Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BE694274 is the fusion of parental proteins FANCL (from a repository: Sat Nov 12 16:40:38 2016)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins9 (30.00 %)
The number (and %) of the tumor suppressors4 (13.33 %)
Total number of binary PPIs (saturation %)105 (24.14 %)
The number (and %) of affected PPIs29 (27.62 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI6.267
Assortativity coefficient-0.3610
The network average Clustering coefficient0.559
The number (and %) of a zero Clustering coefficients8 (26.67 %)
The number (and %) of a zero Betweenness Centrality12 (40.00 %)


List of the fusions

PPI for parental proteins: FANCL All fusions
: BE694274;
Proteins found in more fusions FANCA (see 1 fusions); FANCG (see 1 fusions); PCNA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BE694274chimera290.160607.579WD-3 (PF09765, IPR019162): WD-repeat region
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
2 CCDC36interactor100DUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
3 CENPSsuppressor110.8911.579CENP-S (PF15630, IPR029003): CENP-S protein
COMMD1_N (PF17221): COMMD1 N-terminal domain
4 CENPXinteractor90.9440.500CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
5 CHCHD3interactor30.6671.000DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G
6 DOCK8interactor200DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
7 EIF4ENIF1interactor21.0000EIF4E-T (PF10477, IPR018862): Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
8 FAAP100interactor110.8911.579FANCAA (PF15146, IPR029251): Fanconi anemia-associated
9 FAAP20interactor110.7649.405UBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger
FANCA_interact (PF15751, IPR031491): FAAP20 FANCA interaction domain
10 FAAP24interactor90.9440.508Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_2 (PF12826): Helix-hairpin-helix motif
11 FANCAoncoprotein140.69215.246Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
12 FANCBinteractor81.0000DP (PF08781, IPR014889, SM01138): Transcription factor DP
13 FANCConcoprotein110.7457.222Fanconi_C (PF02106, IPR000686): Fanconi anaemia group C protein
14 FANCD2oncoprotein60.4007.667FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
15 FANCFoncoprotein100.8672.222FANCF (PF11107): Fanconi anemia group F protein (FANCF)
16 FANCGsuppressor140.70511.913BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
17 FANCIinteractor30.6670.500DUF3972 (PF13118, IPR025002): Protein of unknown function (DUF3972)
FANCI_S1-cap (PF14674, IPR029305): FANCI solenoid 1 cap
FANCI_S1 (PF14675, IPR029308): FANCI solenoid 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3
FANCI_S4 (PF14678, IPR029314): FANCI solenoid 4
FANCI_HD1 (PF14679, IPR029310): FANCI helical domain 1
FANCI_HD2 (PF14680, IPR029312): FANCI helical domain 2
18 FANCMinteractor130.75811.579ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MRC1 (PF09444, IPR018564): MRC1-like domain
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
HHH_2 (PF12826): Helix-hairpin-helix motif
FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
19 GRNoncoprotein100Granulin (PF00396, IPR000118, SM00277): Granulin
Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
20 HES1oncoprotein51.0000Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
21 IKZF3suppressor200C1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
22 KIFC3oncoprotein40.6671.000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
23 LZTS2suppressor30.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
24 PCNAoncoprotein40.6670.500PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
25 RBM45interactor200RNA_bind (PF08675, IPR014789): RNA binding domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 RIMBP3interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
G-gamma (PF00631, IPR015898, SM00224): GGL domain
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
27 SSX2IPinteractor40.6671.000ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
28 TFCP2interactor100CP2 (PF04516, IPR007604): CP2 transcription factor
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
29 UBE2Tinteractor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
30 UBE2Winteractor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

B a c k    t o    T o p ⇑

List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 FANCLparental proteinWD-3 (PF09765, IPR019162): WD-repeat region
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain

B a c k    t o    T o p ⇑