressor60.4006.000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
11 UBL4Ainteractor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
12 ZBTB8Ainteractor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACTA2interactorActin (PF00022, IPR004000, SM00268): Actin
2 ATP12AinteractorCation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
3 CISD3interactorzf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
4 CKAP5interactorHEAT (PF02985, IPR000357): HEAT repeat
PAS_6 (PF08348, IPR013559): YheO-like PAS domain
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
5 COQ9interactorCOQ9 (PF08511, IPR013718): COQ9
6 DHCR24parental proteinFAD_binding_4 (PF01565, IPR006094): FAD binding domain
7 ERAP1interactorPeptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
8 FUNDC2interactorFUN14 (PF04930, IPR007014): FUN14 family
9 GBAinteractorGlyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain
Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain
10 NDUFA4interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
11 REEP5interactorPhage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
12 SNCAinteractorSynuclein (PF01387, IPR001058): Synuclein
13 ZNF276parental proteinIBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-AD (PF07776, IPR012934, SM00868): Zinc-finger associated domain (zf-AD)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
RBR (PF17208): RNA binding Region

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