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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BE001767 is the fusion of parental proteins EFNA5, FGD4 (from a repository: Tue Feb 28 23:48:10 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)5
The number (and %) of the onco-proteins4 (80.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)7 (70.00 %)
The number (and %) of affected PPIs4 (57.14 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI1.600
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients5 (100.00 %)
The number (and %) of a zero Betweenness Centrality4 (80.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: EFNA5,FGD4 All fusions
: BE001767;
Proteins found in more fusions MYC (see 1 fusions); GRIP1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BE001767chimera4012.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
2 CAPZA2interactor100F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
3 GRIP1protein found in more fusions200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
4 MYConcoprotein200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
5 SRConcoprotein200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 EFNA5parental proteinEphrin (PF00812, IPR001799): Ephrin
2 EPHA3suppressorEGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
3 EPHA7oncoproteinEGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
4 EPHB1interactorEGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
5 FGD4parental proteinFYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain

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