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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BE837730 is the fusion of parental proteins MCM3, CALR (from a repository: Wed Dec 7 17:11:19 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)208
The number (and %) of the onco-proteins73 (35.10 %)
The number (and %) of the tumor suppressors17 (8.17 %)
Total number of binary PPIs (saturation %)2082 (9.67 %)
The number (and %) of affected PPIs207 (9.94 %)
The number of possible different fusions48
PPI diameter2
PPI radius1
The average degree of PPI19.144
Assortativity coefficient-0.1786
The network average Clustering coefficient0.468
The number (and %) of a zero Clustering coefficients4 (1.92 %)
The number (and %) of a zero Betweenness Centrality13 (6.25 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CALR,MCM3 All fusions
: BE837730;
Proteins found in more fusions GRK5 (see 4 fusions); LZTR1 (see 2 fusions); U2AF2 (see 2 fusions); EWSR1 (see 2 fusions); GANAB/PRKCSH (see 1 fusions); HDAC5 (see 1 fusions); EP300 (see 1 fusions); PCNA (see 1 fusions); TPD52L2 (see 2 fusions); RPA1 (see 1 fusions); SUZ12 (see 2 fusions); HSPB1/OBSL1 (see 1 fusions); APP (see 4 fusions); ORC2 (see 2 fusions); VCP (see 4 fusions); TKT (see 5 fusions); HSP90AA1 (see 2 fusions); HUWE1 (see 2 fusions); HSP90AB1 (see 1 fusions); COPS5/HNRNPH3 (see 3 fusions); NTRK1/TPM3 (see 3 fusions); EZR (see 2 fusions); HSPB1 (see 4 fusions); POLR2A (see 2 fusions); CSNK2A1 (see 1 fusions); EPAS1 (see 1 fusions); MIB1 (see 3 fusions); L3MBTL1 (see 1 fusions); HNRNPH3 (see 1 fusions); CUL7 (see 2 fusions); CSNK2A1/ELAVL1 (see 1 fusions); PPME1 (see 1 fusions); CUL3 (see 1 fusions); SMARCB1 (see 12 fusions); COPS5 (see 1 fusions); FN1/YWHAG (see 1 fusions); PAK2 (see 2 fusions); CCND1 (see 1 fusions); MCM7 (see 2 fusions); YWHAG (see 1 fusions); ELF3 (see 2 fusions); NR3C1 (see 8 fusions); TPM3 (see 2 fusions); CD40 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); B2M (see 10 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE837730chimera2070.08423484.041Calreticulin (PF00262, IPR001580): Calreticulin family
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
2 AARSD1interactor130.51319.341tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
3 ACTBL2interactor160.30821.747Actin (PF00022, IPR004000, SM00268): Actin
4 ACTR2interactor250.33774.598Actin (PF00022, IPR004000, SM00268): Actin
5 ANP32Boncoprotein170.39032.175FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
SDA1 (PF05285, IPR007949): SDA1
LRR_9 (PF14580): Leucine-rich repeat
6 APOBinteractor70.6670.977DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
7 APPprotein found in more fusions440.144521.330APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 ARoncoprotein170.30041.621Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
9 ARPC1Ainteractor140.53819.679WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
10 ARPC1Binteractor130.42317.261WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
11 ARPC3interactor160.33334.943P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
12 ARPC5interactor130.44923.215P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
13 ARRB2interactor200.38923.588Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
14 ASF1Binteractor81.0000ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
15 ATF2oncoprotein230.32547.596bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
16 ATP5Binteractor240.42829.304AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
17 B2Moncoprotein70.6005.333C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
18 CALUinteractor350.261237.862EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
19 CANXinteractor410.245372.243Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
20 CAP1interactor170.51715.960CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
21 CCDC8interactor370.325136.037Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
22 CCL2interactor90.7501.454IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
23 CCND1oncoprotein150.40722.349Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
24 CCNE1oncoprotein100.46712.648Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
25 CD1Dinteractor30.6671.000Kelch_2 (PF07646, IPR011498): Kelch motif
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
MHC_I_3 (PF16497, IPR011161): MHC-I family domain
26 CD40protein found in more fusions200Glycophorin_A (PF01102, IPR001195): Glycophorin A
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
27 CDC45interactor160.48320.741CDC45 (PF02724, IPR003874): CDC45-like protein
28 CDC5Linteractor400.362140.643OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
29 CDC6oncoprotein120.56110.439Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
30 CDC7interactor130.6678.738Pkinase (PF00069, IPR000719): Protein kinase domain
31 CDK2suppressor560.203574.367Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
32 CLN5interactor50.8000.348CLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
33 CNTRLoncoprotein80.25016.487APG6 (PF04111, IPR007243): Autophagy protein Apg6
BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
LRR_9 (PF14580): Leucine-rich repeat
34 COPS5protein found in more fusions410.272230.472JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
35 CRY1interactor150.30822.980DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
36 CSNK2A1oncoprotein270.39446.309Pkinase (PF00069, IPR000719): Protein kinase domain
37 CUL2suppressor300.324113.686Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
38 CUL3protein found in more fusions610.224602.490Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
39 CUL7protein found in more fusions510.247314.595ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
40 DBF4interactor110.8891.044BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
41 DCTN1interactor70.4676.222Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
42 DCUN1D1interactor160.51710.632Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
43 EEF2interactor320.274153.269EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
44 EEF2Kinteractor60.5332.869Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
45 EGFRoncoprotein450.242312.720Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
46 ELAVL1oncoprotein540.197604.446RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
47 ELF3oncoprotein60.6001.869AT_hook (PF02178, IPR017956, SM00384): AT hook motif
Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
48 ENO1oncoprotein370.305177.149Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
49 ENO2interactor140.52722.219Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
50 ENO3interactor70.6193.219Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
51 ENSAinteractor21.0000Endosulfine (PF04667, IPR006760): cAMP-regulated phosphoprotein/endosulfine conserved region
52 EP300oncoprotein270.255128.817Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
53 EPAS1suppressor100.36110.203Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
54 EPB41suppressor60.4673.9744_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
SAB (PF04382, IPR007477): SAB domain
55 EWSR1oncoprotein440.292234.723RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
56 EZRprotein found in more fusions230.42438.942DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
57 F5interactor31.0000Cu-oxidase_2 (PF07731, IPR011706): Multicopper oxidase
Cu-oxidase_3 (PF07732, IPR011707): Multicopper oxidase
LSPR (PF06049, IPR009271): Coagulation Factor V LSPD Repeat
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
DUF4672 (PF15716, IPR031445): Domain of unknown function (DUF4672)
58 F8interactor40.6671.667Cu-oxidase (PF00394, IPR001117): Multicopper oxidase
Cu-oxidase_2 (PF07731, IPR011706): Multicopper oxidase
Cu-oxidase_3 (PF07732, IPR011707): Multicopper oxidase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
59 FAM188Asuppressor30.6670.133DUF4205 (PF13898, IPR025257): Domain of unknown function (DUF4205)
60 FBXO25suppressor110.29111.751Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
61 FBXO6interactor370.246221.175FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
62 FGBinteractor21.0000Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
63 FKBP4interactor190.45630.270FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
64 FKBP5interactor140.45119.503FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NuDC (PF16273, IPR032572): Nuclear distribution C domain
65 FN1oncoprotein480.245344.925fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
66 GANABsuppressor240.36667.966Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
DUF5110 (PF17137): Domain of unknown function (DUF5110)
67 GINS4interactor70.3816.897Sld5 (PF05916, IPR021151): GINS complex protein
SLD5_C (PF16922, IPR031633): DNA replication complex GINS protein SLD5 C-terminus
68 GRK5protein found in more fusions90.4295.979Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
69 H2AFXsuppressor260.33251.789Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
70 HDAC5protein found in more fusions280.38739.736Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
71 HIF1Asuppressor140.52711.720Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
72 HIST1H3Einteractor140.65912.665Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
73 HIST1H4Ainteractor270.39351.898CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
74 HLA-Aoncoprotein110.36421.888DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
75 HLA-Einteractor31.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
76 HNRNPFinteractor350.32993.148RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
77 HNRNPH2interactor200.46217.392RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
78 HNRNPH3protein found in more fusions250.47831.183Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
79 HNRNPUinteractor410.309184.909CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
80 HSP90AA1oncoprotein510.267343.616HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
81 HSP90AB1oncoprotein490.309255.181HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
82 HSP90B1suppressor380.333167.396CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
83 HSPB1oncoprotein380.345179.994HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
84 HUWE1oncoprotein340.40382.052BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
85 ILF2interactor380.384112.163DZF (PF07528, IPR006561, SM00572): DZF domain
86 ITGA3interactor30.6670.333FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
MLANA (PF14991, IPR029242): Protein melan-A
87 ITGA4interactor330.35987.098FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
88 KCNH2interactor50.8000.282Ion_trans (PF00520, IPR005821): Ion transport protein
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
PAS_9 (PF13426, IPR000014): PAS domain
89 KEAP1oncoprotein90.6073.943BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
90 KMT2Einteractor60.5332.712CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
91 KRASoncoprotein140.29529.904Ras (PF00071, IPR001806, SM00173): Ras family
92 KRT17interactor50.7000.311DUF1798 (PF08807, IPR014913): Bacterial domain of unknown function (DUF1798)
Filament (PF00038, IPR001664): Intermediate filament protein
93 L3MBTL1protein found in more fusions100.6941.670MBT (PF02820, IPR004092, SM00561): mbt repeat
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
94 LGR4interactor100.27811.9267tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
95 LPLinteractor60.6001.936Lipase (PF00151, IPR013818): Lipase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
96 LPPoncoprotein120.30321.538LIM (PF00412, IPR001781, SM00132): LIM domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
97 LRIF1interactor50.6670.686LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
98 LRP1interactor90.44414.556EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
TadE (PF07811, IPR012495): TadE-like protein
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
99 LZTR1oncoprotein31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
100 MAPK6oncoprotein100.27810.591Pkinase (PF00069, IPR000719): Protein kinase domain
101 MAPRE3interactor30.6671.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
102 MATR3interactor290.41054.067DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
103 MBL2interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
104 MCFD2interactor60.6672.611EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
105 MCM10interactor150.59011.607Mcm10 (PF09332, IPR015411): Mcm10 replication factor
zf-primase (PF09329, IPR015408): Primase zinc finger
AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
106 MCM2oncoprotein750.234863.483AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
107 MCM3APinteractor30.6670.250RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAC3_GANP (PF03399, IPR005062): SAC3/GANP family
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
CID_GANP (PF16766, IPR031910): Binding region of GANP to ENY2
NupH_GANP (PF16768, IPR031908): Nucleoporin homology of Germinal-centre associated nuclear protein
MCM3AP_GANP (PF16769, IPR031907): MCM3AP domain of GANP
108 MCM4interactor410.336171.303MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
109 MCM5oncoprotein470.274338.941MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
110 MCM6interactor370.379116.970MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
111 MCM7protein found in more fusions540.245473.924MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
112 MCMBPinteractor110.6737.008MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
113 MGEA5oncoprotein80.7501.561NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
114 MGMTinteractor120.5159.931DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
115 MIB1protein found in more fusions50.6671.500Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
116 MSNoncoprotein210.48424.219DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
117 MTNR1Ainteractor30.6670.4007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
118 NACA2interactor80.7141.662NAC (PF01849, IPR002715): NAC domain
119 NCAPD3interactor50.5003.056DUF3013 (PF11217, IPR021380): Protein of unknown function (DUF3013)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
120 NKX2-1oncoprotein100DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719)
121 NOTCH1suppressor90.4644.332Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
122 NR3C1protein found in more fusions120.36416.902GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
123 NSUN2interactor210.26775.402Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
124 NTMinteractor31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain
Ig_3 (PF13927): Immunoglobulin domain
125 NTRK1oncoprotein860.1841462.910I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
126 NUP62interactor80.6192.794Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
127 NUP88interactor80.4294.419Nup88 (PF10168, IPR019321): Nuclear pore component
128 OBSL1protein found in more fusions440.286183.450BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
129 ORC2protein found in more fusions200.59618.830ORC2 (PF04084, IPR007220): Origin recognition complex subunit 2
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
130 ORC4interactor160.51720.161AAA_16 (PF13191): AAA ATPase domain
ORC4_C (PF14629, IPR032705): Origin recognition complex (ORC) subunit 4 C-terminus
131 ORC5interactor150.59310.853AAA_16 (PF13191): AAA ATPase domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
132 P4HBinteractor450.320229.852Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
133 PAK2protein found in more fusions110.4228.431PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
134 PARK2suppressor260.29064.102IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
135 PCNAoncoprotein460.251334.099PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
136 PDIA3interactor240.261112.247Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
137 PFDN5interactor60.6671.968Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
138 PLATinteractor30.6670.667EGF (PF00008, IPR000742, SM00181): EGF-like domain
fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
Kringle (PF00051, IPR000001): Kringle domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
139 PLP1interactor100Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
140 PMS2oncoprotein40.5001.686DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
MORN_2 (PF07661, IPR011652): MORN repeat variant
MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
141 PNKPinteractor100.5783.696PNK3P (PF08645, IPR013954): Polynucleotide kinase 3 phosphatase
AAA_33 (PF13671): AAA domain
142 POLA1interactor170.34643.577DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-DNA_Pol (PF08996, IPR015088): DNA Polymerase alpha zinc finger
DNA_pol_alpha_N (PF12254, IPR024647): DNA polymerase alpha subunit p180 N terminal
143 POLD1interactor170.37541.215DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
144 POLD3interactor50.6001.089CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
145 POLR2Aprotein found in more fusions270.35785.601RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
146 POLR2Dinteractor60.5334.040RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
Tfb4 (PF03850, IPR004600): Transcription factor Tfb4
147 PPATinteractor30.6670.167Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
148 PPME1protein found in more fusions170.34226.118Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
149 PPP2R1Aoncoprotein270.31386.926TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
150 PPP2R1Bsuppressor90.42910.101HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
151 PRF1oncoprotein31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
152 PRKACAinteractor150.40036.882Pkinase (PF00069, IPR000719): Protein kinase domain
153 PRKCSHprotein found in more fusions130.53815.914CDC45 (PF02724, IPR003874): CDC45-like protein
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
EF-hand_5 (PF13202, IPR002048): EF hand
154 PSMA3interactor250.45343.101Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
155 PSMD5interactor80.3937.784Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
156 PTGES3interactor230.36870.044CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
157 PTP4A3oncoprotein40.6670.315DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
158 PUS7interactor110.40018.261R3H (PF01424, IPR001374, SM00393): R3H domain
TruD (PF01142, IPR001656): tRNA pseudouridine synthase D (TruD)
159 RAD21oncoprotein220.40739.831Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
160 RCN1interactor200.38443.703EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
161 RDXinteractor150.48614.546ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
162 RFC3interactor140.6265.421CHB_HEX (PF03173, IPR004866, SM01081): Putative carbohydrate binding domain
DNA_pol3_delta (PF06144, IPR010372): DNA polymerase III, delta subunit
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
DNA_pol3_delta2 (PF13177): DNA polymerase III, delta subunit
163 RFC4interactor160.60812.577AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
164 RNF2interactor340.250145.101zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
165 RPA1suppressor450.317252.993Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
166 RPA2oncoprotein400.296226.579RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
167 RPA3interactor270.41860.851Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
168 RPS6KB2interactor140.29722.726Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
169 SAE1interactor90.4178.055ThiF (PF00899, IPR000594): ThiF family
170 SENP3interactor220.37252.563Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
171 SH3GL1oncoprotein150.53818.332BAR (PF03114, IPR004148, SM00721): BAR domain
PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
172 SH3GLB1suppressor150.48421.078BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
173 SIRT7interactor320.264128.670DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
174 SLC27A2interactor30.6670.400AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
175 SLC2A1interactor60.6002.590Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
176 SLC6A4interactor21.00005HT_transport_N (PF03491, IPR013086): Serotonin (5-HT) neurotransmitter transporter, N-terminus
SNF (PF00209, IPR000175): Sodium:neurotransmitter symporter family
177 SMARCA5interactor190.43827.013HAND (PF09110, IPR015194): HAND
SLIDE (PF09111, IPR015195): SLIDE
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DBINO (PF13892, IPR020838): DNA-binding domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
178 SMARCB1suppressor90.3938.671SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
179 SOX2oncoprotein90.2868.908HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
180 SSRP1interactor230.45136.941Rtt106 (PF08512, IPR013719): Histone chaperone Rttp106-like
SSrecog (PF03531, IPR024954): Structure-specific recognition protein (SSRP1)
YABBY (PF04690, IPR006780): YABBY protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
CAML (PF14963, IPR016719): Calcium signal-modulating cyclophilin ligand
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
Coilin_N (PF15862, IPR031722): Coilin N-terminus
181 SUZ12suppressor180.40423.715DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
182 SYF2interactor30.6670.167SYF2 (PF08231, IPR013260): SYF2 splicing factor
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
183 TAP1oncoprotein70.6194.971ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
184 TAPBPinteractor60.6003.152C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
185 TCEA1oncoprotein50.8000.417Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
186 TCTN1interactor90.6672.573DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
187 TCTN3interactor130.46216.864DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
188 THG1Linteractor100.7224.305Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
189 TIPINinteractor60.7331.500ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Swi3 (PF07962, IPR012923): Replication Fork Protection Component Swi3
CEP19 (PF14933, IPR029412): CEP19-like protein
190 TJP2oncoprotein90.33313.316PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
191 TKTprotein found in more fusions240.45841.262Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
192 TONSLinteractor120.8182.406LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
193 TPD52L2protein found in more fusions180.35337.111TPD52 (PF04201, IPR007327): Tumour protein D52 family
194 TPM3oncoprotein210.46322.406Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
195 TPT1interactor40.5000.527TCTP (PF00838, IPR018105): Translationally controlled tumour protein
196 TRIM21interactor80.6192.383DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
197 TSHRoncoprotein30.6670.1677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
198 U2AF2protein found in more fusions370.40590.304RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
199 UBE3Aoncoprotein150.35226.382HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
200 UPF2interactor70.5332.815DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
201 VCAM1interactor330.32490.851C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
202 VCPprotein found in more fusions560.265465.711AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
203 VWFinteractor30.6670.667Antistasin (PF02822, IPR004094): Antistasin family
C8 (PF08742, IPR014853, SM00832): C8 domain
Metallothio_5 (PF02067, IPR000966): Metallothionein family 5
Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII)
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
VWA_N2 (PF16164, IPR032361): VWA N-terminal
204 WDR1interactor120.6528.395eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
205 WRAP73interactor50.6671.500eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
IKI3 (PF04762, IPR006849): IKI3 family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2555 (PF10742, IPR019678): Protein of unknown function (DUF2555)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
206 YWHAEoncoprotein340.360123.99914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
207 YWHAGprotein found in more fusions270.36965.98214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
208 YWHAQinteractor360.300185.78014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CALRparental proteinCalreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
2 INHAoncoproteinTGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
3 MCM3parental proteinMCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
4 PIPSLinteractorNA
5 RNY1interactorNA
6 RNY3interactorNA
7 RNY4interactorNA
8 SNCGoncoproteinSynuclein (PF01387, IPR001058): Synuclein
9 TFinteractorTransferrin (PF00405, IPR001156, SM00094): Transferrin

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