Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BE767238 is the fusion of parental proteins MXI1, HIF1A (from a repository: Sun Mar 5 14:17:54 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins4 (50.00 %)
The number (and %) of the tumor suppressors2 (25.00 %)
Total number of binary PPIs (saturation %)17 (60.71 %)
The number (and %) of affected PPIs7 (41.18 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI3.000
Assortativity coefficient-0.5290
The network average Clustering coefficient0.571
The number (and %) of a zero Clustering coefficients2 (25.00 %)
The number (and %) of a zero Betweenness Centrality5 (62.50 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MXI1,HIF1A All fusions
: BE767238;
Proteins found in more fusions APP (see 4 fusions); CREBBP (see 6 fusions); EP300 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE767238chimera70.23828.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
2 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 CDC20oncoprotein50.6672.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4 CREBBPsuppressor41.0000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
5 EP300oncoprotein50.6672.000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
6 MAXsuppressor31.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
7 NOTCH2NLinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
8 SIN3Binteractor100Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 APEX1interactorExo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
2 ARNToncoproteinHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
3 ARNT2interactorHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
4 ARNTLsuppressorHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
5 ATMsuppressorFAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
6 BANPsuppressorDUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
7 BCL2oncoproteinBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
8 BCRsuppressorBcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
IQ_SEC7_PH (PF16453, IPR001849): PH domain
9 BHLHE41suppressorAdeno_PIX (PF03955, IPR005641): Adenovirus hexon-associated protein (IX)
Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
10 BRCA1suppressorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
11 BUB1BoncoproteinMad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
12 C19orf70interactorQIL1 (PF15884, IPR026769): Protein QIL1
13 CALCOCO2interactorbZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
14 CAPN1interactorCalpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
15 CDC34oncoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
16 CDK8interactorPkinase (PF00069, IPR000719): Protein kinase domain
17 CDKN2AsuppressorAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
18 CEP350interactorCAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
Complex1_LYR_2 (PF13233): Complex1_LYR-like
AAA_23 (PF13476): AAA domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
19 COMMD1interactorCOMMD1_N (PF17221): COMMD1 N-terminal domain
COMM_domain (PF07258): COMM domain
20 COPS5interactorJAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
21 CTNNB1oncoproteinArm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
22 CUL2suppressorCullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
23 DAP3interactorDAP3 (PF10236, IPR019368): Mitochondrial ribosomal death-associated protein 3
24 DCUN1D1interactorCullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
25 DNAJB1suppressorDnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
26 EAF2suppressorPaf1 (PF03985, IPR007133): Paf1
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
27 EGLN1suppressorzf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
28 EGLN2interactor2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
29 EGLN3suppressor2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
30 ENTPD5interactorGDA1_CD39 (PF01150, IPR000407): GDA1/CD39 (nucleoside phosphatase) family
31 EPAS1suppressorCorona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
32 ESR1suppressorOest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
33 F12interactorEGF (PF00008, IPR000742, SM00181): EGF-like domain
fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Kringle (PF00051, IPR000001): Kringle domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
34 FAF1interactorUBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
35 FAF2interactorDUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
36 FBXW11interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
37 FBXW7suppressorMem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
38 FDX1interactorFer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
39 FHL2oncoproteinLIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
40 FN1oncoproteinfn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
41 GKAP1interactorCENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
42 GPLD1interactorFG-GAP (PF01839, IPR013517): FG-GAP repeat
Zn_dep_PLPC (PF00882, IPR029002, SM00770): Zinc dependent phospholipase C
43 HDAC1suppressorFSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
44 HDAC2suppressorHist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
45 HDAC3suppressorHist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
46 HDAC4oncoproteinBorrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
47 HDAC5interactorHist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
48 HDAC6oncoproteinHist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
49 HDAC7interactorHist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
50 HEXIM1oncoproteinAPG6 (PF04111, IPR007243): Autophagy protein Apg6
DivIC (PF04977, IPR007060): Septum formation initiator
Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region
HEXIM (PF15313, IPR024872): Hexamethylene bis-acetamide-inducible protein
51 HIF1Aparental proteinDicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
52 HIF1ANinteractorCupin_8 (PF13621): Cupin-like domain
53 HSP90AA1oncoproteinHATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
54 HSP90AB1oncoproteinHATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
55 HSPA4interactorHerpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
56 HSPA8oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
57 ING1suppressorPHD (PF00628, IPR019787, SM00249): PHD-finger
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
58 JUNoncoproteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
59 KAT2BinteractorAcetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
60 KDM3AsuppressorC1_2 (PF03107, IPR004146): C1 domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
61 KRT40interactorFilament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
62 KRTAP10-3interactorKeratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
63 KRTAP10-5interactorKeratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
64 KRTAP10-7interactorKeratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
65 KRTAP10-8interactorKeratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
66 KRTAP10-9interactorKeratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
67 LAMP2interactorLamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
68 LYSMD2interactorLysM (PF01476, IPR018392, SM00257): LysM domain
HCV_NS5a_C (PF12941, IPR024350): HCV NS5a protein C-terminal region
69 MAFGoncoproteinbZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
ThrE_2 (PF12821, IPR024528): Threonine/Serine exporter, ThrE
70 MAFKoncoproteinbZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
71 MAPK1oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
72 MCM3interactorMCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
73 MCM7interactorMCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
74 MDM2oncoproteinPinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
75 MED12oncoproteinMed12 (PF09497, IPR019035): Transcription mediator complex subunit Med12
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877)
Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain
Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
76 MED13oncoproteinMed13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
77 MED13LinteractorTotivirus_coat (PF05518, IPR008871): Totivirus coat protein
Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
78 MED14interactorMed14 (PF08638, IPR013947): Mediator complex subunit MED14
79 MED15interactorMed15 (PF09606, IPR019087): ARC105 or Med15 subunit of Mediator complex non-fungal
80 MED23interactorMed23 (PF11573, IPR021629): Mediator complex subunit 23
81 MID2interactorfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
82 MTA1oncoproteinBAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
83 MXI1parental proteinEMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
84 MYConcoproteinHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
85 NAA10oncoproteinAcetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
86 NBEAL1interactorBeach (PF02138, IPR000409, SM01026): Beige/BEACH domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)
87 NCOA1oncoproteinDUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
88 NDNsuppressorMAGE (PF01454, IPR002190): MAGE family
89 NESinteractorAnthrax-tox_M (PF09156, IPR015239): Anthrax toxin lethal factor, middle domain
Filament (PF00038, IPR001664): Intermediate filament protein
HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Prominin (PF05478, IPR008795): Prominin
90 NLNinteractorPeptidase_M3 (PF01432, IPR001567): Peptidase family M3
91 NR4A1suppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
92 NSFL1CinteractorSEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
93 OS9interactorDNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
94 OTUD7BinteractorOTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
UBA_4 (PF14555): UBA-like domain
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
95 PARP1suppressorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
96 PCGF2suppressorzf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
97 PIAS1suppressorHerpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
98 PKMoncoproteinPK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
99 PLD1suppressorPH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
100 PLD2interactorPH (PF00169, IPR001849, SM00233): PH domain
PLDc (PF00614, IPR001736, SM00155): Phospholipase D Active site motif
PX (PF00787, IPR001683, SM00312): PX domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
101 PLEKHA5interactorPH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
102 PSMA7interactorProteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
103 PSMC3interactorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
104 PSMD10interactorAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
105 PTGES3interactorCS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
106 RACK1suppressorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
107 RAD23BsuppressorK_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
108 RB1suppressorRB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
109 RBX1oncoproteinzf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
110 RELAoncoproteinDEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
111 RHOBTB3interactorBTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
112 RPL23AP32interactorNA
113 RPTORinteractorHEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
114 RUNX2suppressorDUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Runt (PF00853, IPR013524): Runt domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
115 RUVBL2oncoproteinTIP49 (PF06068, IPR010339): TIP49 C-terminus
116 RWDD3interactorDUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115)
RWD (PF05773, IPR006575, SM00591): RWD domain
117 SART3interactorCENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
Lsm_interact (PF05391, IPR008669): Lsm interaction motif
Phage_GPD (PF05954): Phage late control gene D protein (GPD)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_14 (PF13428): Tetratricopeptide repeat
MRI (PF15325, IPR028278): Modulator of retrovirus infection
LSM_int_assoc (PF16605): LSM-interacting associated unstructured
118 SAT1interactorAcetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
119 SAT2interactorAcetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
120 SENP3interactorNop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
121 SEPT9oncoproteinSeptin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
122 SHC1oncoproteinPID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
123 SIN3AoncoproteinSin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
124 SMAD3oncoproteinMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
125 SMARCA2suppressorDUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
126 SMARCA4suppressorDUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
127 SMC3oncoproteinSMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
128 SP1interactorzf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
129 SQSTM1oncoproteinPB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
130 SRConcoproteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
131 SSX4oncoproteinKRAB (PF01352, IPR001909, SM00349): KRAB box
SSXRD (PF09514, IPR019041): SSXRD motif
132 STAT3suppressorSH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
133 STUB1suppressorU-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
134 TCEANC2interactorMed26 (PF08711, IPR017923): TFIIS helical bundle-like domain
135 TCEB1oncoproteinSkp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
136 TCEB2interactorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
137 TP53suppressorDEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
138 TRAF6interactorSlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
139 TRIM28interactorASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
140 TTC1interactorTPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
141 UACAinteractorAPG6 (PF04111, IPR007243): Autophagy protein Apg6
DivIC (PF04977, IPR007060): Septum formation initiator
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
MAD (PF05557, IPR008672): Mitotic checkpoint protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
SHE3 (PF17078, IPR031398): SWI5-dependent HO expression protein 3
142 UBE2D1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
143 UBE2IinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
144 UBXN1interactorSelenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
145 UBXN7interactorUBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
146 USP19interactorCS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
147 USP20interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
148 UTP23interactorFcf1 (PF04900, IPR006984): Fcf1
149 VCPinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
150 VHLsuppressorTrypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
151 VHLLsuppressorVHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
152 WWOXsuppressoradh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
153 WWTR1interactorWW (PF00397, IPR001202, SM00456): WW domain
154 ZC3H12AinteractorRNase_Zc3h12a (PF11977, IPR021869): Zc3h12a-like Ribonuclease NYN domain
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
155 ZNF197interactorKRAB (PF01352, IPR001909, SM00349): KRAB box
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
156 ZNF518AinteractorCBP4 (PF07960, IPR012420): CBP4
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Fer4_9 (PF13187, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain

B a c k    t o    T o p ⇑