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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)137
The number (and %) of the onco-proteins40 (29.20 %)
The number (and %) of the tumor suppressors16 (11.68 %)
Total number of binary PPIs (saturation %)702 (7.54 %)
The number (and %) of affected PPIs136 (19.37 %)
The number of possible different fusions30
PPI diameter2
PPI radius1
The average degree of PPI9.518
Assortativity coefficient-0.3044
The network average Clustering coefficient0.504
The number (and %) of a zero Clustering coefficients14 (10.22 %)
The number (and %) of a zero Betweenness Centrality34 (24.82 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PRMT5 All fusions
: BE063240;
Proteins found in more fusions CUL4A (see 4 fusions); VCP (see 4 fusions); HSP90AA1 (see 2 fusions); ZDHHC17 (see 2 fusions); JAK2 (see 3 fusions); CUL7 (see 2 fusions); WDR77 (see 1 fusions); CUL3 (see 1 fusions); LUC7L (see 1 fusions); RBFOX2 (see 2 fusions); TRAF4 (see 1 fusions); TCF3 (see 4 fusions); GAN (see 1 fusions); YWHAZ (see 1 fusions); MYOD1 (see 1 fusions); STUB1 (see 1 fusions); SKI (see 1 fusions); POLR2A (see 2 fusions); JAK1 (see 1 fusions); SHC1 (see 1 fusions); SMARCC1 (see 2 fusions); HDAC5 (see 1 fusions); EZH2 (see 1 fusions); MBD2 (see 1 fusions); CCND1 (see 1 fusions); CSNK1E (see 1 fusions); NCL (see 3 fusions); TP53 (see 3 fusions); CTNNBL1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE063240chimera1360.05613425.845PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
2 AGO3interactor70.5713.320ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
3 AGO4interactor60.6002.753ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
4 AHSA1interactor50.8000.310Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
5 AJUBAoncoprotein21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
6 ALKBH3interactor30.6671.0002OG-FeII_Oxy_2 (PF13532, IPR027450): 2OG-Fe(II) oxygenase superfamily
7 ARGLU1interactor50.8330.133eIF3_subunit (PF08597, IPR013906): Translation initiation factor eIF3 subunit
Kri1 (PF05178, IPR018034): KRI1-like family
ARGLU (PF15346): Arginine and glutamate-rich 1
8 ARID1Boncoprotein51.0000ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Presenilin (PF01080, IPR001108): Presenilin
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
Spt20 (PF12090, IPR021950): Spt20 family
9 ARRB1interactor100.5118.526Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
10 ARRB2interactor140.34131.352Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
11 CALUinteractor40.8330.143EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12 CAPN1interactor90.27816.015Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
13 CCAR2suppressor90.41710.545DREPP (PF05558, IPR008469): DREPP plasma membrane polypeptide
IncA (PF04156, IPR007285): IncA protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DBC1 (PF14443, IPR025954, SM01122): DBC1
S1-like (PF14444, IPR025223): S1-like
14 CCND1oncoprotein60.7001.000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
15 CDK19interactor40.8330.500Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
16 CDYL2interactor100Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
17 CHTOPinteractor50.6003.167API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Lamprin (PF06403, IPR009437): Lamprin
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
18 CLK1interactor50.6672.000PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
19 CLK3interactor90.42912.182Pkinase (PF00069, IPR000719): Protein kinase domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
20 CLNS1Ainteractor200.34270.607Voldacs (PF03517): Regulator of volume decrease after cellular swelling
21 COPRSinteractor40.5001.150COPR5 (PF15340, IPR029289): Cooperator of PRMT5 family
22 COPS4interactor90.6114.670DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
23 COPS7Ainteractor90.5839.841PCI (PF01399, IPR000717, SM00088): PCI domain
24 CRY1interactor70.4675.175DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
25 CSNK1Eprotein found in more fusions60.5002.367APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
26 CTDP1interactor30.6670.286Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
FCP1_C (PF09309, IPR015388): FCP1, C-terminal
NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
27 CTNNBL1protein found in more fusions60.4003.267Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DASH_Dad4 (PF08650, IPR013959): DASH complex subunit Dad4
CTNNBL (PF08216, IPR013180, SM01156): Catenin-beta-like, Arm-motif containing nuclear
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
28 CTPS1interactor70.6671.032CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
29 CUL3protein found in more fusions350.214268.184Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
30 CUL4Aprotein found in more fusions150.42926.623Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
31 CUL7protein found in more fusions230.25591.684ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
32 DCAF8interactor50.9000.222DUF1635 (PF07795, IPR012862): Protein of unknown function (DUF1635)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4661 (PF15576, IPR029073): Domain of unknown function (DUF4661)
33 DNMT3Asuppressor30.6670.500DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
34 DSToncoprotein50.5002.900CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Phasin (PF05597, IPR008769): Poly(hydroxyalcanoate) granule associated protein (phasin)
Spectrin (PF00435, IPR002017): Spectrin repeat
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
XhlA (PF10779, IPR019715): Haemolysin XhlA
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
NYD-SP28 (PF14772): Sperm tail
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
35 DYNC1H1interactor120.39415.118AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1
DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1
AAA_7 (PF12775): P-loop containing dynein motor region D3
MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor
AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4
AAA_9 (PF12781): ATP-binding dynein motor region D5
36 EIF2S1interactor40.5000.447EIF_2_alpha (PF07541, IPR011488): Eukaryotic translation initiation factor 2 alpha subunit
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
37 EIF4A3interactor200.36854.206DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
38 EPB41L3suppressor110.45514.5084_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
39 EZH2suppressor120.32725.245CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
40 FBXO25suppressor40.6671.167Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
41 FBXO6interactor170.27251.939FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
42 FN1oncoprotein230.25388.794fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
43 FOXK1interactor60.6672.633Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
44 GANprotein found in more fusions90.3939.601BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
45 GLIS3interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
46 GTPBP2interactor100GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
47 HDAC5protein found in more fusions150.31935.675Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
48 HECW2interactor50.5001.833C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
49 HIST2H2ACinteractor70.4767.769Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
50 HOXA9oncoprotein31.0000Hox9_act (PF04617, IPR006711): Hox9 activation region
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
51 HOXC4interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
52 HSP90AA1oncoprotein360.175369.662HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
53 ING2suppressor60.7332.233PHD (PF00628, IPR019787, SM00249): PHD-finger
S1FA (PF04689, IPR006779): DNA binding protein S1FA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
54 JAK1oncoprotein100.36112.108FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
55 JAK2oncoprotein60.5003.900FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
56 JAK3oncoprotein60.4007.167Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
57 KHDRBS2interactor41.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
58 LDHAL6Binteractor21.0000Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
59 LENG8interactor21.0000SAC3_GANP (PF03399, IPR005062): SAC3/GANP family
60 LSM11interactor40.6670.472LSM (PF01423, IPR001163): LSM domain
61 LUC7Lprotein found in more fusions100.33318.444LUC7 (PF03194, IPR004882): LUC7 N_terminus
Hid1 (PF12722): High-temperature-induced dauer-formation protein
62 MAGEB2interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
63 MBD2oncoprotein50.5001.019API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
MBD_C (PF14048, IPR025884): C-terminal domain of methyl-CpG binding protein 2 and 3
MBDa (PF16564, IPR032343): p55-binding region of Methyl-CpG-binding domain proteins MBD
64 MBPinteractor100Myelin_MBP (PF01669, IPR000548): Myelin basic protein
65 MCM5oncoprotein110.47312.261MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
66 MCRS1interactor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
67 MEF2Doncoprotein21.0000DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
68 MYEF2interactor70.5244.783RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
69 MYOD1oncoprotein60.4004.352Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Mfp-3 (PF04202, IPR007328): Foot protein 3
Myf5 (PF12232, IPR022032): Myogenic determination factor 5
70 MYOGinteractor30.6670.667Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
71 MYSM1interactor30.6671.000SWIRM (PF04433, IPR007526): SWIRM domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
72 NCBP1interactor100.46713.669MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
73 NCLprotein found in more fusions260.230130.169DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
74 NELFCDoncoprotein50.6001.467TH1 (PF04858, IPR006942): TH1 protein
75 NSFL1Cinteractor31.0000SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
76 NTRK1oncoprotein430.125533.810I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
77 NUDCD2interactor41.0000CS (PF04969, IPR007052): CS domain
DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
78 OLA1interactor60.5332.187Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
79 PAN2interactor120.50013.141RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
80 PAXIP1interactor40.6670.786BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
81 PDCD4suppressor50.7000.667Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
MA3 (PF02847, IPR003891, SM00544): MA3 domain
82 PDIA6interactor100.4228.735FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
83 PHYHIPinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
84 PIK3C3interactor31.0000PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
85 POLR2Aprotein found in more fusions150.26443.236RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
86 PRDM1suppressor31.0000SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
87 PRPF38Ainteractor31.0000PRP38 (PF03371, IPR005037): PRP38 family
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
88 RANBP2oncoprotein61.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693)
IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain
Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
89 RBFOX2protein found in more fusions90.4649.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
90 RBM23interactor40.6671.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
RSRP (PF17069): Arginine/Serine-Rich protein 1
91 RELAoncoprotein130.31829.289DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
92 RRP12interactor60.7330.615NUC173 (PF08161, IPR012978): NUC173 domain
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
PPP4R2 (PF09184, IPR015267): PPP4R2
Ribosomal_L37 (PF08561, IPR013870): Mitochondrial ribosomal protein L37
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
93 RSRP1oncoprotein21.0000RSRP (PF17069): Arginine/Serine-Rich protein 1
94 SBNO1oncoprotein21.0000Helicase_C_4 (PF13871, IPR026937): C-terminal domain on Strawberry notch homologue
AAA_34 (PF13872): P-loop containing NTP hydrolase pore-1
95 SF3A3interactor130.38531.802DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449)
SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
96 SHC1oncoprotein50.8330.667PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
97 SIN3Aoncoprotein140.37436.452Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
98 SIRT6suppressor50.5003.000SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
99 SIRT7interactor230.249115.182DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
100 SKIoncoprotein60.6001.482c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
101 SLU7interactor100Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Slu7 (PF11708, IPR021715): Pre-mRNA splicing Prp18-interacting factor
zf-CCHC_4 (PF14392, IPR025836): Zinc knuckle
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
102 SMARCA2suppressor90.6117.433DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
103 SMARCA4suppressor180.34068.371DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
104 SMARCC1suppressor140.51318.292SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
105 SMARCE1interactor80.7143.208DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
106 SMN1interactor170.30853.933SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
107 SMURF1interactor170.28350.575C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
108 SNRNP70interactor210.31073.410RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
109 SNRPBinteractor160.50822.248LSM (PF01423, IPR001163): LSM domain
110 SNRPD1interactor210.39059.500API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
LSM (PF01423, IPR001163): LSM domain
111 SNRPD3interactor230.37574.997LSM (PF01423, IPR001163): LSM domain
112 SPAG8interactor100Zip (PF02535, IPR003689): ZIP Zinc transporter
113 SREBF1interactor31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
114 SSTR1interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
115 STUB1suppressor140.33338.752U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
116 SUPT5Hinteractor110.47315.272KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
117 TCF3suppressor50.5002.667CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
118 TERF1interactor90.5717.400TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
119 TERF2interactor100.4729.337Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
120 TINAGL1interactor21.0000Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII)
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
Propeptide_C1 (PF08127, IPR012599): Peptidase family C1 propeptide
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
121 TLE4interactor21.0000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4662 (PF15578, IPR028970): Domain of unknown function (DUF4662)
122 TP53suppressor340.189304.500DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
123 TRAF4oncoprotein40.6670.250MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
124 TRIM21interactor90.3939.167DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
125 UBE2Q2interactor31.0000Josephin (PF02099, IPR006155): Josephin
RWD (PF05773, IPR006575, SM00591): RWD domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
DUF2890 (PF11081, IPR021304): Protein of unknown function (DUF2890)
126 UBL4Ainteractor120.31819.945ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
127 VASPinteractor70.4674.128ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
128 VCAM1interactor130.26921.913C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
129 VCPprotein found in more fusions310.195234.893AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
130 WDR77oncoprotein370.170409.917LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
131 WWOXsuppressor120.43916.483adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
132 YWHAZprotein found in more fusions190.24867.91614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
133 ZDHHC17protein found in more fusions50.5002.500zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
134 ZNF2interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
135 ZNF224interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
136 ZNF436interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
137 ZUFSPinteractor100zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Peptidase_C78 (PF07910, IPR012462): Peptidase family C78
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CDK4oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
2 CDK8interactorPkinase (PF00069, IPR000719): Protein kinase domain
3 DIO3interactorT4_deiodinase (PF00837, IPR000643): Iodothyronine deiodinase
4 FAM76BinteractorFAM76 (PF16046, IPR032017): FAM76 protein
5 FBLinteractorFibrillarin (PF01269, IPR000692): Fibrillarin
6 GAR1interactorGar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
7 GRHL3interactorCP2 (PF04516, IPR007604): CP2 transcription factor
8 H3F3ConcoproteinHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
9 HDGFinteractorPWWP (PF00855, IPR000313, SM00293): PWWP domain
10 HIST1H3AinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
11 HIST1H3EinteractorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12 HIST1H4AinteractorCENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
13 HIST3H3interactorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14 HIST4H4interactorCENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
15 ID2oncoproteinHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
16 ING5suppressorING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
17 MAGOHinteractorMago_nashi (PF02792, IPR004023): Mago nashi protein
18 NFE4interactorNA
19 POLR2CinteractorRNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
20 PRMT5parental proteinPRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
21 RIOK1interactorRIO1 (PF01163, IPR018934): RIO1 family
22 SMARCB1suppressorSNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
23 TRIB3interactorPkinase (PF00069, IPR000719): Protein kinase domain
24 TYK2interactorPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
25 WDR5interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat

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