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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BE181974 is the fusion of parental proteins AMD1 (from a repository: Thu Dec 8 05:42:45 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins3 (21.43 %)
The number (and %) of the tumor suppressors1 (7.14 %)
Total number of binary PPIs (saturation %)17 (18.68 %)
The number (and %) of affected PPIs13 (76.47 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.5311
The network average Clustering coefficient0.144
The number (and %) of a zero Clustering coefficients11 (78.57 %)
The number (and %) of a zero Betweenness Centrality13 (92.86 %)


List of the fusions

PPI for parental proteins: AMD1 All fusions
: BE181974;
Proteins found in more fusions HSPB1 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 BE181974chimera130.013154.000SAM_decarbox (PF01536, IPR001985): Adenosylmethionine decarboxylase
2 ASTLinteractor100Astacin (PF01400, IPR001506): Astacin (Peptidase family M12A)
3 BMP7interactor200TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
4 CLEC11Ainteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HBS1_N (PF08938, IPR015033): HBS1 N-terminus
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
5 DNASE2Binteractor100DNase_II (PF03265, IPR004947): Deoxyribonuclease II
6 DOK3suppressor100IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
7 ELAVL1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 HSPB1oncoprotein200HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
9 KPTNinteractor100AcetylCoA_hyd_C (PF13336, IPR026888): Acetyl-CoA hydrolase/transferase C-terminal domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
10 MED4interactor21.0000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
11 NYXinteractor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
12 POLR2Minteractor100GCOM2 (PF15328, IPR026213): Putative GRINL1B complex locus protein 2
13 PRELPinteractor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
14 RTBDNinteractor100Folate_rec (PF03024, IPR018143): Folate receptor family
Serglycin (PF04360, IPR007455): Serglycin

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADCYAP1interactorHormone_2 (PF00123, IPR000532, SM00070): Peptide hormone
2 AMD1parental proteinSAM_decarbox (PF01536, IPR001985): Adenosylmethionine decarboxylase
3 BMP15interactorTGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain

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