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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF849240 is the fusion of parental proteins SFTPC, INPP1 (from a repository: Thu Jan 12 22:24:52 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins4 (36.36 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)21 (38.18 %)
The number (and %) of affected PPIs10 (47.62 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.364
Assortativity coefficient-0.5842
The network average Clustering coefficient0.430
The number (and %) of a zero Clustering coefficients5 (45.45 %)
The number (and %) of a zero Betweenness Centrality9 (81.82 %)


List of the fusions

PPI for parental proteins: INPP1,SFTPC All fusions
: BF849240;
Proteins found in more fusions NDC80 (see 1 fusions); TLK1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BF849240chimera100.06783.000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
2 BRCA1suppressor200BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
3 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
4 LDOC1oncoprotein200DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
5 NDC80protein found in more fusions31.0000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Ndc80_HEC (PF03801, IPR005550): HEC/Ndc80p family
SlyX (PF04102, IPR007236): SlyX
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
6 NECAB2interactor31.0000ABM (PF03992, IPR007138): Antibiotic biosynthesis monooxygenase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
7 NR1D1interactor100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
8 SYCE3interactor100Synaptonemal_3 (PF15191, IPR028145): Synaptonemal complex central element protein 3
9 TLK1protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
10 USHBP1interactor40.6671.000DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
11 WDR12interactor200NLE (PF08154, IPR012972): NLE (NUC135) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 C9orf16interactorUPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
2 CXCL9interactorMRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
SNARE (PF05739, IPR000727, SM00397): SNARE domain
VasL (PF12486, IPR021069): Type VI secretion system, EvfB, or VasL
3 DNAJB9interactorDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
4 DNAJC10interactorDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
5 HSPA5oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
6 INPP1parental proteinInositol_P (PF00459, IPR000760): Inositol monophosphatase family
7 MEOX2interactorHomeobox (PF00046, IPR001356, SM00389): Homeobox domain
8 NEDD4suppressorRota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
9 PQBP1interactorWW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
10 SEC22AinteractorLongin (PF13774, IPR010908): Regulated-SNARE-like domain
11 SEC61GinteractorSecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex
12 SFTPCparental proteinBRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
13 SYNE4interactorKASH (PF10541, IPR012315): Nuclear envelope localisation domain
14 TMEM67interactorEphrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
15 TMEM79interactorMAPEG (PF01124, IPR001129): MAPEG family
16 VCPinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
17 WWP1oncoproteinC2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
18 WWP2interactorWW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)

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