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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BE767210 is the fusion of parental proteins TGFB2, CDH2 (from a repository: Tue May 9 01:19:15 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins7 (28.00 %)
The number (and %) of the tumor suppressors11 (44.00 %)
Total number of binary PPIs (saturation %)50 (16.67 %)
The number (and %) of affected PPIs24 (48.00 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.680
Assortativity coefficient-0.4133
The network average Clustering coefficient0.576
The number (and %) of a zero Clustering coefficients7 (28.00 %)
The number (and %) of a zero Betweenness Centrality17 (68.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: TGFB2,CDH2 All fusions
: BE767210;
Proteins found in more fusions APP (see 4 fusions); CREBBP (see 6 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE767210chimera240.080449.333Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
2 APPprotein found in more fusions70.4677.667APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 BMP2suppressor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
4 CDH11suppressor21.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
5 CDH4suppressor100Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
6 CDONoncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Glyco_hydro_76 (PF03663, IPR005198): Glycosyl hydrolase family 76
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Fer4_2 (PF12797, IPR001450): 4Fe-4S binding domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
7 CEBPAsuppressor31.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
8 CREBBPsuppressor31.0000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
9 CTNNB1oncoprotein100.28931.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
10 CTNND1suppressor40.8330.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
11 DBN1oncoprotein40.8330.667Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
12 DCNsuppressor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 DDR2suppressor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
14 FBXO45interactor21.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
F-box-like (PF12937, IPR001810): F-box-like
15 JUPsuppressor40.8330.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
16 KTN1oncoprotein21.0000ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
17 LRRC7interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
18 MRPL58interactor21.0000RF-1 (PF00472, IPR000352): RF-1 domain
19 NTRK1oncoprotein90.39316.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 PRPHinteractor100Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
21 PZPinteractor100A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
DUF3974 (PF13120, IPR025005): Domain of unknown function (DUF3974)
SQHop_cyclase_N (PF13249, IPR032697): Squalene-hopene cyclase N-terminal domain
DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
22 SPTBN1suppressor40.6672.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
23 TGFBR2suppressor31.0000ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
24 VASNinteractor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TraW_N (PF12477, IPR025864): Sex factor F TraW protein N terminal
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
25 VTNinteractor21.0000Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACTA1interactorActin (PF00022, IPR004000, SM00268): Actin
2 BOConcoproteinfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
ISET-FN3_linker (PF16625): Unstructured linking region I-set and fnIII on Brother of CDO
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
3 CCNA2oncoproteinCyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
4 CDH2parental proteinCadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
Cadherin_3 (PF16184): Cadherin-like
5 CTNNA1oncoproteinVinculin (PF01044, IPR006077): Vinculin family
6 DDR1oncoproteinLamprin (PF06403, IPR009437): Lamprin
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
7 EXOC5interactorSec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
8 GAAinteractorGlyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
NtCtMGAM_N (PF16863, IPR031727): N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
DUF5110 (PF17137): Domain of unknown function (DUF5110)
9 GNA12oncoproteinG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
10 GNA13interactorG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
11 IARS2interactorAnticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
12 MRPL23interactorRibosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
13 MRPL49interactorImg2 (PF05046, IPR007740): Mitochondrial large subunit ribosomal protein (Img2)
14 MTHFD1interactorFTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
15 NACA2interactorNAC (PF01849, IPR002715): NAC domain
16 NENFinteractorCyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
17 PCinteractorBiotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
18 PDIA4interactorCalsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
19 PKP4interactorArm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
20 PPT2interactorAbhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
21 PRKCDBPsuppressorA1_Propeptide (PF07966, IPR012848): A1 Propeptide
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
22 PTBP3interactorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
23 RAB8BoncoproteinRas (PF00071, IPR001806, SM00173): Ras family
24 RPL14interactorKOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
25 RPL21interactorRibosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
26 RPL3interactorRibosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
27 RPL32interactorRibosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
28 RPL8interactorRibosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
29 RPS16interactorRibosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
30 RPS26interactorRibosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
31 RYKoncoproteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
32 SARS2interactortRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
DUF2312 (PF10073, IPR018753): Uncharacterized protein conserved in bacteria (DUF2312)
DUF4445 (PF14574, IPR027980): Domain of unknown function (DUF4445)
33 SKP1oncoproteinSkp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
34 SSR4interactorTRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
35 SUPT5HinteractorKOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
36 TGFB2parental proteinTGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
37 TMEM256interactorDUF423 (PF04241, IPR006696): Protein of unknown function (DUF423)
DUF2648 (PF10855, IPR022561): Protein of unknown function (DUF2648)
38 TPM4oncoproteinTropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
39 UBCinteractorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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