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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins10 (31.25 %)
The number (and %) of the tumor suppressors4 (12.50 %)
Total number of binary PPIs (saturation %)96 (19.35 %)
The number (and %) of affected PPIs31 (32.29 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI4.938
Assortativity coefficient-0.2649
The network average Clustering coefficient0.522
The number (and %) of a zero Clustering coefficients6 (18.75 %)
The number (and %) of a zero Betweenness Centrality12 (37.50 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SYNE1 All fusions
: BE826658;
Proteins found in more fusions GAN (see 1 fusions); PPME1 (see 1 fusions); MCM2 (see 1 fusions); EZH2 (see 1 fusions); APC (see 1 fusions); NDEL1 (see 1 fusions); LMNA (see 3 fusions); SUZ12 (see 2 fusions); TRIM29 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE826658chimera310.103723.633Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
IncA (PF04156, IPR007285): IncA protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
KASH (PF10541, IPR012315): Nuclear envelope localisation domain
DUF3416 (PF11896, IPR021828): Domain of unknown function (DUF3416)
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
2 APCsuppressor31.0000APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
3 BMI1oncoprotein50.5003.000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
4 CDC42oncoprotein40.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
5 CDC5Linteractor90.42913.500OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
6 CEP63interactor50.6003.667DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
7 DISC1interactor60.5336.667HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
8 DTNBP1interactor100Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
9 EMDinteractor90.50010.333LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
10 EZH2suppressor40.6671.000CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
11 GANprotein found in more fusions200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
12 IFI16suppressor60.4008.000HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
13 IFT57interactor100IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
14 KIAA0368interactor21.0000HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
15 LMNAprotein found in more fusions80.6674.233Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
16 MCM2oncoprotein70.6674.333AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
17 MUSKinteractor100CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Fz (PF01392, IPR020067, SM00063): Fz domain
Ig_3 (PF13927): Immunoglobulin domain
18 NDEL1protein found in more fusions50.6672.000HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
19 NLNinteractor100Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
20 NTRK1oncoprotein100.38918.133I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
21 NUP107interactor80.39313.500Nup84_Nup100 (PF04121, IPR007252): Nuclear pore protein 84 / 107
22 NUP35interactor50.7001.900Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
23 OBSL1interactor90.5009.800BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
24 PPME1protein found in more fusions41.0000Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
25 RNF2interactor60.5004.067zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
26 SH3BP5interactor31.0000SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5)
27 SUN1interactor30.6670.500DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
Mnd1 (PF03962, IPR005647): Mnd1 family
MRP (PF09387, IPR018539): Mitochondrial RNA binding protein MRP
Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
28 SUN2interactor30.6670.667Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
MRP (PF09387, IPR018539): Mitochondrial RNA binding protein MRP
Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
RsbRD_N (PF14361, IPR025751): RsbT co-antagonist protein rsbRD N-terminal domain
CLZ (PF16526, IPR032406): C-terminal leucine zipper domain of cyclic nucleotide-gated channels
29 SUZ12suppressor60.5004.067DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
30 TERF2interactor31.0000Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
31 TNIKinteractor31.0000CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
CNDH2_M (PF16869): PF16858
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
32 TRIM29protein found in more fusions200MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 SYNE1parental proteinBaculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
POX (PF07526, IPR006563, SM00574): Associated with HOX
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
RsbU_N (PF08673, IPR014787): Phosphoserine phosphatase RsbU, N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
THOC7 (PF05615, IPR008501): Tho complex subunit 7
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
KASH (PF10541, IPR012315): Nuclear envelope localisation domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
DUF3416 (PF11896, IPR021828): Domain of unknown function (DUF3416)
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2

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