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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BE895751 is the fusion of parental proteins CDK6 (from a repository: Wed Dec 28 17:35:41 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)108
The number (and %) of the onco-proteins40 (37.04 %)
The number (and %) of the tumor suppressors22 (20.37 %)
Total number of binary PPIs (saturation %)440 (7.62 %)
The number (and %) of affected PPIs107 (24.32 %)
The number of possible different fusions14
PPI diameter2
PPI radius1
The average degree of PPI7.519
Assortativity coefficient-0.3480
The network average Clustering coefficient0.541
The number (and %) of a zero Clustering coefficients19 (17.59 %)
The number (and %) of a zero Betweenness Centrality43 (39.81 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CDK6 All fusions
: BE895751;
Proteins found in more fusions RUNX1 (see 1 fusions); SRSF2 (see 1 fusions); HSP90AA1 (see 2 fusions); SOX5 (see 1 fusions); MCM2 (see 1 fusions); SRSF1 (see 1 fusions); HSF1 (see 3 fusions); EZH2 (see 1 fusions); ATXN1 (see 3 fusions); CDC37 (see 2 fusions); PML (see 4 fusions); CCND1 (see 1 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE895751chimera1070.0538929.510Pkinase (PF00069, IPR000719): Protein kinase domain
2 ABI2suppressor31.0000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3 AMY2Ainteractor100Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
Alpha-amylase_C (PF02806, IPR006048, SM00632): Alpha amylase, C-terminal all-beta domain
4 ANKRD12oncoprotein21.0000CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
UPF0767 (PF15990, IPR031933): UPF0767 family
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
5 ARoncoprotein130.36423.269Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
6 ATF6Binteractor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
7 ATXN1protein found in more fusions70.3339.067AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
8 BCL11Aoncoprotein40.6670.400BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
9 CASC3oncoprotein50.6002.567Btz (PF09405, IPR018545, SM01044): CASC3/Barentsz eIF4AIII binding
UPF0560 (PF10577, IPR018890): Uncharacterised protein family UPF0560
PRIMA1 (PF16101): Proline-rich membrane anchor 1
10 CCNA2oncoprotein150.47317.173Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
11 CCND1oncoprotein150.42921.592Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
12 CCND2oncoprotein100.5786.113Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
13 CCND3oncoprotein100.5339.308Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
14 CCNE1oncoprotein160.41731.024Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
15 CCNT1oncoprotein60.7002.333Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
MDFI (PF15316, IPR026134): MyoD family inhibitor
16 CCNT2interactor40.5001.583Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
17 CDC37protein found in more fusions90.5009.786CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
18 CDC6oncoprotein100.6006.451Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
19 CDK2suppressor340.246254.002Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
20 CDK4oncoprotein340.182366.282Pkinase (PF00069, IPR000719): Protein kinase domain
21 CDK5R1oncoprotein50.7000.671CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
22 CDK7oncoprotein90.6074.695Pkinase (PF00069, IPR000719): Protein kinase domain
23 CDKL3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
24 CDKN1Asuppressor150.52421.255CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
25 CDKN1Bsuppressor130.48720.246CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
26 CDKN1Csuppressor80.6432.704CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
TonB_N (PF16031): TonB N-terminal region
27 CDKN2Asuppressor120.42420.953Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
28 CDKN2Bsuppressor30.6671.000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
29 CDKN2Csuppressor50.5002.400Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
30 CDKN2Doncoprotein21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
31 CLASRPinteractor30.6671.000Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Pap_E4 (PF02711, IPR003861): E4 protein
RAP1 (PF07218, IPR009864): Rhoptry-associated protein 1 (RAP-1)
S-antigen (PF05756, IPR008825): S-antigen protein
Transformer (PF06495, IPR010519): Fruit fly transformer protein
DRY_EERY (PF09750, IPR019147, SM01141): Alternative splicing regulator
LRRFIP (PF09738, IPR019139): LRRFIP family
DUF4554 (PF15091, IPR028040): Domain of unknown function (DUF4554)
32 CTNNB1oncoprotein140.39625.651Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
33 DDIT3oncoprotein200IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
34 DMBT1suppressor100CUB (PF00431, IPR000859, SM00042): CUB domain
Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
Zona_pellucida (PF00100, IPR001507, SM00241): Zona pellucida-like domain
35 EBF4interactor100TIG (PF01833, IPR002909): IPT/TIG domain
COE1_DBD (PF16422, IPR032200): Transcription factor COE1 DNA-binding domain
COE1_HLH (PF16423, IPR032201): Transcription factor COE1 helix-loop-helix domain
36 EIF2AK1interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
37 EIF4ENIF1interactor30.6670.667EIF4E-T (PF10477, IPR018862): Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
38 ELAVL1oncoprotein220.195135.839RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
39 ELK1oncoprotein31.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
40 EZH2suppressor150.36336.715CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
41 FBXO7interactor30.6670.400Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
F-box-like (PF12937, IPR001810): F-box-like
42 FOXM1oncoprotein60.8000.608EspF (PF04806, IPR006891): EspF protein repeat
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
43 FOXO3suppressor70.6672.037Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
44 HIST1H1Ainteractor100.5787.326Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
45 HSF1protein found in more fusions41.0000DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
46 HSP90AA1oncoprotein200.31077.237HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
47 ISL1interactor31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
48 KIF26Binteractor31.0000Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Microtub_bd (PF16796, IPR031852): Microtubule binding
49 KLF10suppressor31.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
AAA_33 (PF13671): AAA domain
50 LPIN1interactor21.0000Lipin_N (PF04571, IPR007651): lipin, N-terminal conserved region
LNS2 (PF08235, IPR013209, SM00775): LNS2 (Lipin/Ned1/Smp2)
DUF3678 (PF12435, IPR022146): Protein of unknown function (DUF3678)
LZ_Tnp_IS66 (PF13007, IPR024463): Transposase C of IS166 homeodomain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
Lipin_mid (PF16876, IPR031703): Lipin/Ned1/Smp2 multi-domain protein middle domain
51 MCM10interactor90.4727.584Mcm10 (PF09332, IPR015411): Mcm10 replication factor
zf-primase (PF09329, IPR015408): Primase zinc finger
AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
52 MCM2oncoprotein120.5648.883AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
53 MEF2Doncoprotein21.0000DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
54 MLLT3oncoprotein50.4005.000Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
NKAP (PF15692): NF-kappa-B-activating protein
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
55 MSL3interactor100GET2 (PF08690, IPR028143): GET complex subunit GET2
MRG (PF05712, IPR026541): MRG
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
56 MYConcoprotein210.31685.102HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
57 MZF1interactor40.6672.000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
58 N4BP1interactor100Enterotoxin_b (PF01376, IPR001835): Heat-labile enterotoxin beta chain
RNase_Zc3h12a (PF11977, IPR021869): Zc3h12a-like Ribonuclease NYN domain
59 NFATC3oncoprotein100DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
60 NIPBLoncoprotein21.0000DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Zip (PF02535, IPR003689): ZIP Zinc transporter
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion
Nipped-B_C (PF12830, IPR024986): Sister chromatid cohesion C-terminus
HEAT_2 (PF13646): HEAT repeats
DNA_repr_REX1B (PF14966): DNA repair REX1-B
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
61 NTRK1oncoprotein300.197260.292I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
62 NUMA1oncoprotein50.8000.622Colicin (PF01024, IPR000293): Colicin pore forming domain
Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
63 PIGRoncoprotein100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
64 PMLsuppressor160.35243.516zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
65 POGZinteractor100DDE_1 (PF03184, IPR004875): DDE superfamily endonuclease
Rubredoxin (PF00301, IPR024935): Rubredoxin
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
HTH_28 (PF13518): Helix-turn-helix domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
66 PPARGC1Ainteractor40.6671.667Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
67 PPHLN1interactor30.6670.667Lge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
68 PPM1Binteractor31.0000PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
69 PPP2CAsuppressor70.5245.805Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
70 PRXinteractor200Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
CCDC74_C (PF14917, IPR029422): Coiled coil protein 74, C terminal
71 PSMA3interactor80.5715.221Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
72 RB1suppressor200.34265.680RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
73 RBL1suppressor120.45514.409RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
74 RBL2suppressor150.41925.703CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
SLH (PF00395, IPR001119): S-layer homology domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
75 RBM23interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
RSRP (PF17069): Arginine/Serine-Rich protein 1
76 RCHY1suppressor40.6670.500C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
77 RTFDC1interactor100Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
78 RUNX1suppressor50.8330.250Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
79 SENP3interactor60.6674.250Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
80 SIRT1suppressor180.26579.546DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
81 SLBPinteractor21.0000SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
82 SNIP1interactor80.39313.019FHA (PF00498, IPR000253, SM00240): FHA domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
FAM176 (PF14851): FAM176 family
83 SORBS1interactor31.0000SH3_2 (PF07653, IPR011511): Variant SH3 domain
Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
SCAB-ABD (PF16711, IPR032012): Actin-binding domain of plant-specific actin-binding protein
84 SOX10oncoprotein100Beta-lactamase (PF00144, IPR001466): Beta-lactamase
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
85 SOX5oncoprotein200HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOAR (PF16533, IPR032393): STIM1 Orai1-activating region
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
86 SRSF1protein found in more fusions100.5569.056Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
87 SRSF11interactor50.9000.400Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Transformer (PF06495, IPR010519): Fruit fly transformer protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
88 SRSF12interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
89 SRSF2oncoprotein70.6674.067RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
90 SRSF7interactor80.6794.408RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-CCHC (PF00098, IPR001878): Zinc knuckle
91 SYNPO2suppressor21.0000Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
92 TCEB3Binteractor100Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
FAM176 (PF14851): FAM176 family
93 TFDP1oncoprotein60.6671.147DP (PF08781, IPR014889, SM01138): Transcription factor DP
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
94 TJP2oncoprotein21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
95 TPX2interactor100Aurora-A_bind (PF09041, IPR015128): Aurora-A binding
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259)
TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
96 TRA2Ainteractor110.43622.122DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
97 TRA2Binteractor70.7142.919RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
98 TRAK1interactor100HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Milton (PF12448, IPR022154): Kinesin associated protein
99 UBE2Winteractor40.6670.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
100 UHRF2suppressor110.51114.851PHD (PF00628, IPR019787, SM00249): PHD-finger
SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
101 VGLL4interactor21.0000Vg_Tdu (PF07545, IPR011520): Vestigial/Tondu family
VGLL4 (PF15245, IPR028184): Transcription cofactor vestigial-like protein 4
102 WDR33interactor40.6670.952Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
103 ZEB1interactor21.0000CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
GET2 (PF08690, IPR028143): GET complex subunit GET2
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
104 ZMYM3interactor21.0000NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
YHS (PF04945, IPR007029): YHS domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
105 ZNF101interactor21.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
106 ZNF174interactor41.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
107 ZNF335interactor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
108 ZSCAN1interactor50.6672.000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Tautomerase_2 (PF14552, IPR004370): Tautomerase enzyme

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CBY1interactorChibby (PF14645, IPR028118): Chibby family
2 CDK6parental proteinPkinase (PF00069, IPR000719): Protein kinase domain
3 DAB1interactorPID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
4 DEDD2interactorDED (PF01335, IPR001875, SM00031): Death effector domain
5 HSP90AA5PinteractorNA
6 SSBP2suppressorSSDP (PF04503): Single-stranded DNA binding protein, SSDP
7 UCHL1suppressorPeptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
8 ZFP36suppressorzf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

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