Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BF916410 is the fusion of parental proteins PDXK, RAD9A (from a repository: Tue Jun 25 23:46:14 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins8 (33.33 %)
The number (and %) of the tumor suppressors2 (8.33 %)
Total number of binary PPIs (saturation %)66 (23.91 %)
The number (and %) of affected PPIs23 (34.85 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.417
Assortativity coefficient-0.4409
The network average Clustering coefficient0.521
The number (and %) of a zero Clustering coefficients6 (25.00 %)
The number (and %) of a zero Betweenness Centrality10 (41.67 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: RAD9A,PDXK All fusions
: BF916410;
Proteins found in more fusions EZR (see 2 fusions); COPS5 (see 1 fusions); ITPA (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); G6PD (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF916410chimera230.119395.700Phos_pyr_kin (PF08543, IPR013749): Phosphomethylpyrimidine kinase
2 ABATinteractor100Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
3 BARD1suppressor40.6670.400BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
4 CAND1interactor80.8101.700Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
5 COPS5protein found in more fusions90.6437.700JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
6 CUL1suppressor80.7145.400Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
7 CUL3protein found in more fusions80.8101.700Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
8 EIF4Eoncoprotein100IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
9 ELAVL1oncoprotein90.46414.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 EZRprotein found in more fusions40.6671.000DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
11 FEM1Binteractor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
12 G6PDprotein found in more fusions200G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
13 HIBADHinteractor50.5003.000NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
NAD_binding_11 (PF14833, IPR029154): NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
14 HYIinteractor100AP_endonuc_2 (PF01261, IPR013022): Xylose isomerase-like TIM barrel
15 ITPAprotein found in more fusions40.6670.400Ham1p_like (PF01725, IPR002637): Ham1 family
16 MDH1interactor21.0000Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
17 MOV10interactor60.5335.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
18 NXF1interactor80.5718.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
19 OATinteractor30.6671.000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
20 OGTinteractor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
21 RABIFinteractor100Mss4 (PF04421, IPR007515): Mss4 protein
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
22 SNX2interactor100PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
23 SOD1interactor40.6671.000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
24 TPI1interactor31.0000TIM (PF00121, IPR000652): Triosephosphate isomerase

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ABL1oncoproteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
2 ARoncoproteinAndrogen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
3 ATRsuppressorFAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
THP2 (PF09432, IPR018557): Tho complex subunit THP2
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT
4 ATRXoncoproteinDDHD (PF02862, IPR004177, SM01127): DDHD domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Zip (PF02535, IPR003689): ZIP Zinc transporter
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
FAM176 (PF14851): FAM176 family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
5 BCL2oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
6 BCL2L1oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
7 CLSPNinteractorCwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein
Presenilin (PF01080, IPR001108): Presenilin
PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit
XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
8 DNAJC7interactorDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
9 DNMT1suppressorBAH (PF01426, IPR001025, SM00439): BAH domain
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
DNMT1-RFD (PF12047, IPR022702): Cytosine specific DNA methyltransferase replication foci domain
10 FEN1oncoprotein5_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold
XPG_I (PF00867, IPR006086, SM00484): XPG I-region
XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
11 HDAC1suppressorFSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
12 HUS1oncoproteinHus1 (PF04005, IPR007150): Hus1-like protein
13 HUS1BinteractorHus1 (PF04005, IPR007150): Hus1-like protein
14 MSH2suppressorMutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
15 MSH3oncoproteinMutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
16 MSH6oncoproteinMutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
PWWP (PF00855, IPR000313, SM00293): PWWP domain
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
UPF0524 (PF15823, IPR029670): UPF0524 of C3orf70
17 NR3C1interactorGCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
18 PCNAoncoproteinPCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
19 PDXKparental proteinPhos_pyr_kin (PF08543, IPR013749): Phosphomethylpyrimidine kinase
Staphylokinase (PF02821, IPR004093): Staphylokinase/Streptokinase family
20 RAD1interactorPro_3_hydrox_C (PF05373, IPR008035): L-proline 3-hydroxylase, C-terminal
Rad1 (PF02144, IPR003021): Repair protein Rad1/Rec1/Rad17
21 RAD17interactorMvb12 (PF09452, IPR019014): ESCRT-I subunit Mvb12
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
22 RAD9Aparental proteinRad9 (PF04139, IPR007268): Rad9
23 RHNO1interactorRHINO (PF15319, IPR029293): RAD9, RAD1, HUS1-interacting nuclear orphan protein
24 RPA1suppressorRep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
25 RPA2oncoproteinRPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
26 SETMARinteractorPre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
Transposase_1 (PF01359, IPR001888): Transposase (partial DDE domain)
HTH_Tnp_Tc3_2 (PF01498, IPR002492): Transposase
DDE_3 (PF13358): DDE superfamily endonuclease
HTH_32 (PF13565): Homeodomain-like domain
27 SF3B3interactorCPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
28 TOPBP1interactorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
29 TWNKinteractorT2SSE (PF00437, IPR001482): Type II/IV secretion system protein
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_25 (PF13481): AAA domain
30 YWHAQinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k    t o    T o p ⇑