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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: BE615097 is the fusion of parental proteins SMG1, CHP1 (from a repository: Tue Oct 22 18:00:26 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins10 (27.78 %)
The number (and %) of the tumor suppressors1 (2.78 %)
Total number of binary PPIs (saturation %)160 (25.40 %)
The number (and %) of affected PPIs35 (21.88 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI8.278
Assortativity coefficient-0.2900
The network average Clustering coefficient0.673
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality5 (13.89 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CHP1,SMG1 All fusions
: BE615097;
Proteins found in more fusions TUBG1 (see 1 fusions); PABPC1 (see 2 fusions); POLR2E (see 2 fusions); HSP90AA1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE615097chimera350.192562.175Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
SMG1 (PF15785, IPR031559): Serine/threonine-protein kinase smg-1
2 EEF2interactor60.8002.000EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
3 EIF4A3interactor70.9330.222DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
4 ELAVL1oncoprotein110.40020.800RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 GSPT1oncoprotein90.6944.852GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
6 GSPT2interactor50.7003.000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
7 HAUS2interactor40.8330.400DpnII (PF04556, IPR007637): DpnII restriction endonuclease
HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
8 HSP90AA1oncoprotein100.44413.033HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
9 HSP90B1suppressor21.0000CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
10 HSPA4interactor100.33324.867Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
11 HTR6interactor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
12 MAGOHinteractor60.9330.222Mago_nashi (PF02792, IPR004023): Mago nashi protein
13 MOV10interactor30.6670.667AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
14 NCBP2interactor40.8330.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 NXF1interactor130.45522.800NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
16 PABPC1oncoprotein100.6944.852RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
17 POLR2Eprotein found in more fusions80.5716.733RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain
RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
18 PRKCIinteractor40.8330.667PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
19 PRSS23interactor30.6670.667Trypsin (PF00089, IPR001254, SM00020): Trypsin
20 RBM8Ainteractor180.36849.522RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 RUVBL1oncoprotein170.41745.108TIP49 (PF06068, IPR010339): TIP49 C-terminus
22 RUVBL2oncoprotein100.6674.889TIP49 (PF06068, IPR010339): TIP49 C-terminus
23 SHMT2interactor30.6671.000SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
24 SMG7interactor50.7000.786TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
EST1 (PF10374, IPR019458): Telomerase activating protein Est1
EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain
25 SMG8interactor51.0000Smg8_Smg9 (PF10220, IPR019354): Smg8_Smg9
26 SMG9interactor51.0000Smg8_Smg9 (PF10220, IPR019354): Smg8_Smg9
27 TELO2interactor70.6674.133Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein
HEAT_2 (PF13646): HEAT repeats
28 TMEM216interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
29 TTI1interactor90.52810.700Dopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
VHS (PF00790, IPR002014, SM00288): VHS domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
30 TUBA1Aoncoprotein50.6002.000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
31 TUBG1protein found in more fusions70.6003.400Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
32 UPF1interactor190.33974.733UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
33 UPF2interactor80.7622.119DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
34 UPF3Ainteractor70.8570.789Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
35 UPF3Binteractor90.7503.589HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family
TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
DUF2098 (PF09871, IPR019209): Uncharacterized protein conserved in archaea (DUF2098)
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
36 XPO1interactor200.31191.108CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CHP1parental proteinEF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2 SLC9A1interactorDUF1427 (PF07235, IPR009872): Protein of unknown function (DUF1427)
LHC (PF00556, IPR000066): Antenna complex alpha/beta subunit
Na_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
3 SLC9A2oncoproteinNa_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
4 SLC9A3interactorNa_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
5 SLC9A4interactorNa_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
6 SLC9A5interactorNa_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
7 SMG1parental proteinBaculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
SMG1 (PF15785, IPR031559): Serine/threonine-protein kinase smg-1

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