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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF752844 is the fusion of parental proteins RUSC1, MT1X (from a repository: Mon May 27 12:51:38 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)9
The number (and %) of the onco-proteins3 (33.33 %)
The number (and %) of the tumor suppressors1 (11.11 %)
Total number of binary PPIs (saturation %)20 (55.56 %)
The number (and %) of affected PPIs8 (40.00 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.889
Assortativity coefficient-0.2472
The network average Clustering coefficient0.501
The number (and %) of a zero Clustering coefficients3 (33.33 %)
The number (and %) of a zero Betweenness Centrality6 (66.67 %)


List of the fusions

PPI for parental proteins: RUSC1,MT1X All fusions
: BF752844;
Proteins found in more fusions APP (see 4 fusions); TRAF6 (see 1 fusions); STUB1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BF752844chimera80.17942.000RUN (PF02759, IPR004012, SM00593): RUN domain
2 APPprotein found in more fusions50.6672.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 DVL2interactor200DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
4 FAM83Hinteractor100DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
5 FAM9Binteractor200Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
6 IKBKGinteractor31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
7 STUB1suppressor41.0000U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
8 TRAF6protein found in more fusions50.6672.000SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
9 UBE2Sinteractor31.0000ALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 HNRNPH2interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
3 MT1Xparental proteinRib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
4 PNMA1oncoproteinPNMA (PF14893, IPR026523): PNMA
5 POT1interactorPOT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
6 RBPMSinteractorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 RUSC1parental proteinRUN (PF02759, IPR004012, SM00593): RUN domain
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
8 TERF1interactorTRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
9 TERF2IPinteractorBRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
10 VKORC1interactorVKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
11 WWP2interactorWW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)

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