Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	139
The number (and %) of the onco-proteins	42 (30.22 %)
The number (and %) of the tumor suppressors	22 (15.83 %)
Total number of binary PPIs (saturation %)	774 (8.07 %)
The number (and %) of affected PPIs	138 (17.83 %)
The number of possible different fusions	25
PPI diameter	2
PPI radius	1
The average degree of PPI	10.374
Assortativity coefficient	-0.3103
The network average Clustering coefficient	0.520
The number (and %) of a zero Clustering coefficients	9 (6.47 %)
The number (and %) of a zero Betweenness Centrality	32 (23.02 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MTOR	All fusions : BE830802;
Proteins found in more fusions	TRAF6 (see 1 fusions); ILK (see 1 fusions); VCP (see 4 fusions); GSK3B (see 1 fusions); PRKCD (see 2 fusions); SQSTM1 (see 5 fusions); SGK1 (see 2 fusions); PRKAR1A (see 2 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); UBQLN1 (see 2 fusions); FKBP8 (see 1 fusions); BCL2L1 (see 1 fusions); ULK1 (see 2 fusions); YWHAZ (see 1 fusions); EGFR (see 2 fusions); IKBKB (see 2 fusions); CDC37 (see 2 fusions); DDB1 (see 2 fusions); PML (see 4 fusions); RPTOR (see 3 fusions); STAT1 (see 1 fusions); TP53 (see 3 fusions); SUZ12 (see 2 fusions);

List of the fusions

PPI for parental proteins: MTOR

All fusions

: BE830802;

Proteins found in more fusions

TRAF6 (see 1 fusions); ILK (see 1 fusions); VCP (see 4 fusions); GSK3B (see 1 fusions); PRKCD (see 2 fusions); SQSTM1 (see 5 fusions); SGK1 (see 2 fusions); PRKAR1A (see 2 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); UBQLN1 (see 2 fusions); FKBP8 (see 1 fusions); BCL2L1 (see 1 fusions); ULK1 (see 2 fusions); YWHAZ (see 1 fusions); EGFR (see 2 fusions); IKBKB (see 2 fusions); CDC37 (see 2 fusions); DDB1 (see 2 fusions); PML (see 4 fusions); RPTOR (see 3 fusions); STAT1 (see 1 fusions); TP53 (see 3 fusions); SUZ12 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	BE830802	chimera	138	0.062	13151.032	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
2	ABL1	oncoprotein	15	0.396	27.882	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	AKT1	oncoprotein	28	0.276	135.639	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4	AKT1S1	interactor	9	0.679	2.392	Pap_E4 (PF02711, IPR003861): E4 protein PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
5	AMBRA1	interactor	6	0.733	1.750	Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Spt20 (PF12090, IPR021950): Spt20 family ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6	ASPM	oncoprotein	3	0.667	0.333	CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RST (PF12174, IPR022003): RCD1-SRO-TAF4 (RST) plant domain ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
7	BAG6	interactor	8	0.286	12.633	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
8	BCL2L1	oncoprotein	9	0.464	6.256	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
9	BRAT1	oncoprotein	6	0.400	5.915	HEAT (PF02985, IPR000357): HEAT repeat HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
10	BRCA1	suppressor	22	0.238	104.690	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
11	BSG	interactor	4	0.667	1.667	Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
12	C7orf25	interactor	1	0	0	DUF1308 (PF07000, IPR010733): Protein of unknown function (DUF1308) DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
13	CA14	interactor	1	0	0	Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase NicO (PF03824, IPR011541): High-affinity nickel-transport protein
14	CD244	interactor	1	0	0	Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4 WBP-1 (PF11669, IPR021684): WW domain-binding protein 1 Ig_2 (PF13895, IPR007110): Immunoglobulin domain
15	CD274	oncoprotein	2	1.000	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E V-set (PF07686, IPR013106): Immunoglobulin V-set domain
16	CDC37	protein found in more fusions	18	0.294	42.271	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
17	CFP	oncoprotein	1	0	0	TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
18	CHUK	suppressor	18	0.434	28.940	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
19	CLIP1	oncoprotein	1	0	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain CP12 (PF02672, IPR003823, SM01093): CP12 domain DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) FliJ (PF02050, IPR012823): Flagellar FliJ protein Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain SlyX (PF04102, IPR007236): SlyX ApoO (PF09769, IPR019166): Apolipoprotein O Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Leu_zip (PF15294): Leucine zipper CLIP1_ZNF (PF16641, IPR032108): CLIP1 zinc knuckle PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
20	DCP2	interactor	2	1.000	0	DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain NUDIX (PF00293, IPR000086): NUDIX domain
21	DDB1	protein found in more fusions	15	0.341	28.775	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
22	DEPTOR	interactor	8	0.750	2.686	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_2 (PF13180, IPR001478): PDZ domain Complex1_LYR_2 (PF13233): Complex1_LYR-like Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
23	DIAPH1	interactor	1	0	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Drf_DAD (PF06345, IPR010465): DRF Autoregulatory Domain Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1 Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain Glucan_synthase (PF02364, IPR003440): 1,3-beta-glucan synthase component Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
24	EGFR	oncoprotein	33	0.175	269.216	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25	EIF3B	interactor	10	0.444	14.821	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
26	EIF3C	oncoprotein	6	0.800	1.233	eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI (PF01399, IPR000717, SM00088): PCI domain
27	EIF3F	suppressor	6	0.667	2.600	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
28	EIF4E	oncoprotein	8	0.500	10.033	IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
29	EIF4EBP1	oncoprotein	10	0.311	22.058	eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
30	EIF4EBP2	interactor	3	1.000	0	eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
31	FBXW7	suppressor	9	0.357	10.412	Mem_trans (PF03547, IPR004776): Membrane transport protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 F-box-like (PF12937, IPR001810): F-box-like
32	FKBP1A	interactor	4	0.667	0.667	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
33	FKBP8	protein found in more fusions	9	0.393	9.141	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
34	GADD45A	suppressor	6	0.600	2.389	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
35	GNB1	interactor	8	0.500	9.067	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
36	GNB2	interactor	10	0.467	14.287	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat CALM_bind (PF16025): Calcium-dependent calmodulin binding WD40_like (PF17005, IPR031544): WD40-like domain
37	GNB3	interactor	2	1.000	0	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
38	GNB5	interactor	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
39	GNG2	interactor	7	0.429	10.567	G-gamma (PF00631, IPR015898, SM00224): GGL domain SidE (PF12252, IPR021014): Dot/Icm substrate protein
40	GPHN	oncoprotein	3	1.000	0	MoCF_biosynth (PF00994, IPR001453, SM00852): Probable molybdopterin binding domain MoeA_C (PF03454, IPR005111): MoeA C-terminal region (domain IV) MoeA_N (PF03453, IPR005110): MoeA N-terminal region (domain I and II) Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
41	GSK3B	suppressor	15	0.308	36.327	Pkinase (PF00069, IPR000719): Protein kinase domain
42	GTF3C1	interactor	5	0.500	2.737	B-block_TFIIIC (PF04182, IPR007309): B-block binding subunit of TFIIIC
43	HNRNPD	oncoprotein	10	0.361	14.093	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
44	HSPA4	interactor	31	0.241	204.434	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
45	HTR6	interactor	4	0.667	1.167	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
46	IKBKB	protein found in more fusions	16	0.486	19.510	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
47	IKBKG	interactor	18	0.463	29.486	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
48	ILK	suppressor	11	0.400	14.067	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
49	IRS1	interactor	11	0.545	8.605	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
50	LAMTOR2	interactor	5	1.000	0	Robl_LC7 (PF03259, IPR004942, SM00960): Roadblock/LC7 domain
51	LARS	interactor	4	0.667	1.286	Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
52	LLGL2	interactor	4	0.667	1.000	Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
53	LRPAP1	interactor	2	1.000	0	Alpha-2-MRAP_C (PF06401, IPR010483): Alpha-2-macroglobulin RAP, C-terminal domain Alpha-2-MRAP_N (PF06400, IPR009066): Alpha-2-macroglobulin RAP, N-terminal domain
54	LYPD3	oncoprotein	2	1.000	0	DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753) UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
55	MAF1	interactor	2	0	0	Maf1 (PF09174, IPR015257): Maf1 regulator
56	MAP3K3	oncoprotein	10	0.528	4.700	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
57	MAPK8	oncoprotein	14	0.462	17.870	DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain
58	MAPKAP1	interactor	14	0.374	31.030	SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1) CRIM (PF16978, IPR031567): SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH (PF16979, IPR031313): SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
59	METAP2	oncoprotein	3	0.667	0.667	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
60	MLST8	interactor	15	0.352	42.181	Hira (PF07569, IPR011494): TUP1-like enhancer of split WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
61	MLXIP	interactor	2	1.000	0	ZapB (PF06005, IPR009252): Cell division protein ZapB HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Stm1_N (PF09598, IPR019084): Stm1 Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
62	MLXIPL	interactor	2	1.000	0	ZapB (PF06005, IPR009252): Cell division protein ZapB HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
63	MOV10	interactor	16	0.250	44.087	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
64	MTA2	interactor	6	0.533	5.133	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
65	MTMR3	oncoprotein	3	1.000	0	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
66	NAF1	interactor	3	0.667	0.667	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
67	NBN	suppressor	7	0.667	2.850	FHA (PF00498, IPR000253, SM00240): FHA domain Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1 NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
68	NCBP1	interactor	9	0.333	17.400	MIF4G (PF02854, IPR003890, SM00543): MIF4G domain MIF4G_like (PF09088, IPR015172): MIF4G like MIF4G_like_2 (PF09090, IPR015174): MIF4G like SlyX (PF04102, IPR007236): SlyX
69	NFKBIA	oncoprotein	10	0.489	8.955	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
70	NT5E	interactor	2	1.000	0	5_nucleotid_C (PF02872, IPR008334): 5'-nucleotidase, C-terminal domain Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
71	NXF1	interactor	22	0.243	88.274	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
72	PA2G4	interactor	9	0.444	9.140	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein TraC (PF07820, IPR012930): TraC-like protein
73	PARK2	suppressor	20	0.251	82.072	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
74	PDIA3	interactor	8	0.429	9.675	Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
75	PDK1	interactor	6	0.600	1.119	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
76	PLD2	interactor	7	0.524	2.952	PH (PF00169, IPR001849, SM00233): PH domain PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif PX (PF00787, IPR001683, SM00312): PX domain PLDc_2 (PF13091, IPR025202): PLD-like domain
77	PML	suppressor	13	0.333	26.247	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
78	PPP2R2A	interactor	5	0.600	1.500	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
79	PREX1	oncoprotein	4	1.000	0	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
80	PREX2	interactor	1	0	0	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
81	PRKAA1	suppressor	10	0.422	12.998	Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
82	PRKAR1A	suppressor	6	0.700	1.100	RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
83	PRKCA	interactor	14	0.308	23.617	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
84	PRKCD	suppressor	13	0.394	16.279	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
85	PRR5	suppressor	5	0.800	0.900	HbrB (PF08539, IPR013745): HbrB-like
86	PRR5L	interactor	3	1.000	0	HbrB (PF08539, IPR013745): HbrB-like
87	RAB1A	oncoprotein	5	0.600	3.000	Ras (PF00071, IPR001806, SM00173): Ras family
88	RAP1A	suppressor	6	0.400	5.467	Ras (PF00071, IPR001806, SM00173): Ras family
89	RAP2A	oncoprotein	5	0.400	1.929	Ras (PF00071, IPR001806, SM00173): Ras family
90	RHEB	oncoprotein	6	0.467	5.417	Ras (PF00071, IPR001806, SM00173): Ras family
91	RHEBL1	interactor	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
92	RICTOR	interactor	33	0.203	277.464	RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
93	RP2	interactor	2	1.000	0	NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase TBCC (PF07986, IPR012945): Tubulin binding cofactor C
94	RPL23	interactor	11	0.527	11.827	Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
95	RPL23A	interactor	11	0.509	14.697	Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23 Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
96	RPL26	oncoprotein	7	0.810	1.036	TP2 (PF01254, IPR000678): Nuclear transition protein 2 Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
97	RPL5	suppressor	10	0.694	4.978	Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
98	RPS6	interactor	15	0.486	25.942	Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
99	RPS6KB1	interactor	23	0.273	102.894	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
100	RPTOR	protein found in more fusions	54	0.128	949.598	HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
101	RRAGB	interactor	6	0.867	1.000	Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
102	RRAGC	interactor	7	0.762	2.833	Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
103	RRAGD	interactor	6	0.800	2.000	Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
104	RUVBL1	oncoprotein	14	0.423	23.781	TIP49 (PF06068, IPR010339): TIP49 C-terminus
105	RUVBL2	oncoprotein	15	0.385	30.654	TIP49 (PF06068, IPR010339): TIP49 C-terminus
106	SCN2B	interactor	2	1.000	0	DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191) V-set (PF07686, IPR013106): Immunoglobulin V-set domain
107	SEPT2	oncoprotein	3	0.667	0.500	FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger Septin (PF00735, IPR000038): Septin
108	SGK1	oncoprotein	14	0.397	24.022	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain
109	SGTB	interactor	2	1.000	0	TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_11 (PF13414, IPR011990): TPR repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
110	SHMT2	interactor	8	0.286	10.183	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
111	SIRT1	suppressor	14	0.410	25.614	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
112	SIRT7	interactor	17	0.316	55.937	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
113	SQSTM1	oncoprotein	24	0.281	113.170	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
114	STAT1	suppressor	15	0.330	30.635	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
115	STAT3	suppressor	16	0.248	48.471	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
116	STK38	interactor	5	0.667	0.571	MEKHLA (PF08670, IPR013978): MEKHLA domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
117	SUMO1	interactor	7	0.667	1.833	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
118	SUZ12	suppressor	11	0.333	17.086	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
119	SYNCRIP	interactor	5	0.700	1.333	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
120	TELO2	interactor	10	0.511	12.906	Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein HEAT_2 (PF13646): HEAT repeats
121	TERF1	interactor	13	0.333	22.960	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
122	TERT	oncoprotein	12	0.364	19.321	RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
123	TNFAIP3	suppressor	11	0.533	8.367	OTU (PF02338, IPR003323): OTU-like cysteine protease zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
124	TP53	suppressor	33	0.214	249.306	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
125	TRAF2	interactor	13	0.394	24.388	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
126	TRAF6	protein found in more fusions	18	0.382	44.115	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
127	TRMT61A	interactor	1	0	0	GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit GCD14_N (PF14801): tRNA methyltransferase complex GCD14 subunit N-term
128	TTI1	interactor	10	0.378	24.369	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat VHS (PF00790, IPR002014, SM00288): VHS domain CLASP_N (PF12348, IPR024395): CLASP N terminal
129	UBQLN1	protein found in more fusions	5	0.500	1.733	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X
130	ULK1	protein found in more fusions	10	0.528	9.743	Pkinase (PF00069, IPR000719): Protein kinase domain DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
131	USP9X	interactor	9	0.417	9.916	DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722) UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
132	VCP	protein found in more fusions	28	0.208	188.834	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
133	VPS16	interactor	2	1.000	0	Vps16_C (PF04840, IPR006925): Vps16, C-terminal region Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
134	VSIG2	interactor	2	1.000	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
135	XPO1	interactor	41	0.155	520.379	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
136	YEATS4	interactor	4	1.000	0	YEATS (PF03366, IPR005033): YEATS family SOGA (PF11365, IPR027881): Protein SOGA
137	YWHAQ	interactor	12	0.424	14.667	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
138	YWHAZ	protein found in more fusions	23	0.286	81.643	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
139	ZSCAN26	interactor	2	1.000	0	C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain SCAN (PF02023, IPR003309, SM00431): SCAN domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	GDI2P1	interactor	NA
2	MTOR	parental protein	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat

B a c k t o T o p ⇑

Fusion ID: Protein names:	BE830802
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List of the fusions

List of active interactors

List of missing interactors