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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BF063267 is the fusion of parental proteins CTRL, LMF2 (from a repository: Sun May 6 13:03:24 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins2 (12.50 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)22 (18.33 %)
The number (and %) of affected PPIs15 (68.18 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.375
Assortativity coefficient-0.6055
The network average Clustering coefficient0.169
The number (and %) of a zero Clustering coefficients11 (68.75 %)
The number (and %) of a zero Betweenness Centrality11 (68.75 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CTRL,LMF2 All fusions
: BF063267;
Proteins found in more fusions APP (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BF063267chimera150.038199.333LMF1 (PF06762, IPR009613): Lipase maturation factor
2 A4GNTinteractor100Gb3_synth (PF04572, IPR007652): Alpha 1,4-glycosyltransferase conserved region
Gly_transf_sug (PF04488, IPR007577): Glycosyltransferase sugar-binding region containing DXD motif
3 APPprotein found in more fusions200APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ATP1B4interactor100Gcd10p (PF04189, IPR007316): Gcd10p family
Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
5 CALCOCO2interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
6 ENPP6interactor100Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
7 FBXO6interactor30.6670.667FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
8 GABREinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
9 HMOX2interactor30.6670.667Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
10 HTR3Cinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
11 KRT31interactor100Filament (PF00038, IPR001664): Intermediate filament protein
12 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
13 KRTAP10-3interactor200Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
14 TCTN2interactor30.6670.667DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
15 TCTN3interactor30.6670.667DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
16 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANKRD40interactorAnk_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
2 CTRLparental proteinTrypsin (PF00089, IPR001254, SM00020): Trypsin
3 LMF2parental proteinLMF1 (PF06762, IPR009613): Lipase maturation factor
4 PDIA5interactorThioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
5 PSME1interactorPA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
6 PSME2interactorPA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit

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