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Fusion ID: Protein names:	BF823276
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Visualization interactions

Cytoscape Web for: BF823276 is the fusion of parental proteins PHF12 (from a repository: Sat Jun 3 23:55:31 2017)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	16
The number (and %) of the onco-proteins	3 (18.75 %)
The number (and %) of the tumor suppressors	5 (31.25 %)
Total number of binary PPIs (saturation %)	77 (64.17 %)
The number (and %) of affected PPIs	15 (19.48 %)
The number of possible different fusions	1
PPI diameter	2
PPI radius	1
The average degree of PPI	9.125
Assortativity coefficient	-0.3817
The network average Clustering coefficient	0.748
The number (and %) of a zero Clustering coefficients	2 (12.50 %)
The number (and %) of a zero Betweenness Centrality	5 (31.25 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: PHF12	All fusions : BF823276;
Proteins found in more fusions

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	BF823276	chimera	15	0.552	60.994	FHA (PF00498, IPR000253, SM00240): FHA domain PHD (PF00628, IPR019787, SM00249): PHD-finger PHF12_MRG_bd (PF16737, IPR031966): PHD finger protein 12 MRG binding domain
2	BRCA1	suppressor	7	1.000	0	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
3	EMSY	oncoprotein	7	1.000	0	ENT (PF03735, IPR005491): ENT domain PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 GTA_TIM (PF13547, IPR025195): GTA TIM-barrel-like domain IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
4	GATAD1	interactor	10	0.911	1.127	GATA (PF00320, IPR000679, SM00401): GATA zinc finger
5	HDAC1	suppressor	14	0.744	6.994	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
6	HDAC2	suppressor	14	0.744	6.994	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
7	HIST3H3	interactor	10	0.889	1.405	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
8	KDM5A	suppressor	9	0.972	0.222	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain FRG1 (PF06229, IPR010414): FRG1-like domain JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase JmjN (PF02375, IPR003349, SM00545): jmjN domain PHD (PF00628, IPR019787, SM00249): PHD-finger PLU-1 (PF08429, IPR013637): PLU-1-like protein zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
9	MORF4L1	interactor	13	0.803	4.194	MRG (PF05712, IPR026541): MRG Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
10	MORF4L2	interactor	10	0.867	1.833	MRG (PF05712, IPR026541): MRG
11	RBBP7	suppressor	12	0.788	4.756	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
12	S100A4	interactor	1	0	0	S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
13	SAP30	interactor	6	1.000	0	Titin_Z (PF09042, IPR015129): Titin Z zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
14	SIN3A	oncoprotein	9	0.889	1.222	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
15	SIN3B	interactor	12	0.803	4.260	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
16	SPICE1	interactor	1	0	0	SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression ANXA2R (PF15721, IPR031449): Annexin-2 receptor JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	PHF12	parental protein	FHA (PF00498, IPR000253, SM00240): FHA domain PHD (PF00628, IPR019787, SM00249): PHD-finger PHF12_MRG_bd (PF16737, IPR031966): PHD finger protein 12 MRG binding domain

B a c k t o T o p ⇑