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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF876342 is the fusion of parental proteins AKR1A1 (from a repository: Mon Oct 15 15:33:22 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins6 (23.08 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)86 (26.46 %)
The number (and %) of affected PPIs25 (29.07 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI6.077
Assortativity coefficient-0.3402
The network average Clustering coefficient0.600
The number (and %) of a zero Clustering coefficients4 (15.38 %)
The number (and %) of a zero Betweenness Centrality11 (42.31 %)


List of the fusions

PPI for parental proteins: AKR1A1 All fusions
: BF876342;
Proteins found in more fusions TKT (see 5 fusions); TERF2IP (see 1 fusions); GAPDH (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BF876342chimera260.180360.919Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
2 ARFIP1interactor100Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
3 C11orf54interactor40.8330.667DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
4 CFL1interactor110.54516.619Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
5 DAZAP1interactor100.48915.633RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
6 EXOSC4interactor200RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
7 GAPDHoncoprotein80.7622.500Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
8 GNPDA2interactor40.6671.500Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
9 GPIinteractor21.0000PGI (PF00342, IPR001672): Phosphoglucose isomerase
10 GRHPRinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
11 MEMO1interactor200DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
12 NANSinteractor41.0000NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
13 NME1-NME2interactor80.5009.233NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
14 NME2interactor61.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
15 PCBP1oncoprotein80.6437.467Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
16 PGK1interactor41.0000PGK (PF00162, IPR001576): Phosphoglycerate kinase
17 PGK2interactor100PGK (PF00162, IPR001576): Phosphoglycerate kinase
18 PKMoncoprotein90.6396.933PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
19 PTGR1interactor21.0000ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
20 SNX12interactor40.5001.619PX (PF00787, IPR001683, SM00312): PX domain
21 SNX3interactor30.6670.286PX (PF00787, IPR001683, SM00312): PX domain
22 SOD1interactor110.53313.486Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
23 TALDO1interactor70.5715.652TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
24 TERF1interactor80.6675.067TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
25 TERF2IPprotein found in more fusions41.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
26 TKTprotein found in more fusions160.41044.419Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AKR1A1parental proteinAldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
2 ECHS1interactorECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
3 IGHG2oncoproteinC1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
4 PDCD6oncoproteinEF-hand_7 (PF13499, IPR011992): EF-hand domain pair

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