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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)139
The number (and %) of the onco-proteins42 (30.22 %)
The number (and %) of the tumor suppressors22 (15.83 %)
Total number of binary PPIs (saturation %)774 (8.07 %)
The number (and %) of affected PPIs138 (17.83 %)
The number of possible different fusions25
PPI diameter2
PPI radius1
The average degree of PPI10.374
Assortativity coefficient-0.3103
The network average Clustering coefficient0.520
The number (and %) of a zero Clustering coefficients9 (6.47 %)
The number (and %) of a zero Betweenness Centrality32 (23.02 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MTOR All fusions
: BE830802;
Proteins found in more fusions TRAF6 (see 1 fusions); ILK (see 1 fusions); VCP (see 4 fusions); GSK3B (see 1 fusions); PRKCD (see 2 fusions); SQSTM1 (see 5 fusions); SGK1 (see 2 fusions); PRKAR1A (see 2 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); UBQLN1 (see 2 fusions); FKBP8 (see 1 fusions); BCL2L1 (see 1 fusions); ULK1 (see 2 fusions); YWHAZ (see 1 fusions); EGFR (see 2 fusions); IKBKB (see 2 fusions); CDC37 (see 2 fusions); DDB1 (see 2 fusions); PML (see 4 fusions); RPTOR (see 3 fusions); STAT1 (see 1 fusions); TP53 (see 3 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE830802chimera1380.06213151.032DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
2 ABL1oncoprotein150.39627.882Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 AKT1oncoprotein280.276135.639PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 AKT1S1interactor90.6792.392Pap_E4 (PF02711, IPR003861): E4 protein
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
5 AMBRA1interactor60.7331.750Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Spt20 (PF12090, IPR021950): Spt20 family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6 ASPMoncoprotein30.6670.333CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RST (PF12174, IPR022003): RCD1-SRO-TAF4 (RST) plant domain
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
7 BAG6interactor80.28612.633DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 BCL2L1oncoprotein90.4646.256Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
9 BRAT1oncoprotein60.4005.915HEAT (PF02985, IPR000357): HEAT repeat
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
10 BRCA1suppressor220.238104.690BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
11 BSGinteractor40.6671.667Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
12 C7orf25interactor100DUF1308 (PF07000, IPR010733): Protein of unknown function (DUF1308)
DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
13 CA14interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
NicO (PF03824, IPR011541): High-affinity nickel-transport protein
14 CD244interactor100Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
15 CD274oncoprotein21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
16 CDC37protein found in more fusions180.29442.271CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
17 CFPoncoprotein100TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
18 CHUKsuppressor180.43428.940Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
19 CLIP1oncoprotein100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
CP12 (PF02672, IPR003823, SM01093): CP12 domain
DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
SlyX (PF04102, IPR007236): SlyX
ApoO (PF09769, IPR019166): Apolipoprotein O
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Leu_zip (PF15294): Leucine zipper
CLIP1_ZNF (PF16641, IPR032108): CLIP1 zinc knuckle
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
20 DCP2interactor21.0000DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
21 DDB1protein found in more fusions150.34128.775CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
22 DEPTORinteractor80.7502.686DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PDZ_2 (PF13180, IPR001478): PDZ domain
Complex1_LYR_2 (PF13233): Complex1_LYR-like
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
23 DIAPH1interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Drf_DAD (PF06345, IPR010465): DRF Autoregulatory Domain
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Glucan_synthase (PF02364, IPR003440): 1,3-beta-glucan synthase component
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
24 EGFRoncoprotein330.175269.216Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25 EIF3Binteractor100.44414.821eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
26 EIF3Concoprotein60.8001.233eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
27 EIF3Fsuppressor60.6672.600JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
28 EIF4Eoncoprotein80.50010.033IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
29 EIF4EBP1oncoprotein100.31122.058eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
30 EIF4EBP2interactor31.0000eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
31 FBXW7suppressor90.35710.412Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
32 FKBP1Ainteractor40.6670.667FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
33 FKBP8protein found in more fusions90.3939.141FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
34 GADD45Asuppressor60.6002.389Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
35 GNB1interactor80.5009.067Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
36 GNB2interactor100.46714.287WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
37 GNB3interactor21.0000Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
38 GNB5interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
39 GNG2interactor70.42910.567G-gamma (PF00631, IPR015898, SM00224): GGL domain
SidE (PF12252, IPR021014): Dot/Icm substrate protein
40 GPHNoncoprotein31.0000MoCF_biosynth (PF00994, IPR001453, SM00852): Probable molybdopterin binding domain
MoeA_C (PF03454, IPR005111): MoeA C-terminal region (domain IV)
MoeA_N (PF03453, IPR005110): MoeA N-terminal region (domain I and II)
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
41 GSK3Bsuppressor150.30836.327Pkinase (PF00069, IPR000719): Protein kinase domain
42 GTF3C1interactor50.5002.737B-block_TFIIIC (PF04182, IPR007309): B-block binding subunit of TFIIIC
43 HNRNPDoncoprotein100.36114.093CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
44 HSPA4interactor310.241204.434Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
45 HTR6interactor40.6671.1677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
46 IKBKBprotein found in more fusions160.48619.510FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
47 IKBKGinteractor180.46329.486CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
48 ILKsuppressor110.40014.067Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
49 IRS1interactor110.5458.605CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
50 LAMTOR2interactor51.0000Robl_LC7 (PF03259, IPR004942, SM00960): Roadblock/LC7 domain
51 LARSinteractor40.6671.286Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
52 LLGL2interactor40.6671.000Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
53 LRPAP1interactor21.0000Alpha-2-MRAP_C (PF06401, IPR010483): Alpha-2-macroglobulin RAP, C-terminal domain
Alpha-2-MRAP_N (PF06400, IPR009066): Alpha-2-macroglobulin RAP, N-terminal domain
54 LYPD3oncoprotein21.0000DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
55 MAF1interactor200Maf1 (PF09174, IPR015257): Maf1 regulator
56 MAP3K3oncoprotein100.5284.700PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
57 MAPK8oncoprotein140.46217.870DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
58 MAPKAP1interactor140.37431.030SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1)
CRIM (PF16978, IPR031567): SAPK-interacting protein 1 (Sin1), middle CRIM domain
SIN1_PH (PF16979, IPR031313): SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
59 METAP2oncoprotein30.6670.667Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
60 MLST8interactor150.35242.181Hira (PF07569, IPR011494): TUP1-like enhancer of split
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
61 MLXIPinteractor21.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Stm1_N (PF09598, IPR019084): Stm1
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
62 MLXIPLinteractor21.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
63 MOV10interactor160.25044.087AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
64 MTA2interactor60.5335.133BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
65 MTMR3oncoprotein31.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
66 NAF1interactor30.6670.667AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
67 NBNsuppressor70.6672.850FHA (PF00498, IPR000253, SM00240): FHA domain
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
68 NCBP1interactor90.33317.400MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
69 NFKBIAoncoprotein100.4898.955Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
70 NT5Einteractor21.00005_nucleotid_C (PF02872, IPR008334): 5'-nucleotidase, C-terminal domain
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
71 NXF1interactor220.24388.274NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
72 PA2G4interactor90.4449.140Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
73 PARK2suppressor200.25182.072IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
74 PDIA3interactor80.4299.675Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
75 PDK1interactor60.6001.119HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
76 PLD2interactor70.5242.952PH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
77 PMLsuppressor130.33326.247zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
78 PPP2R2Ainteractor50.6001.500WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
79 PREX1oncoprotein41.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
80 PREX2interactor100DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
81 PRKAA1suppressor100.42212.998Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
82 PRKAR1Asuppressor60.7001.100RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
83 PRKCAinteractor140.30823.617C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
84 PRKCDsuppressor130.39416.279Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
85 PRR5suppressor50.8000.900HbrB (PF08539, IPR013745): HbrB-like
86 PRR5Linteractor31.0000HbrB (PF08539, IPR013745): HbrB-like
87 RAB1Aoncoprotein50.6003.000Ras (PF00071, IPR001806, SM00173): Ras family
88 RAP1Asuppressor60.4005.467Ras (PF00071, IPR001806, SM00173): Ras family
89 RAP2Aoncoprotein50.4001.929Ras (PF00071, IPR001806, SM00173): Ras family
90 RHEBoncoprotein60.4675.417Ras (PF00071, IPR001806, SM00173): Ras family
91 RHEBL1interactor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
92 RICTORinteractor330.203277.464RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
93 RP2interactor21.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
TBCC (PF07986, IPR012945): Tubulin binding cofactor C
94 RPL23interactor110.52711.827Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
95 RPL23Ainteractor110.50914.697Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
96 RPL26oncoprotein70.8101.036TP2 (PF01254, IPR000678): Nuclear transition protein 2
Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
97 RPL5suppressor100.6944.978Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
98 RPS6interactor150.48625.942Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
99 RPS6KB1interactor230.273102.894Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
100 RPTORprotein found in more fusions540.128949.598HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
101 RRAGBinteractor60.8671.000Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
102 RRAGCinteractor70.7622.833Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
103 RRAGDinteractor60.8002.000Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
104 RUVBL1oncoprotein140.42323.781TIP49 (PF06068, IPR010339): TIP49 C-terminus
105 RUVBL2oncoprotein150.38530.654TIP49 (PF06068, IPR010339): TIP49 C-terminus
106 SCN2Binteractor21.0000DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
107 SEPT2oncoprotein30.6670.500FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
108 SGK1oncoprotein140.39724.022Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
109 SGTBinteractor21.0000TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_11 (PF13414, IPR011990): TPR repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
110 SHMT2interactor80.28610.183SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
111 SIRT1suppressor140.41025.614DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
112 SIRT7interactor170.31655.937DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
113 SQSTM1oncoprotein240.281113.170PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
114 STAT1suppressor150.33030.635SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
115 STAT3suppressor160.24848.471SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
116 STK38interactor50.6670.571MEKHLA (PF08670, IPR013978): MEKHLA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
117 SUMO1interactor70.6671.833Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
118 SUZ12suppressor110.33317.086DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
119 SYNCRIPinteractor50.7001.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
120 TELO2interactor100.51112.906Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein
HEAT_2 (PF13646): HEAT repeats
121 TERF1interactor130.33322.960TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
122 TERToncoprotein120.36419.321RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase)
Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
123 TNFAIP3suppressor110.5338.367OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
124 TP53suppressor330.214249.306DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
125 TRAF2interactor130.39424.388MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
126 TRAF6protein found in more fusions180.38244.115SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
127 TRMT61Ainteractor100GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit
GCD14_N (PF14801): tRNA methyltransferase complex GCD14 subunit N-term
128 TTI1interactor100.37824.369Dopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
VHS (PF00790, IPR002014, SM00288): VHS domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
129 UBQLN1protein found in more fusions50.5001.733Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
130 ULK1protein found in more fusions100.5289.743Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
131 USP9Xinteractor90.4179.916DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
132 VCPprotein found in more fusions280.208188.834AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
133 VPS16interactor21.0000Vps16_C (PF04840, IPR006925): Vps16, C-terminal region
Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
134 VSIG2interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
135 XPO1interactor410.155520.379CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
136 YEATS4interactor41.0000YEATS (PF03366, IPR005033): YEATS family
SOGA (PF11365, IPR027881): Protein SOGA
137 YWHAQinteractor120.42414.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
138 YWHAZprotein found in more fusions230.28681.64314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
139 ZSCAN26interactor21.0000C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 GDI2P1interactorNA
2 MTORparental proteinDUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat

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