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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF081503 is the fusion of parental proteins UBQLN2 (from a repository: Mon Dec 5 23:22:57 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)78
The number (and %) of the onco-proteins22 (28.21 %)
The number (and %) of the tumor suppressors9 (11.54 %)
Total number of binary PPIs (saturation %)395 (13.15 %)
The number (and %) of affected PPIs77 (19.49 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI9.462
Assortativity coefficient-0.1505
The network average Clustering coefficient0.603
The number (and %) of a zero Clustering coefficients2 (2.56 %)
The number (and %) of a zero Betweenness Centrality14 (17.95 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: UBQLN2 All fusions
: BF081503;
Proteins found in more fusions PSMC2 (see 1 fusions); UBQLN1 (see 2 fusions); RNF11 (see 1 fusions); EPS15 (see 1 fusions); HTT (see 1 fusions); SNAP23 (see 1 fusions); UBC (see 1 fusions); PRPF40A (see 2 fusions); TPD52L2 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF081503chimera770.1003615.922Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
2 AARSD1interactor50.6003.167tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3 ADSLinteractor80.8211.852DUF1331 (PF07048, IPR009762): Protein of unknown function (DUF1331)
Lyase_1 (PF00206, IPR022761): Lyase
ADSL_C (PF10397, IPR019468, SM00998): Adenylosuccinate lyase C-terminus
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
DUF4089 (PF13318, IPR025148): Protein of unknown function (DUF4089)
4 ATXN7interactor41.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
5 BCL2L11suppressor100Bclx_interact (PF08945, IPR015040): Bcl-x interacting, BH3 domain
Bim_N (PF06773, IPR014771): Bim protein N-terminus
6 BIDoncoprotein31.0000BID (PF06393, IPR010479): BH3 interacting domain (BID)
7 C12orf10interactor21.0000UPF0160 (PF03690, IPR003226): Uncharacterised protein family (UPF0160)
8 C1QAoncoprotein21.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
9 CALUinteractor100.42217.488EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
10 CD93interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Plasmod_Pvs28 (PF06247, IPR010423): Pvs28 EGF domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
TMEM154 (PF15102, IPR028064): TMEM154 protein family
11 CUL5suppressor110.47317.825Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
12 DNAJB1suppressor100.44418.638DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
13 EDEM1interactor30.6670.400Glyco_hydro_47 (PF01532, IPR001382): Glycosyl hydrolase family 47
14 EEF1B2interactor51.0000EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
15 ELAVL1oncoprotein190.22293.924RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
16 EMC3interactor40.6672.000DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
17 EMC8interactor31.0000UPF0172 (PF03665, IPR005366): Uncharacterised protein family (UPF0172)
18 EPN1interactor60.6673.167ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
19 EPN2interactor21.0000ENTH (PF01417, IPR001026, SM00273): ENTH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
20 EPS15oncoprotein90.6075.537Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
21 FAF2interactor90.4298.927DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
22 FBXO25suppressor50.4003.248Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
23 HERC3interactor50.7003.000RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
24 HERC6interactor31.0000RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
25 HERPUD1oncoprotein50.8000.686Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
26 HNRNPA1interactor110.6447.021RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
27 HNRNPA3oncoprotein80.8211.390IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
28 HNRNPUinteractor120.53014.676CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
29 HSPA13interactor31.0000HSP70 (PF00012, IPR013126): Hsp70 protein
30 HTTprotein found in more fusions70.4674.667HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
31 IGBP1interactor80.35713.133TAP42 (PF04177, IPR007304): TAP42-like family
32 INSIG2interactor50.6001.933INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
33 MARCKSsuppressor60.6672.450MARCKS (PF02063, IPR002101): MARCKS family
34 MMGT1interactor40.6672.000MMgT (PF10270, IPR018937): Membrane magnesium transporter
35 NPLOC4interactor110.6189.694NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
36 NTRK1oncoprotein330.242255.254I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
37 P4HBinteractor100.44413.750Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
38 PDE12interactor100.7115.386Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
39 PFDN2interactor70.4299.800Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
40 PLAURoncoprotein30.6670.286Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
41 PRKACAinteractor50.7002.000Pkinase (PF00069, IPR000719): Protein kinase domain
42 PRPF40Aprotein found in more fusions80.5244.386FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
43 PSMA2interactor130.7128.065Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
44 PSMA5oncoprotein110.7643.983Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
45 PSMA6interactor120.7276.954Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
46 PSMC1interactor130.64114.020AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
47 PSMC2protein found in more fusions180.48544.802AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
48 RAD23Aoncoprotein170.52527.606UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
49 RAD23Bsuppressor180.47142.931K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
50 RNASEH2Binteractor30.6671.000RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
51 RNF11protein found in more fusions60.8001.067zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
52 RNF185interactor90.8211.419zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
53 RNH1suppressor21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Metallothio_Euk (PF12749, IPR024306): Eukaryotic metallothionein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
54 RPA2oncoprotein170.30169.444RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
55 SEC23Ainteractor50.6002.900Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
56 SHFM1interactor120.6977.289CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
57 SNAP23protein found in more fusions31.0000DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SNAP-25 (PF00835, IPR000928): SNAP-25 family
DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089)
58 SSSCA1interactor100.55610.586Auto_anti-p27 (PF06677, IPR009563): Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)
59 STAMinteractor80.4647.752GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
60 TARDBPinteractor100.6395.702RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
61 TP53suppressor120.43617.910DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
62 TPD52L2protein found in more fusions90.42911.186TPD52 (PF04201, IPR007327): Tumour protein D52 family
63 TTC1interactor60.4007.167TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
64 UBA2interactor130.42330.252ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
65 UBCprotein found in more fusions380.230362.540ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
66 UBE2Ainteractor80.6193.919UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
67 UBE3Aoncoprotein130.54516.602HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
68 UBL7oncoprotein90.5839.919UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
69 UBQLN1protein found in more fusions330.206305.446Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
70 UBQLN4interactor160.37141.040CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
71 USP34interactor100.55610.036Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUF3517 (PF12030, IPR021905): Domain of unknown function (DUF3517)
72 USP9Xinteractor110.45519.319DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
73 VBP1interactor50.4005.400Prefoldin (PF02996, IPR004127): Prefoldin subunit
74 WDR4interactor60.7331.419WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
75 YAP1suppressor60.6003.400Bindin (PF02084, IPR000775): Bindin
WW (PF00397, IPR001202, SM00456): WW domain
GspL_C (PF12693, IPR025691): GspL periplasmic domain
FAM181 (PF15238, IPR029359): FAM181
76 ZFYVE19interactor100.37820.133Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
77 ZMYM3interactor21.0000NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
YHS (PF04945, IPR007029): YHS domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
78 ZRANB2interactor70.7143.186RRN3 (PF05327, IPR007991): RNA polymerase I specific transcription initiation factor RRN3
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 EMC7interactorDUF2012 (PF09430, IPR019008): Protein of unknown function (DUF2012)
2 UBQLN2parental proteinClathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B

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