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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF814941 is the fusion of parental proteins CD63, PUM1 (from a repository: Sun Mar 5 14:17:59 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins7 (41.18 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)54 (39.71 %)
The number (and %) of affected PPIs16 (29.63 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI4.941
Assortativity coefficient-0.1301
The network average Clustering coefficient0.730
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality6 (35.29 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CD63,PUM1 All fusions
: BF814941;
Proteins found in more fusions EGFR (see 2 fusions); ATXN1 (see 3 fusions); RBFOX2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF814941chimera160.217131.467PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
2 ATXN1protein found in more fusions31.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
3 BMI1oncoprotein31.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
4 CAND1interactor60.8000.900Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
5 CCDC8interactor60.7001.400Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
6 EGFRoncoprotein50.8330.400Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
7 EIF5interactor31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
8 FOXG1oncoprotein21.0000SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
9 ITGA4interactor40.6670.400FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
10 MATR3interactor80.4768.067DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
11 NTRK1oncoprotein100.41717.400I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
12 PAICSinteractor31.0000AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
13 RBFOX2protein found in more fusions60.5005.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
14 SEC16Ainteractor50.8000.900APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
15 SEPHS1interactor31.0000AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
16 SMAD1interactor40.6671.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
17 XPO1interactor90.33321.067CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANXA5oncoproteinAnnexin (PF00191, IPR018502, SM00335): Annexin
2 ATP6V1B1interactorATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
3 AURKBinteractorPkinase (PF00069, IPR000719): Protein kinase domain
4 CD63parental proteinTetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
5 CD81interactorTetraspannin (PF00335, IPR018499): Tetraspanin family
6 CD82suppressorTetraspannin (PF00335, IPR018499): Tetraspanin family
7 CD9oncoproteinTetraspannin (PF00335, IPR018499): Tetraspanin family
8 CDKN1AsuppressorCDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
9 CLNS1AinteractorVoldacs (PF03517): Regulator of volume decrease after cellular swelling
10 DSTNinteractorCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
11 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 FAM134CinteractorReticulon (PF02453, IPR003388): Reticulon
13 FBXO6interactorFBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
14 FBXW11interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
15 FOXI2interactorForkhead (PF00250, IPR001766, SM00339): Forkhead domain
16 FOXQ1interactorForkhead (PF00250, IPR001766, SM00339): Forkhead domain
17 HLA-DMBinteractorMHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
18 HLA-DOBinteractorMHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
19 HLA-DRAinteractorMHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
20 HSPB1oncoproteinHSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
21 ITGB1suppressorEGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
22 KIAA0753interactorMNR (PF15718, IPR031447): Protein moonraker
23 KIToncoproteinig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
24 LAGE3interactorPcc1 (PF09341, IPR015419): Transcription factor Pcc1
25 LGALS3oncoproteinGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
26 LGALS8interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
27 LGALS9interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
28 PRR12interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
29 PTGFRNinteractorV-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
30 PUM1parental proteinK_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
YppG (PF14179, IPR025555): YppG-like protein
31 RNF13interactorDNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
32 SAV1oncoproteinWW (PF00397, IPR001202, SM00456): WW domain
33 SDC1oncoproteinHerpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator)
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
34 SDCBPinteractorPDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
35 SIRT7interactorDUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
36 SRFinteractorSRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
37 TSPAN3interactorHum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
38 VKORC1interactorVKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
39 VPS26AinteractorVps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
40 YWHABinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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