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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)67
The number (and %) of the onco-proteins26 (38.81 %)
The number (and %) of the tumor suppressors2 (2.99 %)
Total number of binary PPIs (saturation %)289 (13.07 %)
The number (and %) of affected PPIs66 (22.84 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI8.090
Assortativity coefficient-0.2550
The network average Clustering coefficient0.531
The number (and %) of a zero Clustering coefficients8 (11.94 %)
The number (and %) of a zero Betweenness Centrality15 (22.39 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ARF1 All fusions
: BF893864;
Proteins found in more fusions GRK5 (see 4 fusions); EEF1G (see 1 fusions); KDELR1 (see 2 fusions); CUL7 (see 2 fusions); HUWE1 (see 2 fusions); COPB1 (see 2 fusions); UBC (see 1 fusions); HERC1 (see 1 fusions); COPG1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF893864chimera660.0963162.252Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
Mcp5_PH (PF12814, IPR024774): Meiotic cell cortex C-terminal pleckstrin homology
2 ACADMoncoprotein80.6793.380Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
3 AHSA1interactor100.6447.352Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
4 AP1B1interactor30.6671.000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
5 AP1G1interactor40.5002.667Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
6 AP3S2interactor21.0000Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7 AP4E1interactor21.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
AP4E_app_platf (PF14807, IPR028269): Adaptin AP4 complex epsilon appendage platform
8 AP4M1interactor30.6671.000Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
9 ARF3interactor80.39314.833Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
10 ARF4interactor130.33332.140Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
11 ARF5interactor140.28646.919Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
12 ARFGAP3interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
13 ARFIP1interactor40.8330.400Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
14 ARFIP2interactor50.8330.400Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
15 ATF2oncoprotein80.5714.591bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
16 CCT3interactor150.50522.614Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17 CCT6Ainteractor110.5827.810Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 CDK2suppressor140.29535.512Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
19 CHRM3interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
GWT1 (PF06423, IPR009447): GWT1
20 COPB1protein found in more fusions80.38110.150Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform
21 COPEinteractor50.8330.500Coatomer_E (PF04733, IPR006822): Coatomer epsilon subunit
TPR_19 (PF14559): Tetratricopeptide repeat
22 COPG1protein found in more fusions50.6671.167Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain
Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
23 CUL7protein found in more fusions160.31454.410ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
24 CYTH2interactor100NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
PH (PF00169, IPR001849, SM00233): PH domain
Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
25 EEF1Gprotein found in more fusions70.6001.667EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
26 ETFAinteractor170.43443.192ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
ETF_alpha (PF00766, IPR014731): Electron transfer flavoprotein FAD-binding domain
27 FBXO6interactor100.46711.924FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
28 GGA1oncoprotein80.4768.900Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
GAT (PF03127, IPR004152): GAT domain
Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide
VHS (PF00790, IPR002014, SM00288): VHS domain
AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal
29 GGA2interactor41.0000Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
30 GGA3interactor50.8001.167Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
31 GRK5protein found in more fusions50.5002.500Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
32 HERC1protein found in more fusions31.0000Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Presenilin (PF01080, IPR001108): Presenilin
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SPRY (PF00622, IPR003877, SM00449): SPRY domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
33 HUWE1oncoprotein140.39734.910BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
34 ITGA4interactor110.57811.369FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
35 KDELR1protein found in more fusions31.0000ER_lumen_recept (PF00810, IPR000133): ER lumen protein retaining receptor
36 LDHAinteractor230.38171.037Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
37 LDHAL6Ainteractor50.7000.794Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
38 LDHAL6Binteractor60.6671.329Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
39 LDHBinteractor190.45836.677Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
40 LDHCinteractor50.5001.491Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
41 MMS19interactor40.5003.000DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
42 NOA1interactor100DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
AAA_23 (PF13476): AAA domain
43 OPRM1interactor30.6671.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4231 (PF14015, IPR025325): Protein of unknown function (DUF4231)
DMRT-like (PF15791, IPR031577): Doublesex-and mab-3-related transcription factor C1 and C2
44 PAICSinteractor60.5001.805AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
45 PLD1suppressor21.0000PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
46 PLD2interactor21.0000PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
47 PLEKHA8oncoprotein100GLTP (PF08718, IPR014830): Glycolipid transfer protein (GLTP)
PH (PF00169, IPR001849, SM00233): PH domain
AKNA (PF12443, IPR022150): AT-hook-containing transcription factor
48 PRKACBinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
49 RAB11Aoncoprotein90.7504.100Ras (PF00071, IPR001806, SM00173): Ras family
50 RAB11Boncoprotein100.6227.419Ras (PF00071, IPR001806, SM00173): Ras family
51 RAB1Aoncoprotein180.45141.272Ras (PF00071, IPR001806, SM00173): Ras family
52 RAB1Boncoprotein150.54321.582Ras (PF00071, IPR001806, SM00173): Ras family
53 RAB2Aoncoprotein120.54513.602Ras (PF00071, IPR001806, SM00173): Ras family
54 RAB5Aoncoprotein100.7115.294Ras (PF00071, IPR001806, SM00173): Ras family
55 RAB5Boncoprotein100.57811.371Ras (PF00071, IPR001806, SM00173): Ras family
56 RAB5Concoprotein160.46734.120Ras (PF00071, IPR001806, SM00173): Ras family
57 RAB6Aoncoprotein60.8670.536Ras (PF00071, IPR001806, SM00173): Ras family
58 RAB6Boncoprotein60.9330.222Ras (PF00071, IPR001806, SM00173): Ras family
59 RALAoncoprotein40.5003.000ArgK (PF03308, IPR005129): ArgK protein
Ras (PF00071, IPR001806, SM00173): Ras family
ThiF (PF00899, IPR000594): ThiF family
60 SAR1Ainteractor30.6670.500Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
61 TMEM106Ainteractor100DUF1356 (PF07092, IPR009790): Protein of unknown function (DUF1356)
62 TUFMinteractor90.36113.971GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
63 UBCprotein found in more fusions140.34642.607ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
64 UNKinteractor110.30929.791MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
65 USP39oncoprotein30.6671.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
66 VCAM1interactor100.5787.755C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
67 WBP11interactor100BUD22 (PF09073, IPR015158): BUD22
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SspB (PF04386, IPR007481): Stringent starvation protein B
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARF1parental proteinArf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
2 ARFGAP1interactorArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
3 ARFGAP2interactorArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
4 EIF2B1interactorIF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
5 GALEinteractorGDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
6 GLRX5interactorGlutaredoxin (PF00462, IPR002109): Glutaredoxin

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