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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF222724 is the fusion of parental proteins DNMT3L, IGFBP2 (from a repository: Sat Feb 3 10:11:37 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)6
The number (and %) of the onco-proteins2 (33.33 %)
The number (and %) of the tumor suppressors2 (33.33 %)
Total number of binary PPIs (saturation %)12 (80.00 %)
The number (and %) of affected PPIs5 (41.67 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.000
Assortativity coefficient-0.2041
The network average Clustering coefficient0.733
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality2 (33.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: LOC105372833,IGFBP2 All fusions
: BF222724;
Proteins found in more fusions RXRA (see 2 fusions); NFKB1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF222724chimera50.4009.000IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
2 HDAC1suppressor40.6671.000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
3 MECP2interactor21.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
4 NFKB1suppressor40.6671.000Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
5 NR1I3interactor21.0000PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
6 RXRAoncoprotein40.6671.000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AESinteractorTLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
2 ASH2LinteractorSPRY (PF00622, IPR003877, SM00449): SPRY domain
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
3 ATF1oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
4 ATF2oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
5 ATF3suppressorbZIP_1 (PF00170, IPR004827): bZIP transcription factor
6 ATF4oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
7 BLZF1interactorDASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
ZapB (PF06005, IPR009252): Cell division protein ZapB
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
8 CDX2suppressorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Caudal_act (PF04731, IPR006820): Caudal like protein activation region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
9 CREB1oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
10 CREBL2interactorbZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
11 CREMsuppressorbZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
12 DDIT3oncoproteinIFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
13 DLX4oncoproteinHomeobox (PF00046, IPR001356, SM00389): Homeobox domain
14 DMTF1suppressorMyb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3818 (PF12825, IPR024554): Domain of unknown function in PX-proteins (DUF3818)
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
15 DNMT3AsuppressorDNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
16 DNMT3BsuppressorDNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
17 DNMT3Lparental proteinCEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
18 DR1interactorCBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
SLED (PF12140, IPR021987): SLED domain
19 E2F3suppressorE2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
20 E2F4suppressorE2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
SPX (PF03105, IPR004331): SPX domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
21 E2F5interactorE2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
FAD_binding_5 (PF00941, IPR002346): FAD binding domain in molybdopterin dehydrogenase
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
PRIMA1 (PF16101): Proline-rich membrane anchor 1
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
22 E2F6oncoproteinBRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
23 EGR1suppressorzf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3432 (PF11914, IPR021839): Domain of unknown function (DUF3432)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
24 EGR2suppressorzf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
25 EGR4interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
26 ESR1suppressorOest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
27 ESR2suppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
28 ESRRGoncoproteinzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
29 ETS1oncoproteinEts (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
30 F2RL1interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF4064 (PF13273, IPR025273): Protein of unknown function (DUF4064)
31 FOSoncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
32 FOSBoncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
Motilin_ghrelin (PF04644, IPR006738): Motilin/ghrelin
33 FOSL1oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
34 FOSL2oncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
35 GATA1oncoproteinGATA (PF00320, IPR000679, SM00401): GATA zinc finger
Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
36 GMEB1interactorAdeno_PV (PF03910, IPR005608): Adenovirus minor core protein PV
SAND (PF01342, IPR000770, SM00258): SAND domain
37 GSDMBinteractorGasdermin (PF04598, IPR007677): Gasdermin family
38 GSK3BsuppressorPkinase (PF00069, IPR000719): Protein kinase domain
39 GTF2H2interactorC1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase
Ssl1 (PF04056, IPR007198): Ssl1-like
zf-HIT (PF04438, IPR007529): HIT zinc finger
UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547
zf-C2H2_4 (PF13894): C2H2-type zinc finger
40 GTF2IinteractorGTF2I (PF02946, IPR004212): GTF2I-like repeat
41 GTF3C5interactorPox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
Tau95 (PF09734, IPR019136): RNA polymerase III transcription factor (TF)IIIC subunit
42 HAND1interactorHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
43 HAND2interactorHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
44 HEYinteractorNA
45 HIST2H2ACinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
46 HIST2H2BEinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
47 HIST2H3CinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
48 HIST2H4AinteractorCENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
49 HNF4Ginteractorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
50 HOXA5interactorChorion_2 (PF03964, IPR005649): Chorion family 2
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Terminase_5 (PF06056, IPR010332): Putative ATPase subunit of terminase (gpP-like)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
51 HOXC11oncoproteinDUF3528 (PF12045, IPR021918): Protein of unknown function (DUF3528)
52 ID1interactorHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
53 IGF1suppressorInsulin (PF00049, IPR016179, SM00078): Insulin/IGF/Relaxin family
DUF2865 (PF11064, IPR021293): Protein of unknown function (DUF2865)
54 IGFBP2parental proteinIGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
Cys_rich_CWC (PF14375, IPR032720): Cysteine-rich CWC
55 INO80BinteractorPAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
zf-HIT (PF04438, IPR007529): HIT zinc finger
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
56 JUNoncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
57 JUNBoncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
58 KLF12interactorzf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Macoilin (PF09726, IPR019130): Transmembrane protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
59 LDB1oncoproteinLIM_bind (PF01803): LIM-domain binding protein
60 LHX2interactorDUF1314 (PF07013, IPR010741): Protein of unknown function (DUF1314)
LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
61 MAFKoncoproteinbZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
62 MAXsuppressorATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
63 MED7interactorMed7 (PF05983, IPR009244): MED7 protein
DotU (PF09850, IPR017732): Type VI secretion system protein DotU
64 MEF2AoncoproteinTFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
65 MEF2DoncoproteinDUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
66 NFIL3interactorVert_IL3-reg_TF (PF06529, IPR010533): Vertebrate interleukin-3 regulated transcription factor
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
67 NR1H2oncoproteinzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
68 NR1I2suppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
69 NR2E1interactorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
70 NR3C1interactorGCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
71 NR6A1interactorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
72 NUDT21interactorNUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
73 PAX6suppressorPAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
74 PHPT1interactorOcnus (PF05005, IPR007702): Janus/Ocnus family (Ocnus)
75 RELAoncoproteinDEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
76 RSL24D1interactorRibosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
CALM_bind (PF16025): Calcium-dependent calmodulin binding
77 SMAD1interactorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
78 SMAD3oncoproteinMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
79 SMAD4suppressorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
80 TP53suppressorDEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
81 YY1interactorzf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail

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