Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BF823719 is the fusion of parental proteins CTSA, ATP6V0A4 (from a repository: Thu Dec 3 09:54:51 2020)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins6 (26.09 %)
The number (and %) of the tumor suppressors3 (13.04 %)
Total number of binary PPIs (saturation %)41 (16.21 %)
The number (and %) of affected PPIs22 (53.66 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.043
Assortativity coefficient-0.5888
The network average Clustering coefficient0.490
The number (and %) of a zero Clustering coefficients9 (39.13 %)
The number (and %) of a zero Betweenness Centrality18 (78.26 %)


List of the fusions

PPI for parental proteins: ATP6V0A4,CTSA All fusions
: BF823719;
Proteins found in more fusions PFKM (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BF823719chimera220.056416.667Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
2 ABCE1interactor41.0000ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 ABHD14Ainteractor21.0000Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
4 ASS1suppressor50.5003.000Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
5 BAG3oncoprotein200BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 BZW2interactor21.0000W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
7 CASP7interactor31.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 CDK2suppressor200Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
9 CTNNBIP1suppressor100ICAT (PF06384, IPR009428): Beta-catenin-interacting protein ICAT
10 CTSDinteractor21.0000A1_Propeptide (PF07966, IPR012848): A1 Propeptide
Asp (PF00026, IPR001461): Eukaryotic aspartyl protease
11 DNAJB2interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
12 FBXO6interactor70.38112.667FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
13 FTOinteractor21.0000FTO_NTD (PF12933, IPR024367): FTO catalytic domain
FTO_CTD (PF12934, IPR024366): FTO C-terminal domain
14 MEPCEinteractor100Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
15 NAXEinteractor100YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
16 NECTIN4oncoprotein100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
17 NEU1interactor31.0000BNR_2 (PF13088, IPR011040): BNR repeat-like domain
18 PEPDinteractor40.5003.000AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
19 PFKMprotein found in more fusions31.0000PFK (PF00365, IPR000023): Phosphofructokinase
20 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
21 RAB2Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
22 TRNT1interactor100PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain
PolyA_pol_RNAbd (PF12627, IPR032828): Probable RNA and SrmB- binding site of polymerase A
23 VAPAinteractor40.8330.667DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain

B a c k    t o    T o p ⇑

List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ATP6V0A4parental proteinV_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
2 CTSAparental proteinPeptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
3 GINS2interactorSld5 (PF05916, IPR021151): GINS complex protein
4 MVDinteractorGHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
5 NAMPTinteractorNAPRTase (PF04095, IPR007229): Nicotinate phosphoribosyltransferase (NAPRTase) family
6 OATinteractorAminotran_3 (PF00202, IPR005814): Aminotransferase class-III
7 SUMO2interactorRad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
8 TIMM9interactorzf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger

B a c k    t o    T o p ⇑