Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BF917173 is the fusion of parental proteins KIAA1217, PDE4D (from a repository: Tue Jan 10 19:41:25 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins12 (46.15 %)
The number (and %) of the tumor suppressors3 (11.54 %)
Total number of binary PPIs (saturation %)64 (19.69 %)
The number (and %) of affected PPIs25 (39.06 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI3.846
Assortativity coefficient-0.3796
The network average Clustering coefficient0.620
The number (and %) of a zero Clustering coefficients6 (23.08 %)
The number (and %) of a zero Betweenness Centrality18 (69.23 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PDE4D,KIAA1217 All fusions
: BF917173;
Proteins found in more fusions FYN (see 1 fusions); LYN (see 2 fusions); APP (see 4 fusions); ZDHHC17 (see 2 fusions); RACK1 (see 3 fusions); GRB2 (see 1 fusions); PAFAH1B1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF917173chimera250.083502.667Herpes_UL49_5 (PF05702, IPR008647): Herpesvirus UL49.5 envelope/tegument protein
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
2 ABL1oncoprotein60.6002.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 AKAP6interactor100IPK (PF03770, IPR005522): Inositol polyphosphate kinase
Spectrin (PF00435, IPR002017): Spectrin repeat
4 APPprotein found in more fusions40.6671.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARRB1interactor60.6673.000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ARRB2interactor60.6673.000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 BIN1suppressor31.0000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
8 FYNoncoprotein41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9 GRB2oncoprotein41.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
10 HDGFRP2interactor31.0000DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
PWWP (PF00855, IPR000313, SM00293): PWWP domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
LEDGF (PF11467, IPR021567): Lens epithelium-derived growth factor (LEDGF)
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
ACTH_assoc (PF16102, IPR032246): ACTH-associated domain
11 ITSN1interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
12 LYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13 MAGEA6interactor21.0000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
14 MDM2oncoprotein70.6005.000Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
15 NCK2interactor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
16 PAFAH1B1suppressor200LisH (PF08513, IPR013720, SM00667): LisH
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
17 PDE4DIPoncoprotein21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
IncA (PF04156, IPR007285): IncA protein
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
FAM76 (PF16046, IPR032017): FAM76 protein
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
18 PIAS4interactor21.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
19 PPP3CBinteractor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PRIMA1 (PF16101): Proline-rich membrane anchor 1
20 PPP3R1interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
21 RACK1suppressor41.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
22 SPTAN1oncoprotein50.5004.000EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
23 SRConcoprotein110.33328.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
24 TRAF1oncoprotein31.0000HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
25 ZBTB1interactor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
26 ZDHHC17protein found in more fusions200zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ABI2suppressorAbi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
2 CDK2suppressorKdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
3 CNTROBinteractorDUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
FadA (PF09403, IPR018543): Adhesion protein FadA
Flavodoxin_5 (PF12724, IPR026816): Flavodoxin domain
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
4 COILinteractorCDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
5 CSNK1A1suppressorPkinase (PF00069, IPR000719): Protein kinase domain
6 EXOSC5interactorRNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
7 FHL2oncoproteinLIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
8 FXR2interactorAgenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
9 GCC1interactorDUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
GRIP (PF01465, IPR000237, SM00755): GRIP domain
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
FAM184 (PF15665): Family with sequence similarity 184, A and B
10 GOLGA2interactorATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
11 GOLGA8EPinteractorNA
12 GOLGA8FinteractorT3SS_needle_E (PF08988, IPR012671): Type III secretion system, cytoplasmic E component of needle
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlxA (PF14282, IPR025577): FlxA-like protein
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
13 GSK3BsuppressorPkinase (PF00069, IPR000719): Protein kinase domain
14 HNRNPLLinteractorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 HSBP1interactorHSBP1 (PF06825, IPR009643): Heat shock factor binding protein 1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
16 ITPKBinteractorIPK (PF03770, IPR005522): Inositol polyphosphate kinase
17 KIAA1217parental proteinAIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
18 KRT15interactorFilament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
19 MAPK1oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
20 MICU2interactor23S_rRNA_IVP (PF05635, IPR012657): 23S rRNA-intervening sequence protein
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
21 NARSinteractortRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
22 NINLinteractorPD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
TBCA (PF02970, IPR004226): Tubulin binding cofactor A
DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389)
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
23 PDE4Dparental proteinNa_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
24 PFKFB2interactor6PF2K (PF01591, IPR013079): 6-phosphofructo-2-kinase
His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
25 PIK3R1oncoproteinRhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
26 PPP3CAinteractorMetallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
27 PRKACAinteractorPkinase (PF00069, IPR000719): Protein kinase domain
28 SEC16AinteractorAPC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
29 SHMT2interactorSHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
30 SIAH1suppressorSina (PF03145, IPR018121): Seven in absentia protein family
31 SORBS3interactorSorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
32 TEX11interactorSPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat
33 TRIM23interactorArf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
34 VPS52interactorVps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
35 XPO1interactorCRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑