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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF476718 is the fusion of parental proteins ABCA8, HMGCS1 (from a repository: Sun Feb 18 03:26:22 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins3 (11.54 %)
The number (and %) of the tumor suppressors4 (15.38 %)
Total number of binary PPIs (saturation %)40 (12.31 %)
The number (and %) of affected PPIs25 (62.50 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.769
Assortativity coefficient-0.6614
The network average Clustering coefficient0.318
The number (and %) of a zero Clustering coefficients15 (57.69 %)
The number (and %) of a zero Betweenness Centrality20 (76.92 %)


List of the fusions

PPI for parental proteins: LOC105371874,HMGCS1 All fusions
: BF476718;
Proteins found in more fusions MAPK9 (see 3 fusions); SPDL1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BF476718chimera250.037563.667ABC2_membrane (PF01061, IPR013525): ABC-2 type transporter
ABC_tran (PF00005, IPR003439): ABC transporter
HMG_CoA_synt_C (PF08540, IPR013746): Hydroxymethylglutaryl-coenzyme A synthase C terminal
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
2 ATP6V1E1interactor21.0000vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
3 CLN5interactor100CLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
4 DARSinteractor40.8330.667tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
5 FSD1interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
DUF4945 (PF16303, IPR032544): Domain of unknown function (DUF4945)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
6 IARSinteractor31.0000Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
7 IMPDH1interactor100IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
8 KARSinteractor40.8330.667tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
9 MAPK9suppressor40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
10 MBD5interactor100MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pap_E4 (PF02711, IPR003861): E4 protein
PWWP (PF00855, IPR000313, SM00293): PWWP domain
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
11 MVDinteractor200GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
12 NEDD8interactor200ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
13 NFYAinteractor100CBFB_NFYA (PF02045, IPR001289): CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
MSP1_C (PF07462, IPR010901): Merozoite surface protein 1 (MSP1) C-terminus
FixG_C (PF11614, IPR032879): IG-like fold at C-terminal of FixG, putative oxidoreductase
DUF4237 (PF14021, IPR025331): Protein of unknown function (DUF4237)
14 NMD3interactor21.0000DUF1816 (PF08846, IPR014945): Domain of unknown function (DUF1816)
NMD3 (PF04981, IPR007064): NMD3 family
HGTP_anticodon2 (PF12745, IPR024435): Anticodon binding domain of tRNAs
15 OR10H3interactor1007tm_4 (PF13853): Olfactory receptor
16 OR5F1interactor1007tm_4 (PF13853): Olfactory receptor
17 PEG10oncoprotein100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Retrotrans_gag (PF03732, IPR005162): Retrotransposon gag protein
Asp_protease_2 (PF13650): Aspartyl protease
zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
PRIMA1 (PF16101): Proline-rich membrane anchor 1
DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
18 PFN2interactor100Profilin (PF00235, IPR005455, SM00392): Profilin
19 PPP2CBsuppressor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
20 RAD23Bsuppressor40.5003.000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
21 SCP2interactor100SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
22 SERPINB5suppressor21.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
23 SPDL1protein found in more fusions200Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF2911 (PF11138, IPR021314): Protein of unknown function (DUF2911)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
24 SPG21interactor100Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
25 UFM1interactor21.0000Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
26 XPNPEP1interactor60.4009.000Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ABCA8interactorABC2_membrane (PF01061, IPR013525): ABC-2 type transporter
ABC_tran (PF00005, IPR003439): ABC transporter
RseC_MucC (PF04246, IPR007359): Positive regulator of sigma(E), RseC/MucC
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
2 CDK5R1oncoproteinCDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
3 HMGCS1parental proteinHMG_CoA_synt_C (PF08540, IPR013746): Hydroxymethylglutaryl-coenzyme A synthase C terminal
HMG_CoA_synt_N (PF01154, IPR013528): Hydroxymethylglutaryl-coenzyme A synthase N terminal

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