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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BF874520 is the fusion of parental proteins PLCB2 (from a repository: Tue Nov 15 05:26:41 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)9
The number (and %) of the onco-proteins3 (33.33 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)15 (41.67 %)
The number (and %) of affected PPIs8 (53.33 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.444
Assortativity coefficient-0.5590
The network average Clustering coefficient0.345
The number (and %) of a zero Clustering coefficients5 (55.56 %)
The number (and %) of a zero Betweenness Centrality8 (88.89 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PLCB2 All fusions
: BF874520;
Proteins found in more fusions MAPK14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF874520chimera80.10750.000EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
2 ALKoncoprotein100MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
3 MAP2K3interactor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
4 MAP2K6interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
5 MAPK14oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
6 SLC9A3R2interactor100EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
7 TBXA2Rinteractor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
8 TRPM7interactor200Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Ion_trans (PF00520, IPR005821): Ion transport protein
DUF3893 (PF13032, IPR024996): Domain of unknown function (DUF3893)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
9 WDR26interactor100eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 GNAQoncoproteinG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
2 PLCB2parental proteinC2 (PF00168, IPR000008, SM00239): C2 domain
DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
FlgT_N (PF16548, IPR032370): Flagellar assembly protein T, N-terminal domain
3 SNCAinteractorSynuclein (PF01387, IPR001058): Synuclein
4 WDR36interactorUtp21 (PF04192, IPR007319): Utp21 specific WD40 associated putative domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain

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