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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF368021 is the fusion of parental proteins AKAP13, USP47 (from a repository: Sun Mar 19 11:40:31 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins7 (22.58 %)
The number (and %) of the tumor suppressors2 (6.45 %)
Total number of binary PPIs (saturation %)72 (15.48 %)
The number (and %) of affected PPIs30 (41.67 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.806
Assortativity coefficient-0.3538
The network average Clustering coefficient0.584
The number (and %) of a zero Clustering coefficients8 (25.81 %)
The number (and %) of a zero Betweenness Centrality20 (64.52 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: USP47,AKAP13 All fusions
: BF368021;
Proteins found in more fusions GRK5 (see 4 fusions); APC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF368021chimera300.067729.000Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
2 AP4M1interactor21.0000Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
3 APCsuppressor50.6671.667APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4 ATP6V1Hinteractor40.6672.000V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
5 AURKAoncoprotein70.4677.333Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
6 BTRConcoprotein50.6671.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
7 CTNNAL1interactor100Vinculin (PF01044, IPR006077): Vinculin family
8 DDI1interactor100Asp_protease (PF09668, IPR019103): Aspartyl protease
T2SSE_N (PF05157, IPR007831): Type II secretion system (T2SS), protein E, N-terminal domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
9 FBXW11interactor41.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
10 FOXK1interactor40.8330.667Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
11 FOXK2interactor31.0000FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
12 GMPPBinteractor21.0000Hexapep (PF00132, IPR001451): Bacterial transferase hexapeptide (six repeats)
NTP_transferase (PF00483, IPR005835): Nucleotidyl transferase
13 GRK5protein found in more fusions40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
14 HDAC6oncoprotein60.6003.667Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
15 HOGA1interactor200DHDPS (PF00701, IPR002220, SM01130): Dihydrodipicolinate synthetase family
16 KATNA1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
17 KIFC3oncoprotein200Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
18 NTRK1oncoprotein60.6003.667I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
19 OBFC1interactor21.0000STN1_2 (PF09170, IPR015253): CST, Suppressor of cdc thirteen homolog, complex subunit STN1
RUN (PF02759, IPR004012, SM00593): RUN domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
Stn1 (PF10451, IPR018856): Telomere regulation protein Stn1
20 PDXDC1interactor40.6672.000Pyridoxal_deC (PF00282, IPR002129): Pyridoxal-dependent decarboxylase conserved domain
21 PLA2G2Asuppressor200Phospholip_A2_1 (PF00068, IPR016090, SM00085): Phospholipase A2
22 POLR2Minteractor21.0000GCOM2 (PF15328, IPR026213): Putative GRINL1B complex locus protein 2
23 PSMD5interactor100Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
24 RBPJinteractor21.0000BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
25 SIRT7interactor31.0000DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
26 SNCAinteractor31.0000Synuclein (PF01387, IPR001058): Synuclein
27 UBBinteractor21.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
28 UBXN1interactor200Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
29 WDR44interactor31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
30 WRAP73interactor31.0000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
IKI3 (PF04762, IPR006849): IKI3 family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2555 (PF10742, IPR019678): Protein of unknown function (DUF2555)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 XPO1interactor130.21859.333CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AKAP13parental proteinAPG6 (PF04111, IPR007243): Autophagy protein Apg6
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
RII_binding_1 (PF10522, IPR018459): RII binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
2 APPinteractorAPP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 BAK1oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
4 ESR1suppressorOest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
5 GNA12oncoproteinG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
6 GNAQoncoproteinG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
7 MAP1LC3AinteractorAtg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
8 MAPK14oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
9 MTRinteractorB12-binding (PF02310, IPR006158): B12 binding domain
B12-binding_2 (PF02607, IPR003759, SM01018): B12 binding domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
Met_synt_B12 (PF02965, IPR004223): Vitamin B12 dependent methionine synthase, activation domain
Pterin_bind (PF00809, IPR000489): Pterin binding enzyme
S-methyl_trans (PF02574, IPR003726): Homocysteine S-methyltransferase
DUF2760 (PF10816, IPR021212): Domain of unknown function (DUF2760)
10 PPARAsuppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
11 PRKACAinteractorPkinase (PF00069, IPR000719): Protein kinase domain
12 PRKAR2AinteractorRIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
13 PRKAR2BinteractorRIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
14 PRKCAinteractorC2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
15 PRKCHinteractorC2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
16 PRKD1oncoproteinPH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
17 RANBP2oncoproteinPro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693)
IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain
Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
18 RHOAsuppressorRas (PF00071, IPR001806, SM00173): Ras family
19 RTKNinteractorAnillin (PF08174, IPR012966): Cell division protein anillin
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
PH (PF00169, IPR001849, SM00233): PH domain
20 RXRBinteractorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
21 SRPK2oncoproteinDUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
22 THRAsuppressorC1_2 (PF03107, IPR004146): C1 domain
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
23 USP47parental proteinSad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
24 YWHABinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
25 YWHAGinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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