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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF912932 is the fusion of parental proteins CHI3L1, THBS3 (from a repository: Tue Feb 6 02:08:52 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins6 (9.38 %)
The number (and %) of the tumor suppressors4 (6.25 %)
Total number of binary PPIs (saturation %)76 (3.77 %)
The number (and %) of affected PPIs63 (82.89 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.250
Assortativity coefficient-0.6377
The network average Clustering coefficient0.154
The number (and %) of a zero Clustering coefficients52 (81.25 %)
The number (and %) of a zero Betweenness Centrality60 (93.75 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions
PPI for parental proteins: THBS3,CHI3L1 All fusions
: BF912932;
Proteins found in more fusions SH3BP4 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam, InterPro, SMART): description
1 BF912932chimera640.0053883.000TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
2 APBB1interactor200PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
3 ARHGEF1interactor200RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Syntaxin_2 (PF14523): Syntaxin-like protein
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
4 ASCC3interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
PhoH (PF02562, IPR003714): PhoH-like protein
Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
5 BBS2interactor100BBS2_N (PF14781, IPR029430): Ciliary BBSome complex subunit 2, N-terminal
BBS2_C (PF14782, IPR029333): Ciliary BBSome complex subunit 2, C-terminal
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
6 BBS7interactor100ZapB (PF06005, IPR009252): Cell division protein ZapB
FlxA (PF14282, IPR025577): FlxA-like protein
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
7 BDH1interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
DUF1776 (PF08643, IPR013952): Fungal family of unknown function (DUF1776)
8 BLVRAinteractor100Biliv-reduc_cat (PF09166, IPR015249): Biliverdin reductase, catalytic
GFO_IDH_MocA (PF01408, IPR000683): Oxidoreductase family, NAD-binding Rossmann fold
9 C5orf34interactor100DUF4520 (PF15016, IPR027865): Domain of unknown function (DUF4520)
DUF4524 (PF15025, IPR027830): Domain of unknown function (DUF4524)
10 CCT7interactor30.6671.000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CCZ1interactor100DUF1712 (PF08217, IPR013176): Fungal domain of unknown function (DUF1712)
12 CORO7interactor100DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
13 CPS1interactor21.0000CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain
CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
MGS (PF02142, IPR011607, SM00851): MGS-like domain
14 CPSF3Linteractor100RMMBL (PF07521, IPR011108): Zn-dependent metallo-hydrolase RNA specificity domain
Beta-Casp (PF10996, IPR022712, SM01027): Beta-Casp domain
Lactamase_B_3 (PF13483): Beta-lactamase superfamily domain
Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
15 CWF19L1interactor100CwfJ_C_1 (PF04677, IPR006768): Protein similar to CwfJ C-terminus 1
CwfJ_C_2 (PF04676, IPR006767): Protein similar to CwfJ C-terminus 2
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
16 DDX11interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DEAD_2 (PF06733, IPR010614): DEAD_2
HBB (PF06777, IPR010643): Helical and beta-bridge domain
Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
17 DIP2Ainteractor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
18 DNM3interactor100Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
19 FANCBinteractor100DP (PF08781, IPR014889, SM01138): Transcription factor DP
20 FDXRinteractor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
21 GTPBP6interactor200GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
GTP-bdg_N (PF13167, IPR025121): GTP-binding GTPase N-terminal
GTP-bdg_M (PF16360, IPR032305): GTP-binding GTPase Middle Region
22 HPS3interactor100HPS3_N (PF14761, IPR029437): Hermansky-Pudlak syndrome 3
HPS3_Mid (PF14762, IPR028167): Hermansky-Pudlak syndrome 3, middle region
HPS3_C (PF14763, IPR029438): Hermansky-Pudlak syndrome 3, C-terminal
23 HSPD1suppressor100Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
24 IQSEC2interactor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SlyX (PF04102, IPR007236): SlyX
Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
PRIMA1 (PF16101): Proline-rich membrane anchor 1
IQ_SEC7_PH (PF16453, IPR001849): PH domain
25 LRWD1interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
26 MCM9suppressor100MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_OB (PF17207): MCM OB domain
27 METTL13interactor100Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
Methyltransf_23 (PF13489): Methyltransferase domain
28 MKS1interactor30.6671.000B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
29 MTO1interactor100GIDA (PF01134, IPR002218): Glucose inhibited division protein A
GIDA_assoc (PF13932, IPR026904): GidA associated domain
30 MTPAPinteractor100PAP_assoc (PF03828, IPR002058): Cid1 family poly A polymerase
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
tRNA_NucTransf2 (PF09249, IPR015329): tRNA nucleotidyltransferase, second domain
31 NDUFA3interactor100NADHdh_A3 (PF14987, IPR026626): NADH dehydrogenase 1 alpha subcomplex subunit 3
32 NOL11interactor100NUC205 (PF08168, IPR012584): NUC205 domain
DUF2779 (PF11074, IPR021301): Domain of unknown function(DUF2779)
33 NSUN2interactor100Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
34 PCinteractor100Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
35 PCCAinteractor100Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
SLT_beta (PF02258, IPR003189): Shiga-like toxin beta subunit
36 PDE7Ainteractor100PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
37 PEX1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
PEX-1N (PF09262, IPR015342): Peroxisome biogenesis factor 1, N-terminal
PEX-2N (PF09263, IPR015343): Peroxisome biogenesis factor 1, N-terminal
38 PEX6interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
TsaE (PF02367, IPR003442): Threonylcarbamoyl adenosine biosynthesis protein TsaE
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
39 PIK3C2Ainteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PX (PF00787, IPR001683, SM00312): PX domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
40 PKN2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
41 PLD2interactor100PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
42 PPOXinteractor100Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
43 RAD21oncoprotein40.5003.000Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
44 RAD51Csuppressor100Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
45 RFC1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
Nexin_C (PF08628, IPR013937): Sorting nexin C terminal
RFC1 (PF08519, IPR013725): Replication factor RFC1 C terminal domain
DUF2316 (PF10078, IPR018757): Uncharacterized protein conserved in bacteria (DUF2316)
46 RIC8Binteractor100Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
47 RIPK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
48 RPL23interactor21.0000Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
49 RTEL1oncoprotein100C1_2 (PF03107, IPR004146): C1 domain
DEAD_2 (PF06733, IPR010614): DEAD_2
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
DZR (PF12773, IPR025874): Double zinc ribbon
Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
CCM2_C (PF16545, IPR032375): Cerebral cavernous malformation protein, harmonin-homology
50 SH3BP4protein found in more fusions200SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
51 SMG8interactor100Smg8_Smg9 (PF10220, IPR019354): Smg8_Smg9
52 TBC1D2Binteractor21.0000IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
KRAB (PF01352, IPR001909, SM00349): KRAB box
PH (PF00169, IPR001849, SM00233): PH domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
53 THBS1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EndIII_4Fe-2S (PF10576, IPR003651): Iron-sulfur binding domain of endonuclease III
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
54 THBS4interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EF-hand_5 (PF13202, IPR002048): EF hand
55 TIGD5interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
CENP-B_N (PF04218, IPR007889): CENP-B N-terminal DNA-binding domain
DDE_1 (PF03184, IPR004875): DDE superfamily endonuclease
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
56 TOP2Aoncoprotein100DNA_gyraseB (PF00204, IPR013506): DNA gyrase B
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Toprim (PF01751, IPR006171, SM00493): Toprim domain
DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
57 TRMT44interactor100AdoMet_MTase (PF07757, IPR011671): Predicted AdoMet-dependent methyltransferase
58 TROinteractor100MAGE (PF01454, IPR002190): MAGE family
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
AP3D1 (PF06375): AP-3 complex subunit delta-1
59 TTLL5interactor100TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
60 TUBA1Aoncoprotein31.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
61 TUBA4Ainteractor31.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
62 TUBB3interactor31.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
63 TUBB8interactor100Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
64 UTP4interactor100CPSF_A (PF03178, IPR004871): CPSF A subunit region
PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PQQ_2 (PF13360, IPR002372): PQQ-like domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BREoncoproteinBRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
2 CD55oncoproteinSushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
HYLS1_C (PF15311, IPR027918): Hydrolethalus syndrome protein 1 C-terminus
3 CHI3L1parental proteinGlyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
4 MTRF1LinteractorPCRF (PF03462, IPR005139, SM00937): PCRF domain
RF-1 (PF00472, IPR000352): RF-1 domain
5 THBS3parental proteinEGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain

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