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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BE837418 is the fusion of parental proteins RBM47, EPC1 (from a repository: Thu Feb 8 21:37:29 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins4 (14.81 %)
The number (and %) of the tumor suppressors8 (29.63 %)
Total number of binary PPIs (saturation %)127 (36.18 %)
The number (and %) of affected PPIs26 (20.47 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI8.741
Assortativity coefficient-0.3800
The network average Clustering coefficient0.715
The number (and %) of a zero Clustering coefficients3 (11.11 %)
The number (and %) of a zero Betweenness Centrality10 (37.04 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: RBM47,EPC1 All fusions
: BE837418;
Proteins found in more fusions KAT5 (see 3 fusions); EZH2 (see 1 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE837418chimera260.283318.156DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
E_Pc_C (PF06752, IPR009607): Enhancer of Polycomb C-terminus
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
2 ATMsuppressor31.0000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
3 DMAP1interactor160.65022.390DMAP1 (PF05499, IPR008468): DNA methyltransferase 1-associated protein 1 (DMAP1)
SANT_DAMP1_like (PF16282, IPR032563): SANT/Myb-like domain of DAMP1
4 E2F6oncoprotein40.8330.667BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
5 EEDsuppressor60.6003.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6 EZH2suppressor41.0000CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
7 FOXO6suppressor61.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
8 FOXR1interactor100.8891.343Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
9 FOXR2interactor110.8183.276Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
10 H2AFZinteractor91.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
11 HIST1H2BAinteractor100.9560.450Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12 HOPXsuppressor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
13 ING3suppressor120.8642.144PHD (PF00628, IPR019787, SM00249): PHD-finger
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
14 KAT5suppressor200.49161.490MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
15 KRT15interactor100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
16 MED23interactor51.0000Med23 (PF11573, IPR021629): Mediator complex subunit 23
17 MORF4L1interactor140.8462.880MRG (PF05712, IPR026541): MRG
Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
18 MORF4L2interactor100.9330.644MRG (PF05712, IPR026541): MRG
19 MRGBPinteractor140.7696.480Eaf7 (PF07904, IPR012423): Chromatin modification-related protein EAF7
20 MYConcoprotein90.8930.933HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
21 PLAC1interactor81.0000Paired_CXXCH_1 (PF09699, IPR010177): Doubled CXXCH motif (Paired_CXXCH_1)
22 RINT1suppressor100RINT1_TIP1 (PF04437, IPR007528): RINT-1 / TIP-1 family
23 RNF2interactor60.5004.333zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
24 SRFinteractor31.0000SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
25 TRIM27oncoprotein40.6670.667IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
26 TRRAPinteractor160.64222.990BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
27 YEATS4interactor160.67513.823YEATS (PF03366, IPR005033): YEATS family
SOGA (PF11365, IPR027881): Protein SOGA

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 C1orf94interactorDUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
2 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
3 EPC1parental proteinE_Pc_C (PF06752, IPR009607): Enhancer of Polycomb C-terminus
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
4 HSFY1interactorHSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
5 RBM47parental proteinRibosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

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