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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BE925576 is the fusion of parental proteins SDC3, ADGRE5 (from a repository: Wed Feb 22 09:44:00 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins5 (38.46 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)20 (25.64 %)
The number (and %) of affected PPIs12 (60.00 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.615
Assortativity coefficient-0.6793
The network average Clustering coefficient0.339
The number (and %) of a zero Clustering coefficients7 (53.85 %)
The number (and %) of a zero Betweenness Centrality10 (76.92 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ADGRE5,SDC3 All fusions
: BE925576;
Proteins found in more fusions HNRNPD (see 1 fusions); FYN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE925576chimera120.076118.0007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_MSP1_1 (PF12946, IPR024730): MSP1 EGF domain 1
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
2 ARRB1interactor31.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
3 ARRB2interactor40.6672.000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4 CSKinteractor40.6672.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5 FYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
6 GOLT1Binteractor100Got1 (PF04178, IPR007305): Got1/Sft2-like family
7 HNRNPDoncoprotein31.0000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 KNL1oncoprotein100DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
9 KRTAP10-3interactor200Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
10 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
11 TMEM171interactor100TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
12 TMEM63Binteractor100RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
13 XRN1interactor100XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADGRE5parental protein7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_MSP1_1 (PF12946, IPR024730): MSP1 EGF domain 1
2 CTTNoncoproteinFadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
3 FGF2oncoproteinFGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
4 KRTAP5-9interactorEry_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
5 SDC3parental proteinGlycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
6 TUBA1AoncoproteinTubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
7 TUBBinteractorTubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
8 TUBB2AinteractorTubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain

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