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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BF870809 is the fusion of parental proteins PRRC2A, AMFR (from a repository: Thu Dec 3 09:53:43 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)65
The number (and %) of the onco-proteins20 (30.77 %)
The number (and %) of the tumor suppressors8 (12.31 %)
Total number of binary PPIs (saturation %)319 (15.34 %)
The number (and %) of affected PPIs64 (20.06 %)
The number of possible different fusions14
PPI diameter2
PPI radius1
The average degree of PPI8.769
Assortativity coefficient-0.3126
The network average Clustering coefficient0.491
The number (and %) of a zero Clustering coefficients9 (13.85 %)
The number (and %) of a zero Betweenness Centrality14 (21.54 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: AMFR,PRRC2A All fusions
: BF870809;
Proteins found in more fusions RBFOX2 (see 2 fusions); EWSR1 (see 2 fusions); IMMT (see 4 fusions); SH3KBP1 (see 1 fusions); KPNB1 (see 2 fusions); ATN1 (see 1 fusions); CUL3 (see 1 fusions); ATXN1 (see 3 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); LUC7L (see 1 fusions); RPA1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF870809chimera640.1102631.953BAT2_N (PF07001, IPR009738): BAT2 N-terminus
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
2 ADRA1Dinteractor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
3 ADRB2interactor70.4003.9867tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 ATN1protein found in more fusions90.39312.622Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
5 ATXN1protein found in more fusions80.4298.233AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
6 ATXN1Linteractor60.6002.233AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
7 BMI1oncoprotein120.43612.733zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
8 BTRConcoprotein100.5007.955WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
9 C1QBPinteractor70.6673.900MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
10 CALCOCO2interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
11 CAND1interactor150.52722.598Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
12 CCR10interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
13 CPSF1interactor100.48910.087CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
HPS3_N (PF14761, IPR029437): Hermansky-Pudlak syndrome 3
14 CUL3protein found in more fusions220.40564.770Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
15 DDX20interactor40.6670.167DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
16 EIF3Eoncoprotein40.6670.833eIF3_N (PF09440, IPR019010): eIF3 subunit 6 N terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
SPESP1 (PF15754, IPR026743): Sperm equatorial segment protein 1
17 EIF3Fsuppressor50.7001.833JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
18 ELAVL1oncoprotein250.351106.685RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 EWSR1oncoprotein160.43832.592RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
20 EXOSC2interactor40.6671.667EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
KH_6 (PF15985, IPR004088): KH domain
21 FBXW11interactor90.6076.486WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
22 FGAinteractor200Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Pentapeptide_2 (PF01469, IPR002989): Pentapeptide repeats (8 copies)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
Fibrinogen_aC (PF12160, IPR021996): Fibrinogen alpha C domain
23 GANABsuppressor40.6671.167Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
DUF5110 (PF17137): Domain of unknown function (DUF5110)
24 GORASP2interactor50.5002.352GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
25 GRB2oncoprotein90.4648.552SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
26 HIST1H3Einteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
27 HNRNPA1interactor210.44260.112RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
28 HNRNPMinteractor140.54920.237RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M
Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
29 IFI16suppressor40.6671.667HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
30 IFT88suppressor100BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
ELYS (PF13934, IPR025151): Nuclear pore complex assembly
TPR_19 (PF14559): Tetratricopeptide repeat
31 IMMTprotein found in more fusions110.33320.356Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
32 JUNoncoprotein40.6670.200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
33 KPNB1protein found in more fusions110.46713.157Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
34 LGR4interactor60.6001.4367tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
35 LUC7Lprotein found in more fusions50.8330.400LUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
36 MAD2L2interactor200HORMA (PF02301, IPR003511): HORMA domain
37 MAN2C1interactor100Alpha-mann_mid (PF09261, IPR015341, SM00872): Alpha mannosidase middle domain
Glyco_hydro_38 (PF01074, IPR000602): Glycosyl hydrolases family 38 N-terminal domain
Glyco_hydro_38C (PF07748, IPR011682): Glycosyl hydrolases family 38 C-terminal domain
38 MYH10interactor90.6115.594IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
39 MYH9suppressor130.50018.998IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
40 NCK2interactor40.6670.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
41 NOP56interactor80.7143.105Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
42 NPHP1interactor31.0000SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FAM176 (PF14851): FAM176 family
Speriolin_N (PF15058, IPR029385): Speriolin N terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
43 NTRK1oncoprotein300.236216.149I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
44 P4HA2interactor100P4Ha_N (PF08336, IPR013547): Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
45 PRMT2interactor21.0000PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
46 PSMA3interactor140.29536.775Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
47 PSMD14interactor60.4677.167JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
48 QARSinteractor41.0000tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
49 RBFOX1interactor50.8330.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
50 RBFOX2protein found in more fusions150.39636.192RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
51 REREoncoprotein50.8000.650Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
52 RPA1suppressor170.52530.209Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
53 RPA2oncoprotein150.57122.010RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
54 RPA3interactor140.6677.154Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
55 SH3KBP1protein found in more fusions70.5332.783Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
56 SHFM1interactor30.6670.667CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
57 SIRT7interactor130.26931.846DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
58 SRPK2oncoprotein110.51114.279DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
59 SSR3interactor100TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
60 TARDBPinteractor190.46440.010RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
61 TP53suppressor160.42932.439DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
62 TUBGCP3interactor80.5716.552Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
63 UBAP2Linteractor80.5006.689CUE (PF02845, IPR003892, SM00546): CUE domain
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2
UBA_4 (PF14555): UBA-like domain
Comm (PF15957, IPR031878): Commissureless
64 USP13interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
65 WWOXsuppressor80.4648.430adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AIFM1oncoproteinPyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
AIF-MLS (PF14962, IPR032773): Mitochondria Localisation Sequence
2 AMFRparental proteinCUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
3 ATP2A2interactorCation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
4 ATXN3interactorJosephin (PF02099, IPR006155): Josephin
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
5 AUP1interactorCUE (PF02845, IPR003892, SM00546): CUE domain
6 BAG6interactorDUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
7 BRI3BPinteractorHemY_N (PF07219, IPR010817): HemY protein N-terminus
BRI3BP (PF14965): Negative regulator of p53/TP53
CLZ (PF16526, IPR032406): C-terminal leucine zipper domain of cyclic nucleotide-gated channels
8 CANXinteractorCalreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
9 CCDC47interactorDUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
10 CD3DinteractorDAP10 (PF07213, IPR009861): DAP10 membrane protein
ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
11 CD82suppressorTetraspannin (PF00335, IPR018499): Tetraspanin family
12 CFTRsuppressorABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
13 CRMP1interactorAmidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
14 CSE1LoncoproteinCAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
15 CYP2E1interactorp450 (PF00067, IPR001128): Cytochrome P450
16 CYP3A4interactorp450 (PF00067, IPR001128): Cytochrome P450
17 DERL1interactorDER1 (PF04511, IPR007599): Der1-like family
18 DERL2interactorDER1 (PF04511, IPR007599): Der1-like family
19 DERL3interactorDER1 (PF04511, IPR007599): Der1-like family
20 DGAT2interactorDAGAT (PF03982, IPR007130): Diacylglycerol acyltransferase
21 DHFRinteractorDHFR_1 (PF00186, IPR001796): Dihydrofolate reductase
22 EEF1A1suppressorGTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
23 ERLIN1interactorRibosomal_L33 (PF00471, IPR001705): Ribosomal protein L33
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
24 ERLIN2interactorBand_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
25 FAF1interactorUBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
26 FAF2interactorDUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
27 GET4interactorDUF410 (PF04190, IPR007317): Protein of unknown function (DUF410)
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
28 GPIinteractorPGI (PF00342, IPR001672): Phosphoglucose isomerase
29 HAX1interactorMlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
30 HERPUD1oncoproteinNeisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31 HMGCRoncoproteinHMG-CoA_red (PF00368, IPR002202): Hydroxymethylglutaryl-coenzyme A reductase
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
32 HSP90B1suppressorCobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
33 HSPA4interactorHerpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
34 HSPA5oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
35 HSPD1suppressorCpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
36 HTR3EinteractorNeur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
37 HTTinteractorHEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
38 INSIG1interactorINSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
39 INSIG2interactorINSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
40 ITPR1interactorIns145_P3_rec (PF08709, IPR014821): Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion_trans (PF00520, IPR005821): Ion transport protein
MIR (PF02815, IPR016093, SM00472): MIR domain
RIH_assoc (PF08454, IPR013662): RyR and IP3R Homology associated
RYDR_ITPR (PF01365, IPR000699): RIH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
41 MAVSinteractorIce_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
42 MDC1suppressorFHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
43 MGRN1interactorzf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
44 NPLOC4interactorNPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
45 OS9interactorDNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
46 OSBPL8interactorCDC45 (PF02724, IPR003874): CDC45-like protein
DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
47 PDIA2interactorThioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
48 PMP22interactorPBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
49 PRRC2Aparental proteinBAT2_N (PF07001, IPR009738): BAT2 N-terminus
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
50 PSMA1interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
51 PSMA2interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
52 PSMA4interactorProteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
53 PSMA5oncoproteinProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
54 PSMA6interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
55 PSMA7interactorProteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
56 PSMB1interactorProteasome (PF00227, IPR001353): Proteasome subunit
57 PSMB2interactorProteasome (PF00227, IPR001353): Proteasome subunit
58 PSMB3interactorProteasome (PF00227, IPR001353): Proteasome subunit
59 PSMB4interactorIntegrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
60 PSMB5interactorProteasome (PF00227, IPR001353): Proteasome subunit
61 PSMB6interactorDUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Proteasome (PF00227, IPR001353): Proteasome subunit
62 PSMB7interactorProteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
63 PSMC2interactorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
64 PSMD3interactorRpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
65 PSMD6interactorRPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
66 PSME4interactorFilament (PF00038, IPR001664): Intermediate filament protein
HEAT (PF02985, IPR000357): HEAT repeat
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
BLM10_mid (PF16507, IPR032430): Proteasome-substrate-size regulator, mid region
67 RHOT1interactorEF_assoc_1 (PF08355, IPR013566): EF hand associated
EF_assoc_2 (PF08356, IPR013567): EF hand associated
Ras (PF00071, IPR001806, SM00173): Ras family
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
68 RNF5interactorzf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
69 RPL5suppressorRibosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
70 SARAFinteractorSARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
71 SEC61BinteractorSec61_beta (PF03911, IPR016482): Sec61beta family
72 SEL1Loncoproteinfn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
73 SELENOSinteractorSelenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
74 SOD1interactorSod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
75 SRPRBinteractorMHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
76 SVIPinteractorSVIP (PF15811, IPR031632): Small VCP/p97-interacting protein
77 SYVN1interactorAlpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
78 TCP1interactorCpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
79 TIMM50interactorNIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
80 TMUB1interactorDUF347 (PF03988, IPR007136): Repeat of Unknown Function (DUF347)
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF4227 (PF14004, IPR025321): Protein of unknown function (DUF4227)
81 TOM1L1interactorGAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
82 TRIM25interactorFes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
83 TRIM28interactorASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
84 UBAC2interactorRhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
85 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
86 UBE2D1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
87 UBE2D2oncoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
88 UBE2D3interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
89 UBE2D4interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
90 UBE2G1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
91 UBE2G2interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
92 UBE2KinteractorUBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
93 UBE2NinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
94 UBE2TinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
95 UBE2WinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
96 UBL4Ainteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
97 UBXN1interactorSelenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
98 UBXN4interactorAsp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
99 UBXN7interactorUBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
100 UFD1LinteractorUFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
101 VCPinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
102 YOD1interactorOTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain

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