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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BE246630 is the fusion of parental proteins FAM104A, RGPD5 (from a repository: Sat Oct 31 19:04:24 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins7 (33.33 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)35 (16.67 %)
The number (and %) of affected PPIs20 (57.14 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.952
Assortativity coefficient-0.4731
The network average Clustering coefficient0.420
The number (and %) of a zero Clustering coefficients10 (47.62 %)
The number (and %) of a zero Betweenness Centrality16 (76.19 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: RGPD5,FAM104A All fusions
: BE246630;
Proteins found in more fusions MCM2 (see 1 fusions); USP20 (see 1 fusions); RANGAP1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE246630chimera200.058349.667GRIP (PF01465, IPR000237, SM00755): GRIP domain
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
Rab_bind (PF16704, IPR032023): Rab binding domain
2 CCDC151interactor100DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
DUF2721 (PF11026, IPR021279): Protein of unknown function (DUF2721)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
3 CCDC74Binteractor31.0000CCDC92 (PF14916): Coiled-coil domain of unknown function
CCDC74_C (PF14917, IPR029422): Coiled coil protein 74, C terminal
4 CLEC11Ainteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HBS1_N (PF08938, IPR015033): HBS1 N-terminus
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
5 COMTD1interactor100FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
6 FKBP6interactor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
7 MCM2oncoprotein200AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
8 MLF1oncoprotein100Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
9 NR2E1interactor100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
10 PSMD7interactor50.6003.667JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
11 RANoncoprotein40.6672.000Ras (PF00071, IPR001806, SM00173): Ras family
12 RANGAP1protein found in more fusions41.0000RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 RCC1interactor40.6672.000RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
14 SDF4interactor21.0000Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
15 TNPO1interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
16 TSNAXinteractor100Translin (PF01997, IPR002848): Translin family
17 UCHL5oncoprotein50.8330.667Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
18 USP14interactor31.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
19 USP20protein found in more fusions31.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
20 VPS28interactor100VPS28 (PF03997, IPR007143): VPS28 protein
21 ZBTB46interactor100ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
C1_2 (PF03107, IPR004146): C1 domain
Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
DUF4428 (PF14471, IPR027872): Domain of unknown function (DUF4428)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 FAM104Aparental proteinFAM104 (PF15434, IPR029222): Family 104
2 MOV10interactorAAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
3 NSFL1CinteractorSEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
4 NXF1interactorNTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
5 RGPD5parental proteinGRIP (PF01465, IPR000237, SM00755): GRIP domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
FlxA (PF14282, IPR025577): FlxA-like protein
TPR_19 (PF14559): Tetratricopeptide repeat
Rab_bind (PF16704, IPR032023): Rab binding domain
6 UBXN2BinteractorSEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
7 UBXN6interactorPUB (PF09409, IPR018997): PUB domain
UBX (PF00789, IPR001012, SM00166): UBX domain
8 VCPinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

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